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Entry version 170 (16 Oct 2019)
Sequence version 3 (12 Apr 2005)
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Protein

Protein sel-1 homolog 1

Gene

SEL1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNotch signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-901032 ER Quality Control Compartment (ERQC)

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.16.1.4 the endoplasmic reticular retrotranslocon (er-rt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein sel-1 homolog 1
Alternative name(s):
Suppressor of lin-12-like protein 1
Short name:
Sel-1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEL1L
Synonyms:TSA305
ORF Names:UNQ128/PRO1063
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10717 SEL1L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602329 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBV2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 738LumenalSequence analysisAdd BLAST717
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei739 – 759HelicalSequence analysisAdd BLAST21
Topological domaini760 – 794CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6400

Open Targets

More...
OpenTargetsi
ENSG00000071537

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35639

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UBV2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEL1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62512184

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002229422 – 794Protein sel-1 homolog 1Add BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei63PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi127 ↔ 153PROSITE-ProRule annotation
Disulfide bondi141 ↔ 168PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi431N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi608N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UBV2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UBV2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UBV2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBV2

PeptideAtlas

More...
PeptideAtlasi
Q9UBV2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBV2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84077 [Q9UBV2-1]
84078 [Q9UBV2-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1669

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBV2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBV2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9UBV2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000071537 Expressed in 241 organ(s), highest expression level in duodenum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UBV2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UBV2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024267

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and homooligomer (By similarity).

Interacts with SYVN1; the interaction is direct (PubMed:26471130).

Part of a complex containing SEL1L, SYVN1 and DERL2 (PubMed:16186509). May form a complex with ERLEC1, HSPA5, OS9, and SYVN1 (PubMed:18502753, PubMed:18264092).

Interacts with FOXRED2 and EDEM1 (PubMed:19524542, PubMed:19706418).

Interacts with LPL (PubMed:25066055).

Interacts with LMF1; may stabilize the complex formed by LPL and LMF1 and thereby promote the export of LPL dimers (By similarity).

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112300, 71 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UBV2

Database of interacting proteins

More...
DIPi
DIP-46259N

Protein interaction database and analysis system

More...
IntActi
Q9UBV2, 29 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337053

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UBV2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini122 – 170Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST49
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati183 – 218Sel1-like 1Add BLAST36
Repeati219 – 254Sel1-like 2Add BLAST36
Repeati255 – 290Sel1-like 3Add BLAST36
Repeati291 – 326Sel1-like 4Add BLAST36
Repeati373 – 409Sel1-like 5Add BLAST37
Repeati410 – 446Sel1-like 6Add BLAST37
Repeati447 – 482Sel1-like 7Add BLAST36
Repeati483 – 518Sel1-like 8Add BLAST36
Repeati519 – 554Sel1-like 9Add BLAST36
Repeati627 – 662Sel1-like 10Add BLAST36
Repeati664 – 699Sel1-like 11Add BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 737Interaction with ERLEC1, OS9 and SYVN1Add BLAST716
Regioni352 – 537Important for homodimerization and oligomerizationBy similarityAdd BLAST186
Regioni643 – 723Interaction with SYVN1By similarityAdd BLAST81
Regioni738 – 794Mediates retention in the endoplasmic reticulumAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi770 – 793Pro-richAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sel-1 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1550 Eukaryota
COG0790 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156671

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000239927

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UBV2

KEGG Orthology (KO)

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KOi
K14026

Identification of Orthologs from Complete Genome Data

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OMAi
LAQMAMG

Database of Orthologous Groups

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OrthoDBi
357553at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UBV2

TreeFam database of animal gene trees

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TreeFami
TF315257

Family and domain databases

Conserved Domains Database

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CDDi
cd00062 FN2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.10, 3 hits
2.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR006597 Sel1-like
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040 fn2, 1 hit
PF08238 Sel1, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00059 FN2, 1 hit
SM00671 SEL1, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57440 SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVRIGLTLL LCAVLLSLAS ASSDEEGSQD ESLDSKTTLT SDESVKDHTT
60 70 80 90 100
AGRVVAGQIF LDSEESELES SIQEEEDSLK SQEGESVTED ISFLESPNPE
110 120 130 140 150
NKDYEEPKKV RKPALTAIEG TAHGEPCHFP FLFLDKEYDE CTSDGREDGR
160 170 180 190 200
LWCATTYDYK ADEKWGFCET EEEAAKRRQM QEAEMMYQTG MKILNGSNKK
210 220 230 240 250
SQKREAYRYL QKAASMNHTK ALERVSYALL FGDYLPQNIQ AAREMFEKLT
260 270 280 290 300
EEGSPKGQTA LGFLYASGLG VNSSQAKALV YYTFGALGGN LIAHMVLGYR
310 320 330 340 350
YWAGIGVLQS CESALTHYRL VANHVASDIS LTGGSVVQRI RLPDEVENPG
360 370 380 390 400
MNSGMLEEDL IQYYQFLAEK GDVQAQVGLG QLHLHGGRGV EQNHQRAFDY
410 420 430 440 450
FNLAANAGNS HAMAFLGKMY SEGSDIVPQS NETALHYFKK AADMGNPVGQ
460 470 480 490 500
SGLGMAYLYG RGVQVNYDLA LKYFQKAAEQ GWVDGQLQLG SMYYNGIGVK
510 520 530 540 550
RDYKQALKYF NLASQGGHIL AFYNLAQMHA SGTGVMRSCH TAVELFKNVC
560 570 580 590 600
ERGRWSERLM TAYNSYKDGD YNAAVIQYLL LAEQGYEVAQ SNAAFILDQR
610 620 630 640 650
EASIVGENET YPRALLHWNR AASQGYTVAR IKLGDYHFYG FGTDVDYETA
660 670 680 690 700
FIHYRLASEQ QHSAQAMFNL GYMHEKGLGI KQDIHLAKRF YDMAAEASPD
710 720 730 740 750
AQVPVFLALC KLGVVYFLQY IRETNIRDMF TQLDMDQLLG PEWDLYLMTI
760 770 780 790
IALLLGTVIA YRQRQHQDMP APRPPGPRPA PPQQEGPPEQ QPPQ
Length:794
Mass (Da):88,755
Last modified:April 12, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i323EB03DC7485459
GO
Isoform 2 (identifier: Q9UBV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     298-301: GYRY → VSRL
     302-794: Missing.

Note: No experimental confirmation available.
Show »
Length:301
Mass (Da):33,530
Checksum:i951E80519492827F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3B3G3V3B3_HUMAN
Protein sel-1 homolog 1
SEL1L
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti186M → V in AAF29413 (PubMed:10746565).Curated1
Sequence conflicti186M → V in AAL40905 (PubMed:10746565).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029303162D → G. Corresponds to variant dbSNP:rs11499034Ensembl.1
Natural variantiVAR_053963714V → I. Corresponds to variant dbSNP:rs1051193Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013322298 – 301GYRY → VSRL in isoform 2. 1 Publication4
Alternative sequenceiVSP_013323302 – 794Missing in isoform 2. 1 PublicationAdd BLAST493

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB024763 Genomic DNA Translation: BAA89204.1
AB020335 mRNA Translation: BAA87904.1
AF052059 mRNA Translation: AAF29413.1
AF157516 Genomic DNA Translation: AAF24176.1
AF198647
, AF198631, AF198632, AF198633, AF198634, AF198635, AF198636, AF198637, AF198638, AF198639, AF198640, AF198641, AF198642, AF198643, AF198644, AF198645, AF198646 Genomic DNA Translation: AAL40905.1
AY358651 mRNA Translation: AAQ89014.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS58333.1 [Q9UBV2-2]
CCDS9876.1 [Q9UBV2-1]

NCBI Reference Sequences

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RefSeqi
NP_001231913.1, NM_001244984.1 [Q9UBV2-2]
NP_005056.3, NM_005065.5 [Q9UBV2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000336735; ENSP00000337053; ENSG00000071537 [Q9UBV2-1]
ENST00000555824; ENSP00000450709; ENSG00000071537 [Q9UBV2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6400

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6400

UCSC genome browser

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UCSCi
uc001xvo.5 human [Q9UBV2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024763 Genomic DNA Translation: BAA89204.1
AB020335 mRNA Translation: BAA87904.1
AF052059 mRNA Translation: AAF29413.1
AF157516 Genomic DNA Translation: AAF24176.1
AF198647
, AF198631, AF198632, AF198633, AF198634, AF198635, AF198636, AF198637, AF198638, AF198639, AF198640, AF198641, AF198642, AF198643, AF198644, AF198645, AF198646 Genomic DNA Translation: AAL40905.1
AY358651 mRNA Translation: AAQ89014.1
CCDSiCCDS58333.1 [Q9UBV2-2]
CCDS9876.1 [Q9UBV2-1]
RefSeqiNP_001231913.1, NM_001244984.1 [Q9UBV2-2]
NP_005056.3, NM_005065.5 [Q9UBV2-1]

3D structure databases

SMRiQ9UBV2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112300, 71 interactors
CORUMiQ9UBV2
DIPiDIP-46259N
IntActiQ9UBV2, 29 interactors
STRINGi9606.ENSP00000337053

Protein family/group databases

TCDBi3.A.16.1.4 the endoplasmic reticular retrotranslocon (er-rt) family

PTM databases

GlyConnecti1669
iPTMnetiQ9UBV2
PhosphoSitePlusiQ9UBV2
SwissPalmiQ9UBV2

Polymorphism and mutation databases

BioMutaiSEL1L
DMDMi62512184

Proteomic databases

EPDiQ9UBV2
jPOSTiQ9UBV2
MassIVEiQ9UBV2
PaxDbiQ9UBV2
PeptideAtlasiQ9UBV2
PRIDEiQ9UBV2
ProteomicsDBi84077 [Q9UBV2-1]
84078 [Q9UBV2-2]

Genome annotation databases

EnsembliENST00000336735; ENSP00000337053; ENSG00000071537 [Q9UBV2-1]
ENST00000555824; ENSP00000450709; ENSG00000071537 [Q9UBV2-2]
GeneIDi6400
KEGGihsa:6400
UCSCiuc001xvo.5 human [Q9UBV2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6400
DisGeNETi6400

GeneCards: human genes, protein and diseases

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GeneCardsi
SEL1L
HGNCiHGNC:10717 SEL1L
HPAiHPA024267
MIMi602329 gene
neXtProtiNX_Q9UBV2
OpenTargetsiENSG00000071537
PharmGKBiPA35639

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1550 Eukaryota
COG0790 LUCA
GeneTreeiENSGT00940000156671
HOGENOMiHOG000239927
InParanoidiQ9UBV2
KOiK14026
OMAiLAQMAMG
OrthoDBi357553at2759
PhylomeDBiQ9UBV2
TreeFamiTF315257

Enzyme and pathway databases

ReactomeiR-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-901032 ER Quality Control Compartment (ERQC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SEL1L human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SEL1L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6400
PharosiQ9UBV2

Protein Ontology

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PROi
PR:Q9UBV2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000071537 Expressed in 241 organ(s), highest expression level in duodenum
ExpressionAtlasiQ9UBV2 baseline and differential
GenevisibleiQ9UBV2 HS

Family and domain databases

CDDicd00062 FN2, 1 hit
Gene3Di1.25.40.10, 3 hits
2.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR006597 Sel1-like
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF08238 Sel1, 12 hits
SMARTiView protein in SMART
SM00059 FN2, 1 hit
SM00671 SEL1, 11 hits
SUPFAMiSSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSE1L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBV2
Secondary accession number(s): Q6UWT6, Q9P1T9, Q9UHK7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 12, 2005
Last modified: October 16, 2019
This is version 170 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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