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Entry version 180 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein

Zinc finger MYM-type protein 2

Gene

ZMYM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri352 – 386MYM-type 1Add BLAST35
Zinc fingeri398 – 436MYM-type 2Add BLAST39
Zinc fingeri445 – 480MYM-type 3Add BLAST36
Zinc fingeri491 – 549MYM-type 4Add BLAST59
Zinc fingeri559 – 597MYM-type 5Add BLAST39
Zinc fingeri605 – 652MYM-type 6Add BLAST48
Zinc fingeri660 – 694MYM-type 7Add BLAST35
Zinc fingeri701 – 740MYM-type 8Add BLAST40
Zinc fingeri747 – 781MYM-type 9Add BLAST35

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-5655302 Signaling by FGFR1 in disease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger MYM-type protein 2
Alternative name(s):
Fused in myeloproliferative disorders protein
Rearranged in atypical myeloproliferative disorder protein
Zinc finger protein 198
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZMYM2
Synonyms:FIM, RAMP, ZNF198
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12989 ZMYM2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602221 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBW7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ZMYM2 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with FGFR1. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei913 – 914Breakpoint for translocation to form ZMYM2-FGFR12

Organism-specific databases

DisGeNET

More...
DisGeNETi
7750

Open Targets

More...
OpenTargetsi
ENSG00000121741

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37569

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UBW7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZMYM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17369677

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001913821 – 1377Zinc finger MYM-type protein 2Add BLAST1377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki104Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei159PhosphoserineCombined sources1
Cross-linki253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei305PhosphoserineCombined sources1
Cross-linki312Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki503Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki513Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki529Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki532Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki576Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki603Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki649Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki658Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki688Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki700Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki709Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki764Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki788Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki812Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki829Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei838PhosphoserineCombined sources1
Modified residuei958PhosphoserineCombined sources1
Modified residuei1064PhosphoserineBy similarity1
Modified residuei1376PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UBW7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UBW7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UBW7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UBW7

PeptideAtlas

More...
PeptideAtlasi
Q9UBW7

PRoteomics IDEntifications database

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PRIDEi
Q9UBW7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84085 [Q9UBW7-1]
84086 [Q9UBW7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121741 Expressed in 234 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UBW7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBW7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031765

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
GTF2IRD1Q9UHL95EBI-2797576,EBI-372530

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113534, 82 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UBW7

Protein interaction database and analysis system

More...
IntActi
Q9UBW7, 61 interactors

Molecular INTeraction database

More...
MINTi
Q9UBW7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000479904

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri352 – 386MYM-type 1Add BLAST35
Zinc fingeri398 – 436MYM-type 2Add BLAST39
Zinc fingeri445 – 480MYM-type 3Add BLAST36
Zinc fingeri491 – 549MYM-type 4Add BLAST59
Zinc fingeri559 – 597MYM-type 5Add BLAST39
Zinc fingeri605 – 652MYM-type 6Add BLAST48
Zinc fingeri660 – 694MYM-type 7Add BLAST35
Zinc fingeri701 – 740MYM-type 8Add BLAST40
Zinc fingeri747 – 781MYM-type 9Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IE8I Eukaryota
ENOG410XQR6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157028

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UBW7

Identification of Orthologs from Complete Genome Data

More...
OMAi
SWETMEF

Database of Orthologous Groups

More...
OrthoDBi
587724at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBW7

TreeFam database of animal gene trees

More...
TreeFami
TF336988

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021893 DUF3504
IPR011017 TRASH_dom
IPR010507 Znf_MYM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12012 DUF3504, 1 hit
PF06467 zf-FCS, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00746 TRASH, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTSSVGGLE LTDQTPVLLG STAMATSLTN VGNSFSGPAN PLVSRSNKFQ
60 70 80 90 100
NSSVEDDDDV VFIEPVQPPP PSVPVVADQR TITFTSSKNE ELQGNDSKIT
110 120 130 140 150
PSSKELASQK GSVSETIVID DEEDMETNQG QEKNSSNFIE RRPPETKNRT
160 170 180 190 200
NDVDFSTSSF SRSKVNAGMG NSGITTEPDS EIQIANVTTL ETGVSSVNDG
210 220 230 240 250
QLENTDGRDM NLMITHVTSL QNTNLGDVSN GLQSSNFGVN IQTYTPSLTS
260 270 280 290 300
QTKTGVGPFN PGRMNVAGDV FQNGESATHH NPDSWISQSA SFPRNQKQPG
310 320 330 340 350
VDSLSPVASL PKQIFQPSVQ QQPTKPVKVT CANCKKPLQK GQTAYQRKGS
360 370 380 390 400
AHLFCSTTCL SSFSHKPAPK KLCVMCKKDI TTMKGTIVAQ VDSSESFQEF
410 420 430 440 450
CSTSCLSLYE DKQNPTKGAL NKSRCTICGK LTEIRHEVSF KNMTHKLCSD
460 470 480 490 500
HCFNRYRMAN GLIMNCCEQC GEYLPSKGAG NNVLVIDGQQ KRFCCQSCVS
510 520 530 540 550
EYKQVGSHPS FLKEVRDHMQ DSFLMQPEKY GKLTTCTGCR TQCRFFDMTQ
560 570 580 590 600
CIGPNGYMEP YCSTACMNSH KTKYAKSQSL GIICHFCKRN SLPQYQATMP
610 620 630 640 650
DGKLYNFCNS SCVAKFQALS MQSSPNGQFV APSDIQLKCN YCKNSFCSKP
660 670 680 690 700
EILEWENKVH QFCSKTCSDD YKKLHCIVTY CEYCQEEKTL HETVNFSGVK
710 720 730 740 750
RPFCSEGCKL LYKQDFARRL GLRCVTCNYC SQLCKKGATK ELDGVVRDFC
760 770 780 790 800
SEDCCKKFQD WYYKAARCDC CKSQGTLKER VQWRGEMKHF CDQHCLLRFY
810 820 830 840 850
CQQNEPNMTT QKGPENLHYD QGCQTSRTKM TGSAPPPSPT PNKEMKNKAV
860 870 880 890 900
LCKPLTMTKA TYCKPHMQTK SCQTDDTWRT EYVPVPIPVP VYIPVPMHMY
910 920 930 940 950
SQNIPVPTTV PVPVPVPVFL PAPLDSSEKI PAAIEELKSK VSSDALDTEL
960 970 980 990 1000
LTMTDMMSED EGKTETTNIN SVIIETDIIG SDLLKNSDPE TQSSMPDVPY
1010 1020 1030 1040 1050
EPDLDIEIDF PRAAEELDME NEFLLPPVFG EEYEEQPRPR SKKKGAKRKA
1060 1070 1080 1090 1100
VSGYQSHDDS SDNSECSFPF KYTYGVNAWK HWVKTRQLDE DLLVLDELKS
1110 1120 1130 1140 1150
SKSVKLKEDL LSHTTAELNY GLAHFVNEIR RPNGENYAPD SIYYLCLGIQ
1160 1170 1180 1190 1200
EYLCGSNRKD NIFIDPGYQT FEQELNKILR SWQPSILPDG SIFSRVEEDY
1210 1220 1230 1240 1250
LWRIKQLGSH SPVALLNTLF YFNTKYFGLK TVEQHLRLSF GTVFRHWKKN
1260 1270 1280 1290 1300
PLTMENKACL RYQVSSLCGT DNEDKITTGK RKHEDDEPVF EQIENTANPS
1310 1320 1330 1340 1350
RCPVKMFECY LSKSPQNLNQ RMDVFYLQPE CSSSTDSPVW YTSTSLDRNT
1360 1370
LENMLVRVLL VKDIYDKDNY ELDEDTD
Length:1,377
Mass (Da):154,911
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2652D4C766492FF9
GO
Isoform 2 (identifier: Q9UBW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-251: Missing.
     529-549: KYGKLTTCTGCRTQCRFFDMT → VSRNVNGVQGLNIFEHCYYCH
     550-1377: Missing.

Show »
Length:462
Mass (Da):50,809
Checksum:iE906383363CB8D65
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X151A0A087X151_HUMAN
Zinc finger MYM-type protein 2
ZMYM2
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB88464 differs from that shown. Reason: Frameshift.Curated
The sequence AAC23591 differs from that shown. Reason: Frameshift.Curated
The sequence CAA73875 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102S → P in CAH56193 (PubMed:11230166).Curated1
Sequence conflicti110K → E in AAH36372 (Ref. 7) Curated1
Sequence conflicti304L → V in CAB66556 (PubMed:11230166).Curated1
Sequence conflicti330T → S in CAB66556 (PubMed:11230166).Curated1
Sequence conflicti411 – 412DK → EQ in CAA73875 (PubMed:9576949).Curated2
Sequence conflicti424R → G in CAB66556 (PubMed:11230166).Curated1
Sequence conflicti736K → G in CAA73875 (PubMed:9576949).Curated1
Sequence conflicti856T → I in AAH36372 (Ref. 7) Curated1
Sequence conflicti967Missing in AAB88464 (PubMed:9694738).Curated1
Sequence conflicti1009 – 1010DF → IS in AAB88464 (PubMed:9694738).Curated2
Sequence conflicti1016Missing in AAB88464 (PubMed:9694738).Curated1
Sequence conflicti1259C → R in AAH36372 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039065165 – 251Missing in isoform 2. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_039066529 – 549KYGKL…FFDMT → VSRNVNGVQGLNIFEHCYYC H in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_039067550 – 1377Missing in isoform 2. 1 PublicationAdd BLAST828

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y13472 mRNA Translation: CAA73875.1 Frameshift.
AJ224901 mRNA Translation: CAA12204.1
AJ007676
, AJ007677, AJ007678, AJ007679, AJ007680, AJ007681, AJ007682, AJ007683, AJ007684, AJ007685, AJ007686, AJ007687, AJ007688, AJ007689, AJ007690, AJ007691, AJ007692, AJ007693, AJ007694, AJ007695, AJ007696 Genomic DNA Translation: CAA07604.1
AL136621 mRNA Translation: CAB66556.2
BX647944 mRNA Translation: CAH56193.1
AL137119 Genomic DNA No translation available.
AL138688 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08244.1
CH471075 Genomic DNA Translation: EAX08247.1
BC036372 mRNA Translation: AAH36372.1
AF060181 mRNA Translation: AAC23591.1 Frameshift.
AF035374 mRNA Translation: AAB88464.1 Frameshift.
AF012126 mRNA Translation: AAC01561.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS45016.1 [Q9UBW7-1]

Protein sequence database of the Protein Information Resource

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PIRi
T45119

NCBI Reference Sequences

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RefSeqi
NP_001177893.1, NM_001190964.2 [Q9UBW7-1]
NP_001177894.1, NM_001190965.2 [Q9UBW7-1]
NP_003444.1, NM_003453.4 [Q9UBW7-1]
NP_932072.1, NM_197968.3 [Q9UBW7-1]
XP_005266577.1, XM_005266520.3 [Q9UBW7-1]
XP_011533526.1, XM_011535224.2
XP_016876218.1, XM_017020729.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000382871; ENSP00000372324; ENSG00000121741 [Q9UBW7-1]
ENST00000382874; ENSP00000372327; ENSG00000121741 [Q9UBW7-1]
ENST00000610343; ENSP00000479904; ENSG00000121741 [Q9UBW7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7750

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7750

UCSC genome browser

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UCSCi
uc031zxt.2 human [Q9UBW7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13472 mRNA Translation: CAA73875.1 Frameshift.
AJ224901 mRNA Translation: CAA12204.1
AJ007676
, AJ007677, AJ007678, AJ007679, AJ007680, AJ007681, AJ007682, AJ007683, AJ007684, AJ007685, AJ007686, AJ007687, AJ007688, AJ007689, AJ007690, AJ007691, AJ007692, AJ007693, AJ007694, AJ007695, AJ007696 Genomic DNA Translation: CAA07604.1
AL136621 mRNA Translation: CAB66556.2
BX647944 mRNA Translation: CAH56193.1
AL137119 Genomic DNA No translation available.
AL138688 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08244.1
CH471075 Genomic DNA Translation: EAX08247.1
BC036372 mRNA Translation: AAH36372.1
AF060181 mRNA Translation: AAC23591.1 Frameshift.
AF035374 mRNA Translation: AAB88464.1 Frameshift.
AF012126 mRNA Translation: AAC01561.1
CCDSiCCDS45016.1 [Q9UBW7-1]
PIRiT45119
RefSeqiNP_001177893.1, NM_001190964.2 [Q9UBW7-1]
NP_001177894.1, NM_001190965.2 [Q9UBW7-1]
NP_003444.1, NM_003453.4 [Q9UBW7-1]
NP_932072.1, NM_197968.3 [Q9UBW7-1]
XP_005266577.1, XM_005266520.3 [Q9UBW7-1]
XP_011533526.1, XM_011535224.2
XP_016876218.1, XM_017020729.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi113534, 82 interactors
CORUMiQ9UBW7
IntActiQ9UBW7, 61 interactors
MINTiQ9UBW7
STRINGi9606.ENSP00000479904

PTM databases

iPTMnetiQ9UBW7
PhosphoSitePlusiQ9UBW7

Polymorphism and mutation databases

BioMutaiZMYM2
DMDMi17369677

Proteomic databases

EPDiQ9UBW7
jPOSTiQ9UBW7
MassIVEiQ9UBW7
PaxDbiQ9UBW7
PeptideAtlasiQ9UBW7
PRIDEiQ9UBW7
ProteomicsDBi84085 [Q9UBW7-1]
84086 [Q9UBW7-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7750

Genome annotation databases

EnsembliENST00000382871; ENSP00000372324; ENSG00000121741 [Q9UBW7-1]
ENST00000382874; ENSP00000372327; ENSG00000121741 [Q9UBW7-1]
ENST00000610343; ENSP00000479904; ENSG00000121741 [Q9UBW7-1]
GeneIDi7750
KEGGihsa:7750
UCSCiuc031zxt.2 human [Q9UBW7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7750
DisGeNETi7750

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZMYM2
HGNCiHGNC:12989 ZMYM2
HPAiHPA031765
MIMi602221 gene
neXtProtiNX_Q9UBW7
OpenTargetsiENSG00000121741
PharmGKBiPA37569

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE8I Eukaryota
ENOG410XQR6 LUCA
GeneTreeiENSGT00940000157028
InParanoidiQ9UBW7
OMAiSWETMEF
OrthoDBi587724at2759
PhylomeDBiQ9UBW7
TreeFamiTF336988

Enzyme and pathway databases

ReactomeiR-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-5655302 Signaling by FGFR1 in disease

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZMYM2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZMYM2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7750
PharosiQ9UBW7

Protein Ontology

More...
PROi
PR:Q9UBW7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000121741 Expressed in 234 organ(s), highest expression level in kidney
ExpressionAtlasiQ9UBW7 baseline and differential
GenevisibleiQ9UBW7 HS

Family and domain databases

InterProiView protein in InterPro
IPR021893 DUF3504
IPR011017 TRASH_dom
IPR010507 Znf_MYM
PfamiView protein in Pfam
PF12012 DUF3504, 1 hit
PF06467 zf-FCS, 8 hits
SMARTiView protein in SMART
SM00746 TRASH, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZMYM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBW7
Secondary accession number(s): A6NDG0
, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UEU2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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