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Entry version 133 (08 May 2019)
Sequence version 1 (01 May 2000)
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Protein

ProSAAS

Gene

PCSK1N

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeuropeptide

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I49.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ProSAAS
Alternative name(s):
Proprotein convertase subtilisin/kexin type 1 inhibitor
Short name:
Proprotein convertase 1 inhibitor
pro-SAAS
Cleaved into the following 7 chains:
Big SAAS
Short name:
b-SAAS
Little SAAS
Short name:
l-SAAS
Alternative name(s):
N-proSAAS
Big PEN-LEN
Short name:
b-PEN-LEN
Alternative name(s):
SAAS CT(1-49)
Little LEN
Short name:
l-LEN
Big LEN
Short name:
b-LEN
Alternative name(s):
SAAS CT(25-40)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCSK1N
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17301 PCSK1N

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300399 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UHG2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi235V → A: Reduces inhibition of PCSK1. 1 Publication1
Mutagenesisi236L → A: Greatly reduces inhibition of PCSK1. 1 Publication1
Mutagenesisi237G → A: Reduces inhibition of PCSK1. 1 Publication1
Mutagenesisi240L → A: Reduces inhibition of PCSK1. 1 Publication1
Mutagenesisi241R → A: Reduces inhibition of PCSK1. 1 Publication1
Mutagenesisi242V → A: Reduces inhibition of PCSK1. 1 Publication1
Mutagenesisi243K → A: Abolishes inhibition of PCSK1. 1 Publication1
Mutagenesisi244R → A: Abolishes inhibition of PCSK1. 1 Publication1
Mutagenesisi245L → A: Reduces inhibition of PCSK1. 1 Publication1
Mutagenesisi246E → A: Reduces inhibition of PCSK1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
27344

Open Targets

More...
OpenTargetsi
ENSG00000102109

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33090

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCSK1N

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74735013

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025967334 – 260ProSAASAdd BLAST227
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000025967534 – 59Big SAASBy similarityAdd BLAST26
PeptideiPRO_000025967434 – 40KEPBy similarity7
PeptideiPRO_000025967642 – 59Little SAASBy similarityAdd BLAST18
PeptideiPRO_0000259677221 – 260Big PEN-LENBy similarityAdd BLAST40
PeptideiPRO_0000259678221 – 242PENBy similarityAdd BLAST22
PeptideiPRO_0000259679245 – 260Big LENBy similarityAdd BLAST16
PeptideiPRO_0000259680245 – 254Little LENBy similarity10

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi53O-linked (GalNAc...) threonine2 Publications1
Glycosylationi228O-linked (GalNAc...) serine2 Publications1
Glycosylationi247O-linked (GalNAc...) threonine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved in the Golgi.1 Publication
O-glycosylated with a core 1 or possibly core 8 glycan.3 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UHG2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UHG2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UHG2

PeptideAtlas

More...
PeptideAtlasi
Q9UHG2

PRoteomics IDEntifications database

More...
PRIDEi
Q9UHG2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84349

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
743

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UHG2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UHG2

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q9UHG2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102109 Expressed in 150 organ(s), highest expression level in pituitary gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UHG2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003925
HPA064734

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts via the C-terminal inhibitory domain with PCSK1 66 kDa form.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118156, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UHG2, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9UHG2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000218230

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UHG2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni34 – 215ProSAAS(1-180)By similarityAdd BLAST182
Regioni221 – 260C-terminal inhibitory domain; interacts with PCSK1By similarityAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi239 – 244Sufficient for inhibition of PCSK16

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

ProSAAS(1-180) increases secretion of enzymatically inactive PCSK1.By similarity
The C-terminal inhibitory domain is involved in inhibition of PCSK1. It corresponds to the probable processing intermediate Big PEN-LEN, binds to PCSK1 in vitro and contains the hexapeptide L-L-R-V-K-R, which, as a synthetic peptide, is sufficient for PCSK1 inhibition (By similarity).By similarity

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWT4 Eukaryota
ENOG4111DVB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013488

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261638

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UHG2

Identification of Orthologs from Complete Genome Data

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OMAi
RPPIYDD

Database of Orthologous Groups

More...
OrthoDBi
1511698at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UHG2

TreeFam database of animal gene trees

More...
TreeFami
TF338201

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010832 ProSAAS

The PANTHER Classification System

More...
PANTHERi
PTHR15531 PTHR15531, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07259 ProSAAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UHG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGSPLLWGP RAGGVGLLVL LLLGLFRPPP ALCARPVKEP RGLSAASPPL
60 70 80 90 100
AETGAPRRFR RSVPRGEAAG AVQELARALA HLLEAERQER ARAEAQEAED
110 120 130 140 150
QQARVLAQLL RVWGAPRNSD PALGLDDDPD APAAQLARAL LRARLDPAAL
160 170 180 190 200
AAQLVPAPVP AAALRPRPPV YDDGPAGPDA EEAGDETPDV DPELLRYLLG
210 220 230 240 250
RILAGSADSE GVAAPRRLRR AADHDVGSEL PPEGVLGALL RVKRLETPAP
260
QVPARRLLPP
Length:260
Mass (Da):27,372
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF8E2722784B7A5C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02897131A → T1 PublicationCorresponds to variant dbSNP:rs11538176Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF181562 mRNA Translation: AAF22643.1
BC002851 mRNA Translation: AAH02851.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14307.1

NCBI Reference Sequences

More...
RefSeqi
NP_037403.1, NM_013271.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000218230; ENSP00000218230; ENSG00000102109

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27344

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27344

UCSC genome browser

More...
UCSCi
uc004dkz.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181562 mRNA Translation: AAF22643.1
BC002851 mRNA Translation: AAH02851.1
CCDSiCCDS14307.1
RefSeqiNP_037403.1, NM_013271.4

3D structure databases

SMRiQ9UHG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118156, 10 interactors
IntActiQ9UHG2, 2 interactors
MINTiQ9UHG2
STRINGi9606.ENSP00000218230

Protein family/group databases

MEROPSiI49.001

PTM databases

GlyConnecti743
iPTMnetiQ9UHG2
PhosphoSitePlusiQ9UHG2
UniCarbKBiQ9UHG2

Polymorphism and mutation databases

BioMutaiPCSK1N
DMDMi74735013

Proteomic databases

jPOSTiQ9UHG2
MaxQBiQ9UHG2
PaxDbiQ9UHG2
PeptideAtlasiQ9UHG2
PRIDEiQ9UHG2
ProteomicsDBi84349

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
27344
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218230; ENSP00000218230; ENSG00000102109
GeneIDi27344
KEGGihsa:27344
UCSCiuc004dkz.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27344
DisGeNETi27344

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PCSK1N
HGNCiHGNC:17301 PCSK1N
HPAiHPA003925
HPA064734
MIMi300399 gene
neXtProtiNX_Q9UHG2
OpenTargetsiENSG00000102109
PharmGKBiPA33090

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWT4 Eukaryota
ENOG4111DVB LUCA
GeneTreeiENSGT00390000013488
HOGENOMiHOG000261638
InParanoidiQ9UHG2
OMAiRPPIYDD
OrthoDBi1511698at2759
PhylomeDBiQ9UHG2
TreeFamiTF338201

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27344

Protein Ontology

More...
PROi
PR:Q9UHG2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102109 Expressed in 150 organ(s), highest expression level in pituitary gland
GenevisibleiQ9UHG2 HS

Family and domain databases

InterProiView protein in InterPro
IPR010832 ProSAAS
PANTHERiPTHR15531 PTHR15531, 1 hit
PfamiView protein in Pfam
PF07259 ProSAAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCSK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UHG2
Secondary accession number(s): Q4VC04
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 2000
Last modified: May 8, 2019
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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