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Entry version 167 (31 Jul 2019)
Sequence version 1 (01 May 2000)
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Protein

Hydroxyacid oxidase 1

Gene

HAO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FMNPROSITE-ProRule annotation1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=141 µM for glycolate1 Publication
  2. KM=40 µM for 2-hydroxy octanoate1 Publication
  3. KM=2200 µM for glyoxylate1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolate degradation

    This protein is involved in step 1 of the subpathway that synthesizes 3-phospho-D-glycerate from glycolate.
    Proteins known to be involved in the 4 steps of the subpathway in this organism are:
    1. Hydroxyacid oxidase 1 (HAO1)
    2. no protein annotated in this organism
    3. no protein annotated in this organism
    4. no protein annotated in this organism
    This subpathway is part of the pathway glycolate degradation, which is itself part of Organic acid metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3-phospho-D-glycerate from glycolate, the pathway glycolate degradation and in Organic acid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei26Substrate1
    Binding sitei108FMNPROSITE-ProRule annotation3 Publications1
    Binding sitei130FMNPROSITE-ProRule annotation3 Publications1
    Binding sitei132FMNPROSITE-ProRule annotation3 Publications1
    Binding sitei132Substrate1
    Binding sitei158FMNPROSITE-ProRule annotation3 Publications1
    Binding sitei167Substrate1
    Binding sitei236FMNPROSITE-ProRule annotation3 Publications1
    Binding sitei258FMNPROSITE-ProRule annotation3 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei260Proton acceptor1
    Binding sitei263Substrate1
    Binding sitei315FMNPROSITE-ProRule annotation3 Publications1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi291 – 315FMNPROSITE-ProRule annotationAdd BLAST25
    Nucleotide bindingi291 – 295FMN bindingPROSITE-ProRule annotation3 Publications5

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandFlavoprotein, FMN

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.1.3.15 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-389661 Glyoxylate metabolism and glycine degradation
    R-HSA-9033241 Peroxisomal protein import

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9UJM8

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00864;UER00830

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Hydroxyacid oxidase 1 (EC:1.1.3.15)
    Short name:
    HAOX1
    Alternative name(s):
    Glycolate oxidase
    Short name:
    GOX
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:HAO1
    Synonyms:GOX1, HAOX1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:4809 HAO1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    605023 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9UJM8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Peroxisome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    54363

    Open Targets

    More...
    OpenTargetsi
    ENSG00000101323

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA29185

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4229

    Drug and drug target database

    More...
    DrugBanki
    DB07907 (2S)-2-HYDROXYOCTANOIC ACID
    DB07060 3-(INDOL-3-YL) LACTATE
    DB03884 3-Phenylpyruvic Acid
    DB02279 Benzoylformic Acid
    DB02164 N-Sulfo-Flavin Mononucleotide
    DB03247 Riboflavin Monophosphate

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    HAO1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    13124294

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002063181 – 370Hydroxyacid oxidase 1Add BLAST370

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei184N6-succinyllysineBy similarity1
    Modified residuei194PhosphoserineBy similarity1
    Modified residuei230PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9UJM8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9UJM8

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9UJM8

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9UJM8

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    84633

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9UJM8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9UJM8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Liver.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000101323 Expressed in 15 organ(s), highest expression level in right lobe of liver

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9UJM8 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9UJM8 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA049552

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    119941, 4 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9UJM8, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000368066

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9UJM8

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1370
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9UJM8

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9UJM8

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 365FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST365

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi368 – 370Microbody targeting signalSequence analysis3

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0538 Eukaryota
    COG1304 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000018717

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000217463

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9UJM8

    KEGG Orthology (KO)

    More...
    KOi
    K11517

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    KSVYDYY

    Database of Orthologous Groups

    More...
    OrthoDBi
    879633at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9UJM8

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313363

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd02809 alpha_hydroxyacid_oxid_FMN, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.70, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013785 Aldolase_TIM
    IPR012133 Alpha-hydoxy_acid_DH_FMN
    IPR000262 FMN-dep_DH
    IPR037396 FMN_HAD
    IPR008259 FMN_hydac_DH_AS

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01070 FMN_dh, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000138 Al-hdrx_acd_dh, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
    PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q9UJM8-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLPRLICIND YEQHAKSVLP KSIYDYYRSG ANDEETLADN IAAFSRWKLY
    60 70 80 90 100
    PRMLRNVAET DLSTSVLGQR VSMPICVGAT AMQRMAHVDG ELATVRACQS
    110 120 130 140 150
    LGTGMMLSSW ATSSIEEVAE AGPEALRWLQ LYIYKDREVT KKLVRQAEKM
    160 170 180 190 200
    GYKAIFVTVD TPYLGNRLDD VRNRFKLPPQ LRMKNFETST LSFSPEENFG
    210 220 230 240 250
    DDSGLAAYVA KAIDPSISWE DIKWLRRLTS LPIVAKGILR GDDAREAVKH
    260 270 280 290 300
    GLNGILVSNH GARQLDGVPA TIDVLPEIVE AVEGKVEVFL DGGVRKGTDV
    310 320 330 340 350
    LKALALGAKA VFVGRPIVWG LAFQGEKGVQ DVLEILKEEF RLAMALSGCQ
    360 370
    NVKVIDKTLV RKNPLAVSKI
    Length:370
    Mass (Da):40,924
    Last modified:May 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC683C6F7CB5FD323
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF244134 mRNA Translation: AAF63219.1
    AF231916 mRNA Translation: AAF40199.1
    AL121739 mRNA Translation: CAB57329.1
    AB024079 mRNA Translation: BAA82872.1
    AL021879 Genomic DNA No translation available.
    BC113665 mRNA Translation: AAI13666.1
    BC113667 mRNA Translation: AAI13668.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS13100.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_060015.1, NM_017545.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000378789; ENSP00000368066; ENSG00000101323

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    54363

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:54363

    UCSC genome browser

    More...
    UCSCi
    uc002wmw.2 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF244134 mRNA Translation: AAF63219.1
    AF231916 mRNA Translation: AAF40199.1
    AL121739 mRNA Translation: CAB57329.1
    AB024079 mRNA Translation: BAA82872.1
    AL021879 Genomic DNA No translation available.
    BC113665 mRNA Translation: AAI13666.1
    BC113667 mRNA Translation: AAI13668.1
    CCDSiCCDS13100.1
    RefSeqiNP_060015.1, NM_017545.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2NZLX-ray1.35A1-370[»]
    2RDTX-ray1.95A1-370[»]
    2RDUX-ray1.65A1-370[»]
    2RDWX-ray1.95A1-370[»]
    2W0UX-ray2.84A/B/C/D1-370[»]
    5QIBX-ray1.48A1-368[»]
    5QICX-ray1.34A1-368[»]
    5QIDX-ray1.45A1-368[»]
    5QIEX-ray1.34A1-368[»]
    5QIFX-ray1.20A1-368[»]
    5QIGX-ray1.42A1-368[»]
    5QIHX-ray1.33A1-368[»]
    6GMBX-ray1.35A1-362[»]
    6GMCX-ray1.20A1-362[»]
    SMRiQ9UJM8
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi119941, 4 interactors
    IntActiQ9UJM8, 1 interactor
    STRINGi9606.ENSP00000368066

    Chemistry databases

    BindingDBiQ9UJM8
    ChEMBLiCHEMBL4229
    DrugBankiDB07907 (2S)-2-HYDROXYOCTANOIC ACID
    DB07060 3-(INDOL-3-YL) LACTATE
    DB03884 3-Phenylpyruvic Acid
    DB02279 Benzoylformic Acid
    DB02164 N-Sulfo-Flavin Mononucleotide
    DB03247 Riboflavin Monophosphate

    PTM databases

    iPTMnetiQ9UJM8
    PhosphoSitePlusiQ9UJM8

    Polymorphism and mutation databases

    BioMutaiHAO1
    DMDMi13124294

    Proteomic databases

    jPOSTiQ9UJM8
    PaxDbiQ9UJM8
    PeptideAtlasiQ9UJM8
    PRIDEiQ9UJM8
    ProteomicsDBi84633

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    54363
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000378789; ENSP00000368066; ENSG00000101323
    GeneIDi54363
    KEGGihsa:54363
    UCSCiuc002wmw.2 human

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    54363
    DisGeNETi54363

    GeneCards: human genes, protein and diseases

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    GeneCardsi
    HAO1
    HGNCiHGNC:4809 HAO1
    HPAiHPA049552
    MIMi605023 gene
    neXtProtiNX_Q9UJM8
    OpenTargetsiENSG00000101323
    PharmGKBiPA29185

    GenAtlas: human gene database

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    GenAtlasi
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    Phylogenomic databases

    eggNOGiKOG0538 Eukaryota
    COG1304 LUCA
    GeneTreeiENSGT00390000018717
    HOGENOMiHOG000217463
    InParanoidiQ9UJM8
    KOiK11517
    OMAiKSVYDYY
    OrthoDBi879633at2759
    PhylomeDBiQ9UJM8
    TreeFamiTF313363

    Enzyme and pathway databases

    UniPathwayiUPA00864;UER00830
    BRENDAi1.1.3.15 2681
    ReactomeiR-HSA-389661 Glyoxylate metabolism and glycine degradation
    R-HSA-9033241 Peroxisomal protein import
    SABIO-RKiQ9UJM8

    Miscellaneous databases

    EvolutionaryTraceiQ9UJM8

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    54363

    Protein Ontology

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    PROi
    PR:Q9UJM8

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000101323 Expressed in 15 organ(s), highest expression level in right lobe of liver
    ExpressionAtlasiQ9UJM8 baseline and differential
    GenevisibleiQ9UJM8 HS

    Family and domain databases

    CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
    Gene3Di3.20.20.70, 1 hit
    InterProiView protein in InterPro
    IPR013785 Aldolase_TIM
    IPR012133 Alpha-hydoxy_acid_DH_FMN
    IPR000262 FMN-dep_DH
    IPR037396 FMN_HAD
    IPR008259 FMN_hydac_DH_AS
    PfamiView protein in Pfam
    PF01070 FMN_dh, 1 hit
    PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
    PROSITEiView protein in PROSITE
    PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
    PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHAOX1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UJM8
    Secondary accession number(s): Q14CQ0, Q9UPZ0, Q9Y3I7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 2000
    Last modified: July 31, 2019
    This is version 167 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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