Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 180 (13 Nov 2019)
Sequence version 1 (01 May 2000)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Drebrin-like protein

Gene

DBNL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processAdaptive immunity, Endocytosis, Immunity, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9UJU6

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UJU6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Drebrin-like protein
Alternative name(s):
Cervical SH3P7
Cervical mucin-associated protein
Drebrin-F
HPK1-interacting protein of 55 kDa
Short name:
HIP-55
SH3 domain-containing protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DBNL
Synonyms:CMAP, SH3P7
ORF Names:PP5423
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2696 DBNL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610106 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UJU6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi361D → A: Abolishes cleavage by caspase-3. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
28988

Open Targets

More...
OpenTargetsi
ENSG00000136279

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27164

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UJU6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DBNL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51316115

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000797931 – 430Drebrin-like proteinAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphothreonineBy similarity1
Modified residuei160PhosphoserineCombined sources1
Modified residuei176N6-acetyllysineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei288N6-acetyllysineCombined sources1
Modified residuei291PhosphothreonineCombined sources1
Modified residuei334PhosphotyrosineBy similarity1
Modified residuei344PhosphotyrosineBy similarity1
Isoform 4 (identifier: Q9UJU6-4)
Modified residuei137PhosphoserineCombined sources1
Isoform 6 (identifier: Q9UJU6-6)
Modified residuei183PhosphoserineCombined sources1
Isoform 2 (identifier: Q9UJU6-2)
Modified residuei232PhosphoserineCombined sources1
Isoform 3 (identifier: Q9UJU6-3)
Modified residuei232PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Degraded by caspases during apoptosis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei361 – 362Cleavage; by caspase-32

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UJU6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UJU6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UJU6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UJU6

PeptideAtlas

More...
PeptideAtlasi
Q9UJU6

PRoteomics IDEntifications database

More...
PRIDEi
Q9UJU6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3878
3970
84659 [Q9UJU6-1]
84660 [Q9UJU6-2]
84661 [Q9UJU6-3]
8938

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9UJU6-2 [Q9UJU6-2]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
Q9UJU6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UJU6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UJU6

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9UJU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136279 Expressed in 182 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UJU6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UJU6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020265
HPA027735

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SHANK2, SHANK3 and SYN1.

Interacts with FGD1 and DNM1.

Interacts with ANKRD54.

Interacts with COBL.

Interacts with WASL and WIPF1 (By similarity).

Interacts with MAP4K1 and PRAM1.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118809, 69 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UJU6, 19 interactors

Molecular INTeraction database

More...
MINTi
Q9UJU6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417653

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1430
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UJU6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UJU6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 133ADF-HPROSITE-ProRule annotationAdd BLAST130
Domaini371 – 430SH3PROSITE-ProRule annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili176 – 231Sequence analysisAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABP1 family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3655 Eukaryota
ENOG410XRVX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008567

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UJU6

KEGG Orthology (KO)

More...
KOi
K20520

Identification of Orthologs from Complete Genome Data

More...
OMAi
GYEGQTN

Database of Orthologous Groups

More...
OrthoDBi
885776at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UJU6

TreeFam database of animal gene trees

More...
TreeFami
TF318935

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11960 SH3_Abp1_eu, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029923 Dbnl
IPR035717 Drebrin-like_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10829:SF12 PTHR10829:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00102 ADF, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51263 ADF_H, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UJU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAANLSRNGP ALQEAYVRVV TEKSPTDWAL FTYEGNSNDI RVAGTGEGGL
60 70 80 90 100
EEMVEELNSG KVMYAFCRVK DPNSGLPKFV LINWTGEGVN DVRKGACASH
110 120 130 140 150
VSTMASFLKG AHVTINARAE EDVEPECIME KVAKASGANY SFHKESGRFQ
160 170 180 190 200
DVGPQAPVGS VYQKTNAVSE IKRVGKDSFW AKAEKEEENR RLEEKRRAEE
210 220 230 240 250
AQRQLEQERR ERELREAARR EQRYQEQGGE ASPQRTWEQQ QEVVSRNRNE
260 270 280 290 300
QESAVHPREI FKQKERAMST TSISSPQPGK LRSPFLQKQL TQPETHFGRE
310 320 330 340 350
PAAAISRPRA DLPAEEPAPS TPPCLVQAEE EAVYEEPPEQ ETFYEQPPLV
360 370 380 390 400
QQQGAGSEHI DHHIQGQGLS GQGLCARALY DYQAADDTEI SFDPENLITG
410 420 430
IEVIDEGWWR GYGPDGHFGM FPANYVELIE
Length:430
Mass (Da):48,207
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E8C42ED047257AE
GO
Isoform 2 (identifier: Q9UJU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-234: Q → QS

Note: No experimental confirmation available.Combined sources
Show »
Length:431
Mass (Da):48,294
Checksum:iD18F9D316FFD0B4E
GO
Isoform 3 (identifier: Q9UJU6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-234: Q → QS
     251-251: Q → QGSTCASLQ

Note: No experimental confirmation available.Combined sources
Show »
Length:439
Mass (Da):49,042
Checksum:i8C044FBD0E82C6D5
GO
Isoform 4 (identifier: Q9UJU6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: MAANLSRNGP...HVSTMASFLK → MKATAMTSAWLAQG
     234-234: Q → QS

Show »
Length:336
Mass (Da):37,959
Checksum:iCDDA7B4BDFAADB32
GO
Isoform 5 (identifier: Q9UJU6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:327
Mass (Da):37,101
Checksum:iBE4C189EDD962834
GO
Isoform 6 (identifier: Q9UJU6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-158: Missing.
     234-234: Q → QS

Note: No experimental confirmation available.Combined sources
Show »
Length:382
Mass (Da):43,041
Checksum:i9B904F935E7107E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DDD6B4DDD6_HUMAN
Drebrin-like protein
DBNL
406Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5J4H0Y5J4_HUMAN
Drebrin-like protein
DBNL
359Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C111H7C111_HUMAN
Drebrin-like protein
DBNL
138Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WFE1F8WFE1_HUMAN
Drebrin-like protein
DBNL
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBG8F8WBG8_HUMAN
Drebrin-like protein
DBNL
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBB2F8WBB2_HUMAN
Drebrin-like protein
DBNL
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC20F8WC20_HUMAN
Drebrin-like protein
DBNL
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2V3F2Z2V3_HUMAN
Drebrin-like protein
DBNL
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3E3F2Z3E3_HUMAN
Drebrin-like protein
DBNL
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB73F8WB73_HUMAN
Drebrin-like protein
DBNL
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8N → K in AAG17262 (PubMed:15498874).Curated1
Sequence conflicti98A → S in AAF81273 (Ref. 3) Curated1
Sequence conflicti98A → S in AAG13120 (Ref. 3) Curated1
Sequence conflicti235R → S in AAF81273 (Ref. 3) Curated1
Sequence conflicti235R → S in AAG13120 (Ref. 3) Curated1
Sequence conflicti430E → D in CAG33448 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547791 – 109MAANL…ASFLK → MKATAMTSAWLAQG in isoform 4. CuratedAdd BLAST109
Alternative sequenceiVSP_0547801 – 103Missing in isoform 5. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_057346110 – 158Missing in isoform 6. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_011398234Q → QS in isoform 2, isoform 3, isoform 4 and isoform 6. 2 Publications1
Alternative sequenceiVSP_011399251Q → QGSTCASLQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF197060 mRNA Translation: AAF13701.1
AF077353 mRNA Translation: AAF80228.1
AF250287 mRNA Translation: AAF81273.1
AF151364 mRNA Translation: AAG13120.1
AF218020 mRNA Translation: AAG17262.2
AK027367 mRNA Translation: BAB55065.1
AK293279 mRNA Translation: BAG56807.1
AK293698 mRNA Translation: BAG57133.1
CR457167 mRNA Translation: CAG33448.1
AC017116 Genomic DNA No translation available.
CH236960 Genomic DNA Translation: EAL23770.1
CH471128 Genomic DNA Translation: EAW61132.1
BC011677 mRNA Translation: AAH11677.1
BC031687 mRNA Translation: AAH31687.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34622.1 [Q9UJU6-2]
CCDS34623.1 [Q9UJU6-1]
CCDS47579.1 [Q9UJU6-3]
CCDS64633.1 [Q9UJU6-4]
CCDS64634.1 [Q9UJU6-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001014436.1, NM_001014436.2 [Q9UJU6-1]
NP_001116428.1, NM_001122956.1 [Q9UJU6-3]
NP_001271242.1, NM_001284313.1 [Q9UJU6-5]
NP_001271244.1, NM_001284315.1 [Q9UJU6-4]
NP_054782.2, NM_014063.6 [Q9UJU6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000440166; ENSP00000415173; ENSG00000136279 [Q9UJU6-5]
ENST00000448521; ENSP00000411701; ENSG00000136279 [Q9UJU6-1]
ENST00000456905; ENSP00000416421; ENSG00000136279 [Q9UJU6-6]
ENST00000468694; ENSP00000417653; ENSG00000136279 [Q9UJU6-3]
ENST00000490734; ENSP00000417749; ENSG00000136279 [Q9UJU6-4]
ENST00000494774; ENSP00000419992; ENSG00000136279 [Q9UJU6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
28988

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:28988

UCSC genome browser

More...
UCSCi
uc003tjo.5 human [Q9UJU6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197060 mRNA Translation: AAF13701.1
AF077353 mRNA Translation: AAF80228.1
AF250287 mRNA Translation: AAF81273.1
AF151364 mRNA Translation: AAG13120.1
AF218020 mRNA Translation: AAG17262.2
AK027367 mRNA Translation: BAB55065.1
AK293279 mRNA Translation: BAG56807.1
AK293698 mRNA Translation: BAG57133.1
CR457167 mRNA Translation: CAG33448.1
AC017116 Genomic DNA No translation available.
CH236960 Genomic DNA Translation: EAL23770.1
CH471128 Genomic DNA Translation: EAW61132.1
BC011677 mRNA Translation: AAH11677.1
BC031687 mRNA Translation: AAH31687.1
CCDSiCCDS34622.1 [Q9UJU6-2]
CCDS34623.1 [Q9UJU6-1]
CCDS47579.1 [Q9UJU6-3]
CCDS64633.1 [Q9UJU6-4]
CCDS64634.1 [Q9UJU6-5]
RefSeqiNP_001014436.1, NM_001014436.2 [Q9UJU6-1]
NP_001116428.1, NM_001122956.1 [Q9UJU6-3]
NP_001271242.1, NM_001284313.1 [Q9UJU6-5]
NP_001271244.1, NM_001284315.1 [Q9UJU6-4]
NP_054782.2, NM_014063.6 [Q9UJU6-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X67NMR-A1-133[»]
SMRiQ9UJU6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi118809, 69 interactors
IntActiQ9UJU6, 19 interactors
MINTiQ9UJU6
STRINGi9606.ENSP00000417653

PTM databases

iPTMnetiQ9UJU6
PhosphoSitePlusiQ9UJU6

Polymorphism and mutation databases

BioMutaiDBNL
DMDMi51316115

2D gel databases

OGPiQ9UJU6

Proteomic databases

EPDiQ9UJU6
jPOSTiQ9UJU6
MassIVEiQ9UJU6
PaxDbiQ9UJU6
PeptideAtlasiQ9UJU6
PRIDEiQ9UJU6
ProteomicsDBi3878
3970
84659 [Q9UJU6-1]
84660 [Q9UJU6-2]
84661 [Q9UJU6-3]
8938
TopDownProteomicsiQ9UJU6-2 [Q9UJU6-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
28988

Genome annotation databases

EnsembliENST00000440166; ENSP00000415173; ENSG00000136279 [Q9UJU6-5]
ENST00000448521; ENSP00000411701; ENSG00000136279 [Q9UJU6-1]
ENST00000456905; ENSP00000416421; ENSG00000136279 [Q9UJU6-6]
ENST00000468694; ENSP00000417653; ENSG00000136279 [Q9UJU6-3]
ENST00000490734; ENSP00000417749; ENSG00000136279 [Q9UJU6-4]
ENST00000494774; ENSP00000419992; ENSG00000136279 [Q9UJU6-2]
GeneIDi28988
KEGGihsa:28988
UCSCiuc003tjo.5 human [Q9UJU6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
28988
DisGeNETi28988

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DBNL
HGNCiHGNC:2696 DBNL
HPAiHPA020265
HPA027735
MIMi610106 gene
neXtProtiNX_Q9UJU6
OpenTargetsiENSG00000136279
PharmGKBiPA27164

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3655 Eukaryota
ENOG410XRVX LUCA
GeneTreeiENSGT00940000156732
HOGENOMiHOG000008567
InParanoidiQ9UJU6
KOiK20520
OMAiGYEGQTN
OrthoDBi885776at2759
PhylomeDBiQ9UJU6
TreeFamiTF318935

Enzyme and pathway databases

ReactomeiR-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6798695 Neutrophil degranulation
SignaLinkiQ9UJU6
SIGNORiQ9UJU6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DBNL human
EvolutionaryTraceiQ9UJU6

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Drebrin-like

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
28988
PharosiQ9UJU6
PMAP-CutDBiQ9UJU6

Protein Ontology

More...
PROi
PR:Q9UJU6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136279 Expressed in 182 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiQ9UJU6 baseline and differential
GenevisibleiQ9UJU6 HS

Family and domain databases

CDDicd11960 SH3_Abp1_eu, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR029923 Dbnl
IPR035717 Drebrin-like_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10829:SF12 PTHR10829:SF12, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDBNL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UJU6
Secondary accession number(s): A4D2I9
, B4DDP6, B4DEM2, C9J7P1, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: November 13, 2019
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again