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Entry version 155 (13 Nov 2019)
Sequence version 3 (30 Nov 2010)
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Protein

Centrosomal protein of 131 kDa

Gene

CEP131

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).By similarity7 Publications

Miscellaneous

Transient cell cultured-based knock-down (by RNAi) of CEP131 leads to a reduction in ciliogenesis (PubMed:17954613, PubMed:24121310). However, analysis of mice with chronic absence of CEP131 following genetic deletion (knockout) shows that cilia develop and function normally in vivo. This suggests that CEP131 is not essential for ciliogenesis, except for the modified cilia of the developing sperm flagella, and that there is an alternative mechanism to compensate for the lack of CEP131.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Cilium biogenesis/degradation, Differentiation, Spermatogenesis, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 131 kDa
Alternative name(s):
5-azacytidine-induced protein 1
Pre-acrosome localization protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP131
Synonyms:AZI1, KIAA1118
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29511 CEP131

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613479 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPN4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi47S → A: Partially reduces in vitro phosphorylation by MAPKAPK2 and decreases binding to 14-3-3. Abolishes in vitro phosphorylation by MAPKAPK2, interaction with 14-3-3 and stress-induced centriolar satellite remodeling; when associated with A-78. 1 Publication1
Mutagenesisi78S → A: Partially reduces in vitro phosphorylation by MAPKAPK2 and decreases binding to 14-3-3. Abolishes in vitro phosphorylation by MAPKAPK2, interaction with 14-3-3 and stress-induced centriolar satellite remodeling; when associated with A-47. 1 Publication1
Mutagenesisi731S → A: No effect on interaction with 14-3-3. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
22994

Open Targets

More...
OpenTargetsi
ENSG00000141577

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA128394595
PA134920867

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UPN4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CEP131

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104247

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000647811 – 1083Centrosomal protein of 131 kDaAdd BLAST1083

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei47Phosphoserine; by MAPKAPK2Combined sources1
Modified residuei78Phosphoserine; by MAPKAPK2Combined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei150PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei383PhosphothreonineCombined sources1
Modified residuei453PhosphoserineCombined sources1
Modified residuei499PhosphoserineBy similarity1
Modified residuei731Phosphoserine1 Publication1
Modified residuei798PhosphoserineCombined sources1
Isoform 2 (identifier: Q9UPN4-2)
Modified residuei489PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Isoform 3 (identifier: Q9UPN4-3)
Modified residuei489PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. Undergoes monoubiquitination catalyzed by the E3 ubiquitin-protein ligase MIB1 in proliferating cells, preventing cilia formation. Monoubiquitination by MIB1 is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, resulting in cilia formation initiation.1 Publication
MAPKAPK2-dependent phosphorylation at Ser-47 and Ser-78 occurs in response to cellular stress such as exposure to ultraviolet irradiation and promotes binding to 14-3-3 proteins which leads to cytoplasmic sequestration of CEP131 and blocks formation of new centriolar satellites.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UPN4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UPN4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UPN4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UPN4

PeptideAtlas

More...
PeptideAtlasi
Q9UPN4

PRoteomics IDEntifications database

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PRIDEi
Q9UPN4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85387 [Q9UPN4-1]
85388 [Q9UPN4-2]
85389 [Q9UPN4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPN4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPN4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by the transcription factor SP1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000141577 Expressed in 104 organ(s), highest expression level in tendon of biceps brachii

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UPN4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UPN4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024019

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates. Associates with the centriolar satellite BBSome protein complex.

Interacts with BBS4; the interaction limits BBS4 availability for association with the BBSome complex, and hence negatively regulates ciliary localization of the BBSome complex (PubMed:24550735).

Interacts with MIB1 (PubMed:24121310).

Interacts with PCM1; the interaction increases in response to ultraviolet light (UV) radiation (PubMed:22797915, PubMed:24121310). Associates with microtubules; association with microtubules is reduced in response to cellular stress, such as UV stimulation, in a process that requires p38 MAP kinase signaling (PubMed:24121310).

Interacts with CEP290, DCTN1, PCNT, PCM1 and CEP152.

Interacts with 14-3-3 proteins following UV-induced phosphorylation by MAPKAPK2; this inhibits formation of novel centriolar satellites (PubMed:26616734).

Interacts with SDCCAG8 (PubMed:27224062).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116641, 124 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UPN4

Database of interacting proteins

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DIPi
DIP-56658N

Protein interaction database and analysis system

More...
IntActi
Q9UPN4, 108 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000393583

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UPN4

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini269 – 289IQAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP131 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEUN Eukaryota
ENOG410YVPU LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000001758

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000293266

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UPN4

KEGG Orthology (KO)

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KOi
K16540

Identification of Orthologs from Complete Genome Data

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OMAi
NSATQVN

Database of Orthologous Groups

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OrthoDBi
918776at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UPN4

TreeFam database of animal gene trees

More...
TreeFami
TF328914

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030465 CEP131

The PANTHER Classification System

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PANTHERi
PTHR31540 PTHR31540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGTRAIGSV PERSPAGVDL SLTGLPPPVS RRPGSAATTK PIVRSVSVVT
60 70 80 90 100
GSEQKRKVLE ATGPGGSQAI NNLRRSNSTT QVSQPRSGSP RPTEPTDFLM
110 120 130 140 150
LFEGSPSGKK RPASLSTAPS EKGATWNVLD DQPRGFTLPS NARSSSALDS
160 170 180 190 200
PAGPRRKECT VALAPNFTAN NRSNKGAVGN CVTTMVHNRY TPSERAPPLK
210 220 230 240 250
SSNQTAPSLN NIIKAATCEG SESSGFGKLP KNVSSATHSA RNNTGGSTGL
260 270 280 290 300
PRRKEVTEEE AERFIHQVNQ ATVTIQRWYR HQVQRRGAGA ARLEHLLQAK
310 320 330 340 350
REEQRQRSGE GTLLDLHQQK EAARRKAREE KARQARRAAI QELQQKRALR
360 370 380 390 400
AQKASTAERG PPENPRETRV PGMRQPAQEL SPTPGGTAHQ ALKANNTGGG
410 420 430 440 450
LPAAGPGDRC LPTSDSSPEP QQPPEDRTQD VLAQDAAGDN LEMMAPSRGS
460 470 480 490 500
AKSRGPLEEL LHTLQLLEKE PDVLPRPRTH HRGRYAWASE VTTEDDASSL
510 520 530 540 550
TADNLEKFGK LSAFPEPPED GTLLSEAKLQ SIMSFLDEME KSGQDQLDSQ
560 570 580 590 600
QEGWVPEAGP GPLELGSEVS TSVMRLKLEV EEKKQAMLLL QRALAQQRDL
610 620 630 640 650
TARRVKETEK ALSRQLQRQR EHYEATIQRH LAFIDQLIED KKVLSEKCEA
660 670 680 690 700
VVAELKQEDQ RCTERVAQAQ AQHELEIKKL KELMSATEKA RREKWISEKT
710 720 730 740 750
KKIKEVTVRG LEPEIQKLIA RHKQEVRRLK SLHEAELLQS DERASQRCLR
760 770 780 790 800
QAEELREQLE REKEALGQQE RERARQRFQQ HLEQEQWALQ QQRQRLYSEV
810 820 830 840 850
AEERERLGQQ AARQRAELEE LRQQLEESSS ALTRALRAEF EKGREEQERR
860 870 880 890 900
HQMELNTLKQ QLELERQAWE AGRTRKEEAW LLNREQELRE EIRKGRDKEI
910 920 930 940 950
ELVIHRLEAD MALAKEESEK AAESRIKRLR DKYEAELSEL EQSERKLQER
960 970 980 990 1000
CSELKGQLGE AEGENLRLQG LVRQKERALE DAQAVNEQLS SERSNLAQVI
1010 1020 1030 1040 1050
RQEFEDRLAA SEEETRQAKA ELATLQARQQ LELEEVHRRV KTALARKEEA
1060 1070 1080
VSSLRTQHEA AVKRADHLEE LLEQHRRPTP STK
Length:1,083
Mass (Da):122,149
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31C8CA426569CCAC
GO
Isoform 2 (identifier: Q9UPN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-493: Missing.

Show »
Length:1,080
Mass (Da):121,847
Checksum:i87E96867F87F0FC3
GO
Isoform 3 (identifier: Q9UPN4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-493: Missing.
     777-812: Missing.

Show »
Length:1,044
Mass (Da):117,397
Checksum:iE8307197B6D9111E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2J8I3L2J8_HUMAN
Centrosomal protein of 131 kDa
CEP131
1,047Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4M5I3L4M5_HUMAN
Centrosomal protein of 131 kDa
CEP131
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2X7I3L2X7_HUMAN
Centrosomal protein of 131 kDa
CEP131
524Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L316I3L316_HUMAN
Centrosomal protein of 131 kDa
CEP131
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83070 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05674043V → I. Corresponds to variant dbSNP:rs8067409Ensembl.1
Natural variantiVAR_06022670I → V. Corresponds to variant dbSNP:rs752612451Ensembl.1
Natural variantiVAR_060227272T → A2 PublicationsCorresponds to variant dbSNP:rs2466773Ensembl.1
Natural variantiVAR_060228397T → A2 PublicationsCorresponds to variant dbSNP:rs2659015Ensembl.1
Natural variantiVAR_060229473V → A2 PublicationsCorresponds to variant dbSNP:rs2659016Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015823491 – 493Missing in isoform 2 and isoform 3. 1 Publication3
Alternative sequenceiVSP_040204777 – 812Missing in isoform 3. CuratedAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB029041 mRNA Translation: BAA83070.1 Different initiation.
AC027601 Genomic DNA No translation available.
BC011615 mRNA Translation: AAH11615.2
BC136580 mRNA Translation: AAI36581.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32764.1 [Q9UPN4-3]
CCDS45808.1 [Q9UPN4-2]
CCDS82215.1 [Q9UPN4-1]

NCBI Reference Sequences

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RefSeqi
NP_001009811.2, NM_001009811.3 [Q9UPN4-3]
NP_001306157.1, NM_001319228.1 [Q9UPN4-1]
NP_055799.2, NM_014984.3 [Q9UPN4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000269392; ENSP00000269392; ENSG00000141577 [Q9UPN4-1]
ENST00000374782; ENSP00000363914; ENSG00000141577 [Q9UPN4-3]
ENST00000450824; ENSP00000393583; ENSG00000141577 [Q9UPN4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22994

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22994

UCSC genome browser

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UCSCi
uc002jzn.2 human [Q9UPN4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029041 mRNA Translation: BAA83070.1 Different initiation.
AC027601 Genomic DNA No translation available.
BC011615 mRNA Translation: AAH11615.2
BC136580 mRNA Translation: AAI36581.1
CCDSiCCDS32764.1 [Q9UPN4-3]
CCDS45808.1 [Q9UPN4-2]
CCDS82215.1 [Q9UPN4-1]
RefSeqiNP_001009811.2, NM_001009811.3 [Q9UPN4-3]
NP_001306157.1, NM_001319228.1 [Q9UPN4-1]
NP_055799.2, NM_014984.3 [Q9UPN4-2]

3D structure databases

SMRiQ9UPN4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116641, 124 interactors
CORUMiQ9UPN4
DIPiDIP-56658N
IntActiQ9UPN4, 108 interactors
STRINGi9606.ENSP00000393583

PTM databases

iPTMnetiQ9UPN4
PhosphoSitePlusiQ9UPN4

Polymorphism and mutation databases

BioMutaiCEP131
DMDMi313104247

Proteomic databases

EPDiQ9UPN4
jPOSTiQ9UPN4
MassIVEiQ9UPN4
PaxDbiQ9UPN4
PeptideAtlasiQ9UPN4
PRIDEiQ9UPN4
ProteomicsDBi85387 [Q9UPN4-1]
85388 [Q9UPN4-2]
85389 [Q9UPN4-3]

Genome annotation databases

EnsembliENST00000269392; ENSP00000269392; ENSG00000141577 [Q9UPN4-1]
ENST00000374782; ENSP00000363914; ENSG00000141577 [Q9UPN4-3]
ENST00000450824; ENSP00000393583; ENSG00000141577 [Q9UPN4-2]
GeneIDi22994
KEGGihsa:22994
UCSCiuc002jzn.2 human [Q9UPN4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22994
DisGeNETi22994

GeneCards: human genes, protein and diseases

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GeneCardsi
CEP131
HGNCiHGNC:29511 CEP131
HPAiHPA024019
MIMi613479 gene
neXtProtiNX_Q9UPN4
OpenTargetsiENSG00000141577
PharmGKBiPA128394595
PA134920867

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEUN Eukaryota
ENOG410YVPU LUCA
GeneTreeiENSGT00390000001758
HOGENOMiHOG000293266
InParanoidiQ9UPN4
KOiK16540
OMAiNSATQVN
OrthoDBi918776at2759
PhylomeDBiQ9UPN4
TreeFamiTF328914

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CEP131 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AZI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22994
PharosiQ9UPN4

Protein Ontology

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PROi
PR:Q9UPN4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141577 Expressed in 104 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiQ9UPN4 baseline and differential
GenevisibleiQ9UPN4 HS

Family and domain databases

InterProiView protein in InterPro
IPR030465 CEP131
PANTHERiPTHR31540 PTHR31540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP131_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPN4
Secondary accession number(s): A6NHI8, B2RN11, Q96F50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: November 30, 2010
Last modified: November 13, 2019
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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