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Entry version 142 (16 Oct 2019)
Sequence version 4 (18 May 2010)
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Protein

LIM and calponin homology domains-containing protein 1

Gene

LIMCH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LIM and calponin homology domains-containing protein 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIMCH1Imported
Synonyms:KIAA1102Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29191 LIMCH1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617750 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPQ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22998

Open Targets

More...
OpenTargetsi
ENSG00000064042

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162393957

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UPQ0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LIMCH1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439483

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002936191 – 1083LIM and calponin homology domains-containing protein 1Add BLAST1083

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei169PhosphoserineCombined sources1
Modified residuei177PhosphoserineBy similarity1
Modified residuei192PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei215PhosphothreonineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei226PhosphoserineBy similarity1
Modified residuei231PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei313PhosphotyrosineBy similarity1
Modified residuei377PhosphoserineCombined sources1
Modified residuei402PhosphothreonineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei472PhosphothreonineBy similarity1
Modified residuei516PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei529PhosphothreonineCombined sources1
Modified residuei537PhosphothreonineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1
Modified residuei718PhosphoserineCombined sources1
Modified residuei724PhosphothreonineCombined sources1
Modified residuei750PhosphoserineBy similarity1
Modified residuei756PhosphoserineBy similarity1
Modified residuei875PhosphoserineCombined sources1
Modified residuei900PhosphothreonineBy similarity1
Modified residuei966PhosphoserineCombined sources1
Modified residuei973PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UPQ0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UPQ0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UPQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPQ0

PeptideAtlas

More...
PeptideAtlasi
Q9UPQ0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UPQ0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20568
85402 [Q9UPQ0-1]
85403 [Q9UPQ0-2]
85404 [Q9UPQ0-3]
85405 [Q9UPQ0-4]
85406 [Q9UPQ0-5]
85407 [Q9UPQ0-6]
85408 [Q9UPQ0-7]
85409 [Q9UPQ0-8]
85410 [Q9UPQ0-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000064042 Expressed in 231 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UPQ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UPQ0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004184
HPA063840

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYH9; independently of the integration of MYH9 into the myosin complex.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116645, 54 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UPQ0, 29 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000316891

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UPQ0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 125Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST105
Domaini1011 – 1077LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni251 – 639Mediates interaction with MYH91 PublicationAdd BLAST389

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili354 – 439Sequence analysisAdd BLAST86
Coiled coili782 – 823Sequence analysisAdd BLAST42

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LIMCH1 family.Curated

Keywords - Domaini

Coiled coil, LIM domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INGA Eukaryota
ENOG410XQB9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183159

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UPQ0

Database of Orthologous Groups

More...
OrthoDBi
298177at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UPQ0

TreeFam database of animal gene trees

More...
TreeFami
TF332155

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001997 Calponin/LIMCH1
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR031865 DUF4757
IPR029980 LIMCH1
IPR003096 SM22_calponin
IPR001781 Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR15551:SF3 PTHR15551:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF15949 DUF4757, 1 hit
PF00412 LIM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00889 CALPONIN
PR00888 SM22CALPONIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACPALGLEA LQPLQPEPPP EPAFSEAQKW IEQVTGRSFG DKDFRTGLEN
60 70 80 90 100
GILLCELLNA IKPGLVKKIN RLPTPIAGLD NIILFLRGCK ELGLKESQLF
110 120 130 140 150
DPSDLQDTSN RVTVKSLDYS RKLKNVLVTI YWLGKAANSC TSYSGTTLNL
160 170 180 190 200
KEFEGLLAQM RKDTDDIESP KRSIRDSGYI DCWDSERSDS LSPPRHGRDD
210 220 230 240 250
SFDSLDSFGS RSRQTPSPDV VLRGSSDGRG SDSESDLPHR KLPDVKKDDM
260 270 280 290 300
SARRTSHGEP KSAVPFNQYL PNKSNQTAYV PAPLRKKKAE REEYRKSWST
310 320 330 340 350
ATSPLGGERP FRYGPRTPVS DDAESTSMFD MRCEEEAAVQ PHSRARQEQL
360 370 380 390 400
QLINNQLREE DDKWQDDLAR WKSRRRSVSQ DLIKKEEERK KMEKLLAGED
410 420 430 440 450
GTSERRKSIK TYREIVQEKE RRERELHEAY KNARSQEEAE GILQQYIERF
460 470 480 490 500
TISEAVLERL EMPKILERSH STEPNLSSFL NDPNPMKYLR QQSLPPPKFT
510 520 530 540 550
ATVETTIARA SVLDTSMSAG SGSPSKTVTP KAVPMLTPKP YSQPKNSQDV
560 570 580 590 600
LKTFKVDGKV SVNGETVHRE EEKERECPTV APAHSLTKSQ MFEGVARVHG
610 620 630 640 650
SPLELKQDNG SIEINIKKPN SVPQELAATT EKTEPNSQED KNDGGKSRKG
660 670 680 690 700
NIELASSEPQ HFTTTVTRCS PTVAFVEFPS SPQLKNDVSE EKDQKKPENE
710 720 730 740 750
MSGKVELVLS QKVVKPKSPE PEATLTFPFL DKMPEANQLH LPNLNSQVDS
760 770 780 790 800
PSSEKSPVMT PQFKFWAWDP EEERRRQEKW QQEQERLLQE RYQKEQDKLK
810 820 830 840 850
EEWEKAQKEV EEEERRYYEE ERKIIEDTVV PFTVSSSSAD QLSTSSSMTE
860 870 880 890 900
GSGTMNKIDL GNCQDEKQDR RWKKSFQGDD SDLLLKTRES DRLEEKGSLT
910 920 930 940 950
EGALAHSGNP VSKGVHEDHQ LDTEAGAPHC GTNPQLAQDP SQNQQTSNPT
960 970 980 990 1000
HSSEDVKPKT LPLDKSINHQ IESPSERRKK SPREHFQAGP FSPCSPTPPG
1010 1020 1030 1040 1050
QSPNRSISGK KLCSSCGLPL GKGAAMIIET LNLYFHIQCF RCGICKGQLG
1060 1070 1080
DAVSGTDVRI RNGLLNCNDC YMRSRSAGQP TTL
Length:1,083
Mass (Da):121,867
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19C8BA192EDBDC6B
GO
Isoform 2 (identifier: Q9UPQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     980-1005: Missing.

Show »
Length:1,057
Mass (Da):119,078
Checksum:i0941CE1DC5A787A8
GO
Isoform 3 (identifier: Q9UPQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     311-311: F → FSFPETIEEE...SSKGLPMKDQ
     762-762: Missing.

Note: No experimental confirmation available.
Show »
Length:1,467
Mass (Da):164,440
Checksum:i0D87F5D5CC068B60
GO
Isoform 4 (identifier: Q9UPQ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-324: Missing.
     747-747: Q → QESPGTASVPLRVQNSWRRSQFFSQS
     762-762: Missing.
     980-1005: Missing.

Note: No experimental confirmation available.
Show »
Length:1,069
Mass (Da):120,496
Checksum:iDFE247E4E66028D9
GO
Isoform 5 (identifier: Q9UPQ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     313-324: Missing.
     747-747: Q → QESPGTASVPLRVQNSWRRSQFFSQS
     762-762: Missing.
     980-1005: Missing.

Note: No experimental confirmation available.
Show »
Length:910
Mass (Da):103,010
Checksum:i569E37A38F29AB9A
GO
Isoform 6 (identifier: Q9UPQ0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.
     155-161: GLLAQMR → MDSERQV
     762-762: Missing.
     980-1005: Missing.

Show »
Length:902
Mass (Da):102,022
Checksum:i7584455BA8EAEC5D
GO
Isoform 7 (identifier: Q9UPQ0-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     288-297: KAEREEYRKS → NADTMRRSVR
     298-1083: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):15,551
Checksum:i7829A68BD11C1097
GO
Isoform 8 (identifier: Q9UPQ0-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     762-762: Missing.
     980-1005: Missing.

Show »
Length:897
Mass (Da):101,464
Checksum:iE6A5FF8C3D53D2F9
GO
Isoform 9 (identifier: Q9UPQ0-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.
     155-161: GLLAQMR → MDSERQV
     313-324: Missing.
     762-762: Missing.
     980-1005: Missing.

Show »
Length:890
Mass (Da):100,734
Checksum:iD0F8D08238E15CDD
GO
Isoform 10 (identifier: Q9UPQ0-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     762-762: Missing.
     980-1005: Missing.

Note: No experimental confirmation available.
Show »
Length:1,056
Mass (Da):118,950
Checksum:i69BBB44235180481
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD46D6RD46_HUMAN
LIM and calponin homology domains-c...
LIMCH1
980Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EA03G5EA03_HUMAN
LIM and calponin homology domains-c...
LIMCH1 DKFZP686A01247, hCG_33090
1,467Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PDJ9E9PDJ9_HUMAN
LIM and calponin homology domains-c...
LIMCH1
916Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPK0E7EPK0_HUMAN
LIM and calponin homology domains-c...
LIMCH1
897Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8P3H0Y8P3_HUMAN
LIM and calponin homology domains-c...
LIMCH1
917Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R8Y0D6R8Y0_HUMAN
LIM and calponin homology domains-c...
LIMCH1
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJ93D6RJ93_HUMAN
LIM and calponin homology domains-c...
LIMCH1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6NVB9Q6NVB9_HUMAN
LIM and calponin homology domains-c...
LIMCH1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGH8D6RGH8_HUMAN
LIM and calponin homology domains-c...
LIMCH1
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83054 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17E → G in CAI56749 (PubMed:17974005).Curated1
Sequence conflicti142S → P in CR936664 (PubMed:17974005).Curated1
Sequence conflicti207S → F in CAI56749 (PubMed:17974005).Curated1
Sequence conflicti409I → T in CR936664 (PubMed:17974005).Curated1
Sequence conflicti537T → I in CAH18063 (PubMed:17974005).Curated1
Sequence conflicti611S → G in CAD38604 (PubMed:17974005).Curated1
Sequence conflicti622V → I in CR936664 (PubMed:17974005).Curated1
Sequence conflicti706E → G in CAI56754 (PubMed:17974005).Curated1
Sequence conflicti750S → P in CAD38604 (PubMed:17974005).Curated1
Sequence conflicti867K → N in CAH18063 (PubMed:17974005).Curated1
Sequence conflicti1053V → A in CAD38604 (PubMed:17974005).Curated1
Sequence conflicti1059R → G in CAI45946 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033105759M → T3 PublicationsCorresponds to variant dbSNP:rs11734372Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0265411 – 159Missing in isoform 3, isoform 5, isoform 7 and isoform 8. 2 PublicationsAdd BLAST159
Alternative sequenceiVSP_0265421 – 154Missing in isoform 6 and isoform 9. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_026543155 – 161GLLAQMR → MDSERQV in isoform 6 and isoform 9. 1 Publication7
Alternative sequenceiVSP_026544288 – 297KAEREEYRKS → NADTMRRSVR in isoform 7. 1 Publication10
Alternative sequenceiVSP_026545298 – 1083Missing in isoform 7. 1 PublicationAdd BLAST786
Alternative sequenceiVSP_026546311F → FSFPETIEEEGSEVGSAGED NPAGQMNPGWKPSDGGCELP DGSGKEHPSSDGAVVAPAPK SEEKDAAEIQKRERLEQAGI KVMPAAQRFASQKQLSEEKE AIRDIVLRKENSFLTHQHGN DSEAEGEVVCRLPDLEKDDF AARRARMNQTKPMVPLNQLL YGPYPKKGAEKSDGSKQLSK GISKKRSLEYKRNQGHTEEV KLIVTCNMRAQESEPVEGGL RKVPDLHKDDLAQQRIQGSL APHREPPSFITLSNITEADL ETWERLKVSEKARDGDVQHI CASEPSPEIKAETAIRDDFA NRKARASKKASSPRQKFVHF GPVTELDQQKWKRLSIGKAG PREDEEEVICHGSKIQMDSV SPVSAATSSLKGHQIFNRQN DCRTMNCGRGDYCRRASWLA PVPESQEEWVCSLGECPRGT EEVTSKQLPQDGKEETESAP RDSERLSKAERSEDSSQPLV CPLASECEASGTEEKLEKMT APAWSGSGLKGQRKLDDSRK DDMMARRTGMSLRHTGSNPN QFLPVPFAKQQDVEESSKGL PMKDQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_026547313 – 324Missing in isoform 4, isoform 5 and isoform 9. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_026548747Q → QESPGTASVPLRVQNSWRRS QFFSQS in isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_026549762Missing in isoform 3, isoform 4, isoform 5, isoform 6, isoform 8, isoform 9 and isoform 10. 2 Publications1
Alternative sequenceiVSP_026550980 – 1005Missing in isoform 2, isoform 4, isoform 5, isoform 6, isoform 8, isoform 9 and isoform 10. 2 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029025 mRNA Translation: BAA83054.2 Different initiation.
AL831962 mRNA Translation: CAD38604.1
BX537916 mRNA Translation: CAD97899.1
CR749205 mRNA Translation: CAH18063.1
CR933645 mRNA Translation: CAI45946.1
CR936601 mRNA Translation: CAI56749.1
CR936610 mRNA Translation: CAI56754.1
CR936664 mRNA No translation available.
AC095043 Genomic DNA No translation available.
AC105389 Genomic DNA No translation available.
AC108050 Genomic DNA No translation available.
AC121159 Genomic DNA No translation available.
AC124009 Genomic DNA No translation available.
BC023546 mRNA Translation: AAH23546.1
BC029735 mRNA Translation: AAH29735.1
BC095394 mRNA Translation: AAH95394.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33977.1 [Q9UPQ0-1]
CCDS47047.1 [Q9UPQ0-6]
CCDS54763.1 [Q9UPQ0-2]
CCDS54764.1 [Q9UPQ0-10]
CCDS54765.1 [Q9UPQ0-9]
CCDS75119.1 [Q9UPQ0-4]
CCDS75121.1 [Q9UPQ0-5]
CCDS82919.1 [Q9UPQ0-3]
CCDS87222.1 [Q9UPQ0-8]

NCBI Reference Sequences

More...
RefSeqi
NP_001106188.1, NM_001112717.3 [Q9UPQ0-2]
NP_001106189.1, NM_001112718.3 [Q9UPQ0-10]
NP_001106190.1, NM_001112719.3 [Q9UPQ0-6]
NP_001106191.1, NM_001112720.3 [Q9UPQ0-9]
NP_001276051.1, NM_001289122.2 [Q9UPQ0-4]
NP_001276053.1, NM_001289124.1 [Q9UPQ0-5]
NP_001317601.1, NM_001330672.1
NP_001317603.1, NM_001330674.1
NP_001317713.1, NM_001330784.1
NP_001317715.1, NM_001330786.1 [Q9UPQ0-8]
NP_055803.2, NM_014988.4 [Q9UPQ0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313860; ENSP00000316891; ENSG00000064042 [Q9UPQ0-1]
ENST00000381753; ENSP00000371172; ENSG00000064042 [Q9UPQ0-9]
ENST00000396595; ENSP00000379840; ENSG00000064042 [Q9UPQ0-6]
ENST00000508501; ENSP00000424825; ENSG00000064042 [Q9UPQ0-10]
ENST00000511496; ENSP00000421242; ENSG00000064042 [Q9UPQ0-8]
ENST00000512820; ENSP00000424437; ENSG00000064042 [Q9UPQ0-4]
ENST00000512946; ENSP00000424645; ENSG00000064042 [Q9UPQ0-2]
ENST00000513024; ENSP00000425222; ENSG00000064042 [Q9UPQ0-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22998

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22998

UCSC genome browser

More...
UCSCi
uc003gvu.6 human [Q9UPQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029025 mRNA Translation: BAA83054.2 Different initiation.
AL831962 mRNA Translation: CAD38604.1
BX537916 mRNA Translation: CAD97899.1
CR749205 mRNA Translation: CAH18063.1
CR933645 mRNA Translation: CAI45946.1
CR936601 mRNA Translation: CAI56749.1
CR936610 mRNA Translation: CAI56754.1
CR936664 mRNA No translation available.
AC095043 Genomic DNA No translation available.
AC105389 Genomic DNA No translation available.
AC108050 Genomic DNA No translation available.
AC121159 Genomic DNA No translation available.
AC124009 Genomic DNA No translation available.
BC023546 mRNA Translation: AAH23546.1
BC029735 mRNA Translation: AAH29735.1
BC095394 mRNA Translation: AAH95394.1
CCDSiCCDS33977.1 [Q9UPQ0-1]
CCDS47047.1 [Q9UPQ0-6]
CCDS54763.1 [Q9UPQ0-2]
CCDS54764.1 [Q9UPQ0-10]
CCDS54765.1 [Q9UPQ0-9]
CCDS75119.1 [Q9UPQ0-4]
CCDS75121.1 [Q9UPQ0-5]
CCDS82919.1 [Q9UPQ0-3]
CCDS87222.1 [Q9UPQ0-8]
RefSeqiNP_001106188.1, NM_001112717.3 [Q9UPQ0-2]
NP_001106189.1, NM_001112718.3 [Q9UPQ0-10]
NP_001106190.1, NM_001112719.3 [Q9UPQ0-6]
NP_001106191.1, NM_001112720.3 [Q9UPQ0-9]
NP_001276051.1, NM_001289122.2 [Q9UPQ0-4]
NP_001276053.1, NM_001289124.1 [Q9UPQ0-5]
NP_001317601.1, NM_001330672.1
NP_001317603.1, NM_001330674.1
NP_001317713.1, NM_001330784.1
NP_001317715.1, NM_001330786.1 [Q9UPQ0-8]
NP_055803.2, NM_014988.4 [Q9UPQ0-1]

3D structure databases

SMRiQ9UPQ0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116645, 54 interactors
IntActiQ9UPQ0, 29 interactors
STRINGi9606.ENSP00000316891

PTM databases

iPTMnetiQ9UPQ0
PhosphoSitePlusiQ9UPQ0

Polymorphism and mutation databases

BioMutaiLIMCH1
DMDMi296439483

Proteomic databases

EPDiQ9UPQ0
jPOSTiQ9UPQ0
MassIVEiQ9UPQ0
PaxDbiQ9UPQ0
PeptideAtlasiQ9UPQ0
PRIDEiQ9UPQ0
ProteomicsDBi20568
85402 [Q9UPQ0-1]
85403 [Q9UPQ0-2]
85404 [Q9UPQ0-3]
85405 [Q9UPQ0-4]
85406 [Q9UPQ0-5]
85407 [Q9UPQ0-6]
85408 [Q9UPQ0-7]
85409 [Q9UPQ0-8]
85410 [Q9UPQ0-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22998

Genome annotation databases

EnsembliENST00000313860; ENSP00000316891; ENSG00000064042 [Q9UPQ0-1]
ENST00000381753; ENSP00000371172; ENSG00000064042 [Q9UPQ0-9]
ENST00000396595; ENSP00000379840; ENSG00000064042 [Q9UPQ0-6]
ENST00000508501; ENSP00000424825; ENSG00000064042 [Q9UPQ0-10]
ENST00000511496; ENSP00000421242; ENSG00000064042 [Q9UPQ0-8]
ENST00000512820; ENSP00000424437; ENSG00000064042 [Q9UPQ0-4]
ENST00000512946; ENSP00000424645; ENSG00000064042 [Q9UPQ0-2]
ENST00000513024; ENSP00000425222; ENSG00000064042 [Q9UPQ0-5]
GeneIDi22998
KEGGihsa:22998
UCSCiuc003gvu.6 human [Q9UPQ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22998
DisGeNETi22998

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LIMCH1
HGNCiHGNC:29191 LIMCH1
HPAiHPA004184
HPA063840
MIMi617750 gene
neXtProtiNX_Q9UPQ0
OpenTargetsiENSG00000064042
PharmGKBiPA162393957

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INGA Eukaryota
ENOG410XQB9 LUCA
GeneTreeiENSGT00950000183159
InParanoidiQ9UPQ0
OrthoDBi298177at2759
PhylomeDBiQ9UPQ0
TreeFamiTF332155

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LIMCH1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LIMCH1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22998
PharosiQ9UPQ0

Protein Ontology

More...
PROi
PR:Q9UPQ0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000064042 Expressed in 231 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ9UPQ0 baseline and differential
GenevisibleiQ9UPQ0 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001997 Calponin/LIMCH1
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR031865 DUF4757
IPR029980 LIMCH1
IPR003096 SM22_calponin
IPR001781 Znf_LIM
PANTHERiPTHR15551:SF3 PTHR15551:SF3, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF15949 DUF4757, 1 hit
PF00412 LIM, 1 hit
PRINTSiPR00889 CALPONIN
PR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00132 LIM, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIMC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPQ0
Secondary accession number(s): A8MXC3
, E9PHM7, Q503B5, Q5CZB1, Q5CZB6, Q5H9S8, Q68E07, Q6PJ44, Q7Z3G5, Q8N3S9, Q8N6M2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 142 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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