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Entry version 152 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein

Transcription elongation factor SPT5

Gene

Spt5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-112382 Formation of RNA Pol II elongation complex
R-DME-113418 Formation of the Early Elongation Complex
R-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-DME-6807505 RNA polymerase II transcribes snRNA genes
R-DME-72086 mRNA Capping
R-DME-75955 RNA Polymerase II Transcription Elongation
R-DME-77075 RNA Pol II CTD phosphorylation and interaction with CE

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription elongation factor SPT5
Alternative name(s):
DRB sensitivity-inducing factor large subunit
Short name:
DSIF large subunit
dSpt5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spt5
ORF Names:CG7626
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0040273 Spt5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi994G → D in allele WO49; impedes segmental patterning of the embryo and the heat shock response. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002084731 – 1078Transcription elongation factor SPT5Add BLAST1078

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei73Phosphoserine1 Publication1
Modified residuei76Phosphoserine1 Publication1
Modified residuei90Phosphoserine1 Publication1
Modified residuei162Phosphothreonine1 Publication1
Modified residuei707Phosphoserine1 Publication1
Modified residuei808Phosphothreonine1 Publication1
Modified residuei815Phosphothreonine; by CDK9By similarity1
Modified residuei825Phosphothreonine; by CDK9By similarity1
Modified residuei847Phosphothreonine1 Publication1
Modified residuei855Phosphothreonine1 Publication1
Modified residuei867Phosphothreonine1 Publication1
Modified residuei868Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation by P-TEFb alleviates transcriptional pausing (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9V460

PRoteomics IDEntifications database

More...
PRIDEi
Q9V460

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9V460

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0040273 Expressed in 31 organ(s), highest expression level in embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9V460 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Spt6.

Interacts with Spt4 to form DSIF. DSIF interacts with trx, RNA polymerase II and with the FACT complex, which is composed of dre4/Spt16 and Ssrp/Ssrp1. DSIF can also interact with the exosome, a complex with 3'-5' exoribonuclease activity which is composed of at least Csl4, Dis3, Mtr3, Rrp4, Rrp6, Rrp40, Rrp42, Rrp46 and Ski6. DSIF may also interact with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of Cdk9 and cyclin-T (CycT).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9TVQ52EBI-134850,EBI-165626

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
72729, 19 interactors

Database of interacting proteins

More...
DIPi
DIP-59538N

Protein interaction database and analysis system

More...
IntActi
Q9V460, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0085716

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9V460

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 336KOW 1Add BLAST28
Domaini460 – 487KOW 2Add BLAST28
Domaini513 – 545KOW 3Add BLAST33
Domaini635 – 668KOW 4Add BLAST34
Domaini740 – 773KOW 5Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni213 – 307Interaction with Spt4By similarityAdd BLAST95
Regioni350 – 461Interaction with RNA polymerase IIBy similarityAdd BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 63Ser-richAdd BLAST62
Compositional biasi75 – 175Glu-richAdd BLAST101
Compositional biasi882 – 961Pro-richAdd BLAST80

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPT5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1999 Eukaryota
COG5164 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000037640

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9V460

KEGG Orthology (KO)

More...
KOi
K15172

Identification of Orthologs from Complete Genome Data

More...
OMAi
GYMNTPS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9V460

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06081 KOW_Spt5_1, 1 hit
cd06082 KOW_Spt5_2, 1 hit
cd06083 KOW_Spt5_3, 1 hit
cd06084 KOW_Spt5_4, 1 hit
cd06085 KOW_Spt5_5, 1 hit
cd06086 KOW_Spt5_6, 1 hit
cd09888 NGN_Euk, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 3 hits
3.30.70.940, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005824 KOW
IPR041973 KOW_Spt5_1
IPR041975 KOW_Spt5_2
IPR041976 KOW_Spt5_3
IPR041977 KOW_Spt5_4
IPR041978 KOW_Spt5_5
IPR041980 KOW_Spt5_6
IPR005100 NGN-domain
IPR006645 NGN_dom
IPR036735 NGN_dom_sf
IPR039385 NGN_Euk
IPR014722 Rib_L2_dom2
IPR039659 SPT5
IPR024945 Spt5_C_dom
IPR022581 Spt5_N
IPR017071 TF_Spt5_eukaryote
IPR008991 Translation_prot_SH3-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11125 PTHR11125, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00467 KOW, 1 hit
PF03439 Spt5-NGN, 1 hit
PF11942 Spt5_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036945 Spt5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01104 CTD, 1 hit
SM00739 KOW, 6 hits
SM00738 NGN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50104 SSF50104, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q9V460-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDSEVSNMS DSGSEDGSIS NKSQRSARSK SRSRSRSGSR GSRSVSRSRS
60 70 80 90 100
RSQSGHSRSG SESPQRRDNR GKSDESGEEE EEPPGEDIDS EEYDEEENDD
110 120 130 140 150
HPRKKKKKER FGGFIIDEAE VDDEVDEDDE WEEGANEIGI VGNEIDELGP
160 170 180 190 200
TARDIEIRRR GTNLWDTQKE DEIEEYLRKK YADESIAKRH FGDGGEEMSD
210 220 230 240 250
EITQQTLLPG IKDPNLWMVK CRIGEEKATA LLLMRKYLTY LNTDDPLQIK
260 270 280 290 300
SIIAPEGVKG YIYLEAYKQT HVKTCIDNVG NLRMGKWKQE MVPIKEMTDV
310 320 330 340 350
LKVVKEQVGL KVKQWVRLKR GLYKDDIAQV DYVDLAQNQV HLKLLPRIDY
360 370 380 390 400
TRMRGALRTT ATESDDSKRK KKRRPAAKPF DPEAVRAIGG EVHSDGDFLL
410 420 430 440 450
FEGNRYSRKG FLYKNFTMSA ILSDGVKPTL AELERFEESP EEVNLEIMGT
460 470 480 490 500
VKDDPTMAHS FSMGDNVEVC VGDLENLQAK IVAIDGTMIT VMPKHQDLKD
510 520 530 540 550
PLIFKASELR KYFKTGDHAR VLAGRYEGET GLIIRVEPTR VVLVSDLTNH
560 570 580 590 600
ELEVLPRDLQ LCSDVATGVD CLGQFQWGDM VQLDSQNVGV IVRLERENFH
610 620 630 640 650
VLGMNGKCIE CKPTALHKRK ENRHTVALDA DQNQIRRRDV VKVMEGPHAG
660 670 680 690 700
RSGEIKHLYR SLAFLHCRMY TENGGIFVCK TRHLQLAGGS KTTVSNAGIV
710 720 730 740 750
GGLGFMSPRI QSPMHPSGGR GARGGARGGR GGFRVTRDRE ILGKTIKISG
760 770 780 790 800
GPYKGAVGIV KDATESTARV ELHTSCQTIS VDRNHIAIVG VTGKEGSVST
810 820 830 840 850
YGRTPARTPG YGAQTPSYTA AGSKTPLVGS QTPNWDTDTR TPYGTMTPSH
860 870 880 890 900
DGSMTPRHGA WDPTANTTPA RNNDFDYSLE EPSPSPGYNP STPGYQMTSQ
910 920 930 940 950
FAPQTPGTLY GSDRSYSPFN PSPSPAPSPY PVGYMNTPSP STYSPNTPGG
960 970 980 990 1000
IPQSPYNPQT PGASLDSSMG DWCTTDIEVR IHTHDDTDLV GQTGIIRTVS
1010 1020 1030 1040 1050
NGVCSVFLRQ EDRSVSIVSE HLAPVLPCNG DEFKIIYGDD RESVGRVLSK
1060 1070
DGDVFVCRIN EEIKLLPINF LCKMKSID
Length:1,078
Mass (Da):119,445
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B917AEE0C0ADD13
GO
Isoform B (identifier: Q9V460-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     488-603: Missing.

Note: No experimental confirmation available.
Show »
Length:962
Mass (Da):106,333
Checksum:i17C61F10373EB7FE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL39285 differs from that shown. Reason: Frameshift.Curated
The sequence AAL39285 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016285488 – 603Missing in isoform B. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF222864 mRNA Translation: AAF34689.1
AE013599 Genomic DNA Translation: AAF57561.1
AY069140 mRNA Translation: AAL39285.1 Sequence problems.
BT001668 mRNA Translation: AAN71423.1
BT023840 mRNA Translation: AAZ86761.1

NCBI Reference Sequences

More...
RefSeqi
NP_652610.1, NM_144353.4 [Q9V460-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086531; FBpp0085716; FBgn0040273 [Q9V460-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
53442

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7626

UCSC genome browser

More...
UCSCi
CG7626-RA d. melanogaster [Q9V460-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222864 mRNA Translation: AAF34689.1
AE013599 Genomic DNA Translation: AAF57561.1
AY069140 mRNA Translation: AAL39285.1 Sequence problems.
BT001668 mRNA Translation: AAN71423.1
BT023840 mRNA Translation: AAZ86761.1
RefSeqiNP_652610.1, NM_144353.4 [Q9V460-1]

3D structure databases

SMRiQ9V460
ModBaseiSearch...

Protein-protein interaction databases

BioGridi72729, 19 interactors
DIPiDIP-59538N
IntActiQ9V460, 7 interactors
STRINGi7227.FBpp0085716

PTM databases

iPTMnetiQ9V460

Proteomic databases

PaxDbiQ9V460
PRIDEiQ9V460

Genome annotation databases

EnsemblMetazoaiFBtr0086531; FBpp0085716; FBgn0040273 [Q9V460-1]
GeneIDi53442
KEGGidme:Dmel_CG7626
UCSCiCG7626-RA d. melanogaster [Q9V460-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
53442
FlyBaseiFBgn0040273 Spt5

Phylogenomic databases

eggNOGiKOG1999 Eukaryota
COG5164 LUCA
GeneTreeiENSGT00440000037640
InParanoidiQ9V460
KOiK15172
OMAiGYMNTPS
PhylomeDBiQ9V460

Enzyme and pathway databases

ReactomeiR-DME-112382 Formation of RNA Pol II elongation complex
R-DME-113418 Formation of the Early Elongation Complex
R-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-DME-6807505 RNA polymerase II transcribes snRNA genes
R-DME-72086 mRNA Capping
R-DME-75955 RNA Polymerase II Transcription Elongation
R-DME-77075 RNA Pol II CTD phosphorylation and interaction with CE

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
53442

Protein Ontology

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PROi
PR:Q9V460

Gene expression databases

BgeeiFBgn0040273 Expressed in 31 organ(s), highest expression level in embryo
GenevisibleiQ9V460 DM

Family and domain databases

CDDicd06081 KOW_Spt5_1, 1 hit
cd06082 KOW_Spt5_2, 1 hit
cd06083 KOW_Spt5_3, 1 hit
cd06084 KOW_Spt5_4, 1 hit
cd06085 KOW_Spt5_5, 1 hit
cd06086 KOW_Spt5_6, 1 hit
cd09888 NGN_Euk, 1 hit
Gene3Di2.30.30.30, 3 hits
3.30.70.940, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR041973 KOW_Spt5_1
IPR041975 KOW_Spt5_2
IPR041976 KOW_Spt5_3
IPR041977 KOW_Spt5_4
IPR041978 KOW_Spt5_5
IPR041980 KOW_Spt5_6
IPR005100 NGN-domain
IPR006645 NGN_dom
IPR036735 NGN_dom_sf
IPR039385 NGN_Euk
IPR014722 Rib_L2_dom2
IPR039659 SPT5
IPR024945 Spt5_C_dom
IPR022581 Spt5_N
IPR017071 TF_Spt5_eukaryote
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11125 PTHR11125, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 1 hit
PF03439 Spt5-NGN, 1 hit
PF11942 Spt5_N, 1 hit
PIRSFiPIRSF036945 Spt5, 1 hit
SMARTiView protein in SMART
SM01104 CTD, 1 hit
SM00739 KOW, 6 hits
SM00738 NGN, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPT5H_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V460
Secondary accession number(s): Q8IGQ1, Q8T0P5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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