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Entry version 147 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein

Polycomb protein Asx

Gene

Asx

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Atypical Polycomb group protein, which may be involved in both Polycomb group (PcG) and trithorax group (trxG) complexes. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PcG and trxG proteins act by forming multiprotein complexes, which are respectively required to maintain the transcriptionally repressive and transcriptionally active state of homeotic genes throughout development. PcG and trxG protein complexes are not required to initiate repression and activation, but to maintain it during later stages of development.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1632 – 1669PHD-type; atypicalAdd BLAST38

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5689603 UCH proteinases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycomb protein Asx
Alternative name(s):
Additional sex combs
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Asx
ORF Names:CG8787
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261823 Asx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000593231 – 1669Polycomb protein AsxAdd BLAST1669

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9V727

PRoteomics IDEntifications database

More...
PRIDEi
Q9V727

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in nurse cells and deposited in oocytes late in oogenesis. Ubiquitous in early embryos. Late embryos show higher levels in CNS and neurectoderm.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Early embryos have high levels of expression, this drops off and zygotic expression begins at 3-6 hours embryos. Expression levels are low in larvae and medium in pupae and adults.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261823 Expressed in 30 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9V727 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9V727 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the PR-DUB complex, at least composed of calypso and Asx (PubMed:20436459).

Interacts with tant (PubMed:11397012).

Interacts with cyclin CycG (PubMed:25995770).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
62360, 19 interactors

Database of interacting proteins

More...
DIPi
DIP-22881N

Protein interaction database and analysis system

More...
IntActi
Q9V727, 10 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305149

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11669
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9V727

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi224 – 228LXXLL motif 15
Motifi244 – 248LXXLL motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 12Poly-Thr5
Compositional biasi122 – 126Poly-Gln5
Compositional biasi129 – 152Ala-richAdd BLAST24
Compositional biasi638 – 715Ser-richAdd BLAST78
Compositional biasi747 – 751Poly-Gln5
Compositional biasi862 – 1202Gln-richAdd BLAST341
Compositional biasi1287 – 1290Poly-Thr4
Compositional biasi1520 – 1524Poly-His5
Compositional biasi1527 – 1536Poly-Gln10

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Asx family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1632 – 1669PHD-type; atypicalAdd BLAST38

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIF3 Eukaryota
ENOG4111F3G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055578

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9V727

KEGG Orthology (KO)

More...
KOi
K11471

Identification of Orthologs from Complete Genome Data

More...
OMAi
FADTIDH

Database of Orthologous Groups

More...
OrthoDBi
552046at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9V727

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026905 ASX-like_PHD
IPR024811 ASX/ASX-like
IPR028020 ASXH
IPR024814 Polycomb_ASX

The PANTHER Classification System

More...
PANTHERi
PTHR13578 PTHR13578, 1 hit
PTHR13578:SF20 PTHR13578:SF20, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13919 ASXH, 1 hit
PF13922 PHD_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9V727-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTITPDTTT TTSSQHQQLL IPQADQHHQP MLQQQSLLAA PPPTMIMEHV
60 70 80 90 100
NLVDDDEKDP LALEQLEVSP STKHTHSLRR HLPRIIVKPI PPEKKPMAPS
110 120 130 140 150
EEAAVSTAPA PPTRLICSRR IQQQQQVKAA AAAAAAAAAA AAAAAAAAQA
160 170 180 190 200
QATSSYPSAI SPGSKAGTSQ ASTMREVLAS IPGFSVKPRR RSNKKLTTAA
210 220 230 240 250
QIEQTKDGKI DLETPDSILA STNLRALLNK QTFSLLPPLY QYNLIQLLPS
260 270 280 290 300
VDREASELEQ PSSSASGGSP SEAIRLSASC LNNEFFARAC LEWRERLSEG
310 320 330 340 350
EFTPENQLKL KTEAEREKNK LDPWKLKHFE PFWGEKNSRG KDKDKLESDC
360 370 380 390 400
KNQKLSASIK SEPKPPATSQ QKPLQQATCD NETELKFDLS TKCETTSAKT
410 420 430 440 450
TVAVAVADKS STFPPTGSQN NVLNEQQRRV LKRPSSSPSQ RKQAPTTIAT
460 470 480 490 500
INLDDDLDEL PSTSKDSKQP KMDEIVPNAS GNVVAAPMVD VVDHSAVEMK
510 520 530 540 550
IKDEQQHQRQ HQPLINSTCD KIEPSECSKE MIVAMKQVDS KEDVDSIASA
560 570 580 590 600
AAMPAIAAVT PHTPKPEALA PNPDVANQFV SYLQNVELAA ETKAPLDNSN
610 620 630 640 650
EADITTGTNS HDFVFSDTID HAYFQEHQST INHNFFTSSS SSNTATTAAN
660 670 680 690 700
KLEEHSDKPE DSPLPIASSI SGSTPASSIT STSCTSSSSS SASMSSSCSS
710 720 730 740 750
SNSGSTTTAP TTSSSAGAPT APLTLAAAAE TTLANVQAML STVAKLQQQQ
760 770 780 790 800
QELPVELNSN EMYQHVQHDW NFGDIKLSSS QSSGDQQRNL SHEAIDLMDV
810 820 830 840 850
VQDADVIDDI MHNDVCHDVL GDEDEGDQEE DEDDEVVECM TEEQQLIDED
860 870 880 890 900
SEAVREIVDK LQQHQQQQNQ QQHHQQLHIQ DVVQLAQHSF MPQAHSEFGN
910 920 930 940 950
DIGQEMLCDA VPMSAAEMEV SSTVITNSSN SNDSSNNISL CSSTNSLTIN
960 970 980 990 1000
QMPHQASQQP QQNAQSNAQQ QRQILVDSNG QIIGNFLLQQ QRQQQQQQLL
1010 1020 1030 1040 1050
QQFTLQAAAA QQQQQQQQQH QQQQQQQQQA TSSNSLGKTL PVALRNGTQQ
1060 1070 1080 1090 1100
FLSPNLIAQQ HQQQQQQQLE QHQQQATAQQ KHQQIQQFAL QQAQLHQRQL
1110 1120 1130 1140 1150
LAQAANNNLL QQQQQQQQNV ALPTTQAKFI AKPLNIISMT RPANASPTTA
1160 1170 1180 1190 1200
ATTANTASIP SAYANVVAVT GAQQQQSPPV PAPQQQTVQQ QQLANHNSNM
1210 1220 1230 1240 1250
QQLPNVLTMK TLPPSGVPTT IAQQRLQPKM PTGKGRKATS NRLPPGAVNL
1260 1270 1280 1290 1300
ERSYQICQAV IQNSPNRENL KAQLRPPAAI LNQHQPTTTT APAPINPVTL
1310 1320 1330 1340 1350
NVSTVAATPM SNITTATGSM AAAVAAAPPQ NVLKQEELLV SGAVGAGALP
1360 1370 1380 1390 1400
AGLPPNVMGV GRPGVYKVIG PRMSGFPRKK YVQRKPSPTT LIRHVFSPGP
1410 1420 1430 1440 1450
GGATATAQQL QMLQQHHQST TSPVPVQNPQ QPAPEQLIHQ NGNGQYVLVH
1460 1470 1480 1490 1500
RANVGAADNQ APRASSAPPM HQNQFVTVQN PLHSINGIPM GGRGRPASVD
1510 1520 1530 1540 1550
TTAGSGNVIA PPISATDALH HHHHEMQQQQ QHQQPQPLGN VGAAANIVRR
1560 1570 1580 1590 1600
NIAAGPNIAY IDGSNTNSSA VALMEAGNNY IVTTNASPTA APSPINQQPQ
1610 1620 1630 1640 1650
SQPTGTQHQH PLLQLHQTGE NTPPGNEATA TANNCACSLN AMVICQQCGA
1660
FCHDDCIGAA KLCVACVIR
Length:1,669
Mass (Da):179,842
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF65D87398D67D321
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KFX9A0A0B4KFX9_DROME
Additional sex combs, isoform C
Asx ASX, Dmel\CG8787, FBgn0261823, xen, CG8787
1,670Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A1Z9R6A1Z9R6_DROME
Additional sex combs, isoform B
Asx ASX, Dmel\CG8787, FBgn0261823, xen, CG8787
1,560Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KFN1A0A0B4KFN1_DROME
Additional sex combs, isoform D
Asx ASX, Dmel\CG8787, FBgn0261823, xen, CG8787
1,538Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA04568 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14 – 15SQ → CE in CAA04568 (PubMed:9477319).Curated2
Sequence conflicti187K → N in CAA04568 (PubMed:9477319).Curated1
Sequence conflicti1253S → T in CAA04568 (PubMed:9477319).Curated1
Sequence conflicti1520Missing in CAA04568 (PubMed:9477319).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ001164 mRNA Translation: CAA04568.1 Frameshift.
AE013599 Genomic DNA Translation: AAF58239.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T13748

NCBI Reference Sequences

More...
RefSeqi
NP_725398.1, NM_166057.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087493; FBpp0086622; FBgn0261823

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36612

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8787

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001164 mRNA Translation: CAA04568.1 Frameshift.
AE013599 Genomic DNA Translation: AAF58239.1
PIRiT13748
RefSeqiNP_725398.1, NM_166057.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6CGAX-ray3.50B/D207-340[»]
6HGCX-ray3.02C209-318[»]
SMRiQ9V727
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi62360, 19 interactors
DIPiDIP-22881N
IntActiQ9V727, 10 interactors
STRINGi7227.FBpp0305149

Proteomic databases

PaxDbiQ9V727
PRIDEiQ9V727

Genome annotation databases

EnsemblMetazoaiFBtr0087493; FBpp0086622; FBgn0261823
GeneIDi36612
KEGGidme:Dmel_CG8787

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36612
FlyBaseiFBgn0261823 Asx

Phylogenomic databases

eggNOGiENOG410IIF3 Eukaryota
ENOG4111F3G LUCA
GeneTreeiENSGT00520000055578
InParanoidiQ9V727
KOiK11471
OMAiFADTIDH
OrthoDBi552046at2759
PhylomeDBiQ9V727

Enzyme and pathway databases

ReactomeiR-DME-5689603 UCH proteinases

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
36612

Protein Ontology

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PROi
PR:Q9V727

Gene expression databases

BgeeiFBgn0261823 Expressed in 30 organ(s), highest expression level in female gonad
ExpressionAtlasiQ9V727 baseline and differential
GenevisibleiQ9V727 DM

Family and domain databases

InterProiView protein in InterPro
IPR026905 ASX-like_PHD
IPR024811 ASX/ASX-like
IPR028020 ASXH
IPR024814 Polycomb_ASX
PANTHERiPTHR13578 PTHR13578, 1 hit
PTHR13578:SF20 PTHR13578:SF20, 1 hit
PfamiView protein in Pfam
PF13919 ASXH, 1 hit
PF13922 PHD_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASX_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9V727
Secondary accession number(s): O76930
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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