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Entry version 165 (16 Oct 2019)
Sequence version 2 (01 Oct 2002)
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Protein
Submitted name:

Numb-associated kinase, isoform A

Gene

Nak

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Numb-associated kinase, isoform AImported
Submitted name:
Numb-associated kinase, isoform DImported (EC:2.7.11.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NakImported
Synonyms:Dmel\CG10637Imported, nakImported
ORF Names:CG10637Imported, Dmel_CG10637Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0015772 Nak

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VJ30

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0015772 Expressed in 41 organ(s), highest expression level in oviduct (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VJ30 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VJ30, 144 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080729

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VJ30

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 316Protein kinaseInterPro annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31DisorderedSequence analysisAdd BLAST31
Regioni369 – 412DisorderedSequence analysisAdd BLAST44
Regioni489 – 509DisorderedSequence analysisAdd BLAST21
Regioni785 – 818DisorderedSequence analysisAdd BLAST34
Regioni888 – 929DisorderedSequence analysisAdd BLAST42
Regioni977 – 999DisorderedSequence analysisAdd BLAST23
Regioni1011 – 1035DisorderedSequence analysisAdd BLAST25
Regioni1063 – 1086DisorderedSequence analysisAdd BLAST24
Regioni1218 – 1238DisorderedSequence analysisAdd BLAST21
Regioni1382 – 1431DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 31PolarSequence analysisAdd BLAST17
Compositional biasi369 – 383PolarSequence analysisAdd BLAST15
Compositional biasi393 – 407Pro-richSequence analysisAdd BLAST15
Compositional biasi902 – 921PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1382 – 1397PolarSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1989 Eukaryota
ENOG410Y515 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170379

Identification of Orthologs from Complete Genome Data

More...
OMAi
QDQDENR

Database of Orthologous Groups

More...
OrthoDBi
831026at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9VJ30-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKILSKFER NENSRLENPP NSSSSSSSNE KNSFVGKVFT VGRVTVTVED
60 70 80 90 100
VLAEGGFAMV FLARGNGGGS SSATKYALKR MYVNNEHDLN VAKREIQIAS
110 120 130 140 150
NLSGHKNIIG YVDSSITPTG NGVCEVLLLM PYCKHHMLAM MNARLHVGFT
160 170 180 190 200
EPEVLNIFCD IAEAVSRLHY CQTPIIHRDL KVENILQTDA GNFVLCDFGS
210 220 230 240 250
ATAKTLNPQQ HGVTVVQEEI QKYTTLSYRA PEMIDLYGGK SITTKADIWA
260 270 280 290 300
LGCMLYKLCF FSLPFGESTL AIQNGQFSIP DSSKYSKGMH QLIKYMLEPD
310 320 330 340 350
MEKRPNIWQV CEVAFRLAGK DNPVQNLHKT PIPNFDLLVV PPFESEAKRI
360 370 380 390 400
SAAASKAAKA QNVSVVEAGT SVAPRSRPKG SSSVHGGNPL GLGLPPSPSP
410 420 430 440 450
RQNITSPQPQ PQPVVEQFQA NFPAMPPAVP PPPQAVTPAA PAASKLFESS
460 470 480 490 500
GYPDPFNEPA AAVIPTEFLP AAEEPNKEEV PQDLNVIAGT PTKSMLTPPK
510 520 530 540 550
PSGGGGHRRN VSDTSAFNKT FANETSQFLA PFNNNLAAMG DGQQTLASAA
560 570 580 590 600
SNPGIYASST ANSAAVSISE LMKPGQTAVE KRVEAWNPFE EEQPFSQMTE
610 620 630 640 650
DHIFEAEFDK IRQRGSQGSI TAKSASTTST LTPTEQIPSA VVAPVTAAPG
660 670 680 690 700
AVPPPPIAAA VSPYPSQVSE DPFGSAPFSL PPGLREKASS LRKTGAKFIG
710 720 730 740 750
VSSGGTGGGV ATPIGLVAGG ANTATSSNSS KWMLSPTLEV SSEEKTSLIS
760 770 780 790 800
KLKTDSECGI PGAVGGAGEG VSGYVKLPVE DRNKYEKLRS KDQPTSDDSD
810 820 830 840 850
SEASEFFQQD SDEGGGGIFR QMQMVTSNLP ETIHKIQQVA YHKVDKTAHL
860 870 880 890 900
PIVKKLRDKT KKPTTAAHQA AQQLNLMAAA VAAQAEEAAK AAESDGDSIG
910 920 930 940 950
SASDLRAEDD DLFDENPRQT QAKQRRPLPT EMDGISESVK TCSSSAYHAE
960 970 980 990 1000
CESVTTHEDD VRSRVVVKVR MRKKDRALVT ATGDPSAPSE ELSPTSSDLL
1010 1020 1030 1040 1050
HKFGDRPLLL DDELDYGSGE SKSSTESPVA PILPTNPDVQ ESEEDVFALA
1060 1070 1080 1090 1100
PFKLPVGVPL KRKTKPKAKP KPSEPEMWTS TPVKSAAVGD PSTNFASFPA
1110 1120 1130 1140 1150
QLTPTNNVGN SAQLDEFNEP IFNPFQENAQ NTQSGETNQC DLFGLEPFPQ
1160 1170 1180 1190 1200
VIRTIEQNPQ HHQIHQFPSH NNNNNVIKVP ASVSVALPAS VPVSVSVNSS
1210 1220 1230 1240 1250
APQLVTINHS IIINKTPEPP MNYNNNNNNQ TAKSSGTSSV YVNVPSFSSM
1260 1270 1280 1290 1300
STSSCSINQP QSSPAAVIPV QAPLPVPVPA PVSVPAVPVP IPAVVTHLRP
1310 1320 1330 1340 1350
LLPIADNAYV QISQDRCSDF TPDDEEEPVV LRDADVVADG IGIPTPAKPK
1360 1370 1380 1390 1400
KEKSNLAVRV LPGKLTQKVK GHSYKKVSAA ALGSTSSLSS GSKQKHQRLQ
1410 1420 1430 1440 1450
YQSHDDDDDE QDQDENRGAG GGRNFQSNTI QNSAKTGFSN MSFEDFPSDQ
1460 1470 1480
EMDRLSRTIP FEVVRNEKML LEAEKKFGSL KRRNNLFS
Length:1,488
Mass (Da):159,669
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9AA1497C2AC3D392
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7KT38Q7KT38_DROME
Numb-associated kinase, isoform C
Nak Dmel\CG10637, nak, CG10637, Dmel_CG10637
698Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2J946X2J946_DROME
Numb-associated kinase, isoform E
Nak Dmel\CG10637, nak, CG10637, Dmel_CG10637
708Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53727.2
AE014134 Genomic DNA Translation: AAN11019.2

NCBI Reference Sequences

More...
RefSeqi
NP_477165.1, NM_057817.4
NP_477166.2, NM_057818.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081187; FBpp0080729; FBgn0015772
FBtr0340325; FBpp0309286; FBgn0015772

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35154

UCSC genome browser

More...
UCSCi
CG10637-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53727.2
AE014134 Genomic DNA Translation: AAN11019.2
RefSeqiNP_477165.1, NM_057817.4
NP_477166.2, NM_057818.4

3D structure databases

SMRiQ9VJ30
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9VJ30, 144 interactors
STRINGi7227.FBpp0080729

Proteomic databases

PRIDEiQ9VJ30

Genome annotation databases

EnsemblMetazoaiFBtr0081187; FBpp0080729; FBgn0015772
FBtr0340325; FBpp0309286; FBgn0015772
GeneIDi35154
UCSCiCG10637-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
35154
FlyBaseiFBgn0015772 Nak

Phylogenomic databases

eggNOGiKOG1989 Eukaryota
ENOG410Y515 LUCA
GeneTreeiENSGT00940000170379
OMAiQDQDENR
OrthoDBi831026at2759

Enzyme and pathway databases

ReactomeiR-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Atpalpha fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35154

Gene expression databases

BgeeiFBgn0015772 Expressed in 41 organ(s), highest expression level in oviduct (Drosophila)
ExpressionAtlasiQ9VJ30 differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VJ30_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VJ30
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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