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Entry version 142 (16 Oct 2019)
Sequence version 2 (01 Oct 2002)
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Protein

AF4/FMR2 family member 4

Gene

lilli

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi851 – 863A.T hookSequence analysisAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: FlyBase
  • DNA-binding transcription factor activity Source: UniProtKB
  • double-stranded DNA binding Source: GO_Central
  • RNA polymerase II-specific DNA-binding transcription factor binding Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Pair-rule protein
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-112382 Formation of RNA Pol II elongation complex
R-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-75955 RNA Polymerase II Transcription Elongation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AF4/FMR2 family member 41 Publication
Alternative name(s):
Protein lilliputian1 Publication
Suppressor of Raf at 2A1 Publication
Suppressor of sina 2-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lilliImported
Synonyms:l(2)006321 Publication, SS2-11 Publication, Su(Raf)2A1 Publication
ORF Names:CG8817
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0041111 lilli

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryos lacking maternal lilli show specific defects in the establishment of a functional cytoskeleton during cellularization, and exhibit a pair-rule segmentation phenotype. Adults lacking lilli exhibit reduction in cell and organ size and partial suppression of the increased growth associated with loss of PTEN function.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003946751 – 1673AF4/FMR2 family member 4Add BLAST1673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei420Phosphothreonine1 Publication1
Modified residuei450Phosphoserine1 Publication1
Modified residuei452Phosphoserine1 Publication1
Modified residuei821Phosphoserine1 Publication1
Modified residuei822Phosphoserine1 Publication1
Modified residuei871Phosphoserine1 Publication1
Modified residuei873Phosphoserine1 Publication1
Modified residuei1362Phosphoserine1 Publication1
Modified residuei1364Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VQI9

PRoteomics IDEntifications database

More...
PRIDEi
Q9VQI9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VQI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0041111 Expressed in 22 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VQI9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VQI9 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the super elongation complex (SEC), at least composed of Ell, Cdk9, cyclin-T (CycT), lilli and ear.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
59717, 38 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VQI9, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0077318

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VQI9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 48Gln-richSequence analysisAdd BLAST46
Compositional biasi463 – 484Ser-richSequence analysisAdd BLAST22
Compositional biasi489 – 525Gln-richSequence analysisAdd BLAST37
Compositional biasi720 – 743Ser-richSequence analysisAdd BLAST24
Compositional biasi941 – 1060Ser-richSequence analysisAdd BLAST120

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGJB Eukaryota
ENOG410XRXU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VQI9

KEGG Orthology (KO)

More...
KOi
K15194

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VQI9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797 TF_AF4/FMR2

The PANTHER Classification System

More...
PANTHERi
PTHR10528 PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05110 AF-4, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00354 HMGI_Y, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A1 Publication (identifier: Q9VQI9-1) [UniParc]FASTAAdd to basket
Also known as: B1 Publication, C1 Publication, G1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQQQQQQMQ QQQQHHTSSI NNNNSSSIVL LQQQQPQQQQ QQLDQLQQYN
60 70 80 90 100
NNLYSQNYNM EEYERRKRRE REKIERQQGI QIDDRETSLF GEPRRLTEGD
110 120 130 140 150
AEITAALGEF FEAREYINNQ TVGISRSAPG AGNPRLQPNL APQAKSLGHS
160 170 180 190 200
PSSASSAAGP TAASATTSLP GQQQHYQQQQ RPPTYVKQAD NKPPYNGRGG
210 220 230 240 250
YPGQPMKNDI PSSSGMAPPR GPPRTSSSNS NSSSVTNNAS SGGVPASTPL
260 270 280 290 300
GPPLSTQMPN GREKSFLGPP APALHNGTGG RFVPPAASKR PGVGQQPPPP
310 320 330 340 350
EKDVNKIISD IANIFTVQPL TLIAATPHAP TRENYNLLAP NRQKYAMDIP
360 370 380 390 400
SSPPSAEPSS LMTPLFAPIT SPIAPLVTTP PQASQMPLGG ATSGTILAGE
410 420 430 440 450
ALAPLHQLPP TMPKAASGVT SPGPVKPLKT EKNHSLEKQD SCLENDLELS
460 470 480 490 500
ESEDEQRKKE GRSGGNSSNS SESDSSESGS ESSSKNDLQH HPNHQQHHHQ
510 520 530 540 550
LQQQQQQQQA TMQQQQVLQQ QHRSQPLTSN GAQNKKFRHE IIARGSNTIT
560 570 580 590 600
GLLSSSGFGS GGNVGPAGVN SNAVVGTGSG SGGTLSSGGS SSNKTPSPTE
610 620 630 640 650
SNKWNLSRFF HKPANQTNSE SVSPGNVSMK VPGILPGGAQ IIPESIDVTT
660 670 680 690 700
AIVKNEKNDM AMEEGEEEDD DEEQQLRYGG GLSVTPVAVK KEAIDAVSEM
710 720 730 740 750
ALGAIPKTQI KRESAETLLS ARLSDSGTSA SGSSSSSSSS SDSAMGGEVV
760 770 780 790 800
PMPGPGETLQ LPGVPAAITT VMRVQPTQSQ KAPPSNSVTL TPILPLPTSP
810 820 830 840 850
KQRQKKPRKK KAITSAPILD SSDDDEPPPK HPGLDHTAVS VQTQPATDTV
860 870 880 890 900
KKGRGRPRKQ QQSGGSGNLS SASAGSSSQT KGPTLTAAKK PLAKTPLAMS
910 920 930 940 950
RARKREHSSQ SSSNGNTPTK KVATPQLVAA PLKPTSNTAG SSSSDEDSSS
960 970 980 990 1000
SAESSSKSSS SSSSSDDTET QNTNCRIVKL NKTGAVQKKA LLGSGSSSPS
1010 1020 1030 1040 1050
SSGSEAEDQT TRSQVGSGQA LAQQLPPYKQ LPISQHSQHL SSSDCSSSSG
1060 1070 1080 1090 1100
GCTAVCSSSS GEEDEGRREK ERERKPKSDK NKINTLTRIF NPKEGGAKKQ
1110 1120 1130 1140 1150
GQVVIVDLQE EQQQGKLDAA AQPSAPQAPP AAPAAIMAKP RMTPTQQQQL
1160 1170 1180 1190 1200
GAGLASPART TTPHLTSLIC KIDLSKLSRE RIMRLKKLTP AQQNGHLTPK
1210 1220 1230 1240 1250
DQATNAVHVP NGYAGDTNPA AKVKHEHPVK PEPELDAGYE AKFKPGNVKQ
1260 1270 1280 1290 1300
EFQLKQERDR DRERERERER ERERDREREQ PPGRRRKRSS SSSSSPYKEK
1310 1320 1330 1340 1350
KRKKEKADQL QMGKELLPVP VLLPSNNHER MPNHDRLSYD KLQLLHEDAA
1360 1370 1380 1390 1400
AVIGDVSAPN GSPTKKLLAM SPLPPPPTVT VAPATCNEAV QTTPPSATAT
1410 1420 1430 1440 1450
SAIAPPVPAT RLIYRSYFDR DVEHPSDDPR KNNQFLQEAI NRKHAADLER
1460 1470 1480 1490 1500
DSFNQVTLYL EAVVYFLLTA DAMERCSSEQ ATNTMYKDTL SLIKFISTKF
1510 1520 1530 1540 1550
RPYQQQSTTN IQHETHNKVA ILSLRCQSLI SLKLYKLRRK DCRAIINSLT
1560 1570 1580 1590 1600
DFFRVGRGDI ANGNTPSSIS PSNSVGSQGS GSNTPPGRIV PPDIHNMLCK
1610 1620 1630 1640 1650
QNEFLSYLNS AHELWDQADR LVRTGNHIDF IRELDHENGP LTLHSTMHEV
1660 1670
FRYVQAGLKT LRDAVSHPTH QSQ
Length:1,673
Mass (Da):180,089
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D32A4E81C55B752
GO
Isoform D1 Publication (identifier: Q9VQI9-2) [UniParc]FASTAAdd to basket
Also known as: E1 Publication, F1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,614
Mass (Da):173,034
Checksum:iC8B04AF6642F9B4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PCF6M9PCF6_DROME
Lilliputian, isoform H
lilli 154454_at, 189Y, AFF4, BcDNA:GM02019, BEST:GH09955
1,614Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W5PXG3A0A1W5PXG3_DROME
Lilliputian, isoform I
lilli 154454_at, 189Y, AFF4, BcDNA:GM02019, BEST:GH09955
1,626Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL28786 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence ACX54921 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti235V → A in ACX54921 (Ref. 5) Curated1
Sequence conflicti254L → M in ACX54921 (Ref. 5) Curated1
Sequence conflicti614A → T in ACX54921 (Ref. 5) Curated1
Sequence conflicti1201D → I in ACX54921 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0392941 – 59Missing in isoform D. 2 PublicationsAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF293971 mRNA Translation: AAG53639.1
AF289034 mRNA Translation: AAK18163.1
AE014134 Genomic DNA Translation: AAF51180.2
AE014134 Genomic DNA Translation: AAN10399.1
AE014134 Genomic DNA Translation: AAN10400.1
AE014134 Genomic DNA Translation: ACL82979.1
AE014134 Genomic DNA Translation: ACL82980.1
AE014134 Genomic DNA Translation: ACL82981.1
AE014134 Genomic DNA Translation: ACL82982.1
BT100013 mRNA Translation: ACX54921.1 Frameshift.
AY061238 mRNA Translation: AAL28786.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001137772.1, NM_001144300.2 [Q9VQI9-2]
NP_001137773.1, NM_001144301.1 [Q9VQI9-2]
NP_001137774.1, NM_001144302.2 [Q9VQI9-2]
NP_001137775.1, NM_001144303.1 [Q9VQI9-1]
NP_001259973.1, NM_001273044.1 [Q9VQI9-2]
NP_523464.1, NM_078740.3 [Q9VQI9-1]
NP_722863.1, NM_164516.2 [Q9VQI9-1]
NP_722864.1, NM_164517.1 [Q9VQI9-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077632; FBpp0077317; FBgn0041111 [Q9VQI9-1]
FBtr0077633; FBpp0077318; FBgn0041111 [Q9VQI9-1]
FBtr0077634; FBpp0077319; FBgn0041111 [Q9VQI9-1]
FBtr0290038; FBpp0288477; FBgn0041111 [Q9VQI9-2]
FBtr0290039; FBpp0288478; FBgn0041111 [Q9VQI9-2]
FBtr0290040; FBpp0288479; FBgn0041111 [Q9VQI9-2]
FBtr0290041; FBpp0288480; FBgn0041111 [Q9VQI9-1]
FBtr0332458; FBpp0304731; FBgn0041111 [Q9VQI9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
33496

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8817

UCSC genome browser

More...
UCSCi
CG8817-RA d. melanogaster [Q9VQI9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293971 mRNA Translation: AAG53639.1
AF289034 mRNA Translation: AAK18163.1
AE014134 Genomic DNA Translation: AAF51180.2
AE014134 Genomic DNA Translation: AAN10399.1
AE014134 Genomic DNA Translation: AAN10400.1
AE014134 Genomic DNA Translation: ACL82979.1
AE014134 Genomic DNA Translation: ACL82980.1
AE014134 Genomic DNA Translation: ACL82981.1
AE014134 Genomic DNA Translation: ACL82982.1
BT100013 mRNA Translation: ACX54921.1 Frameshift.
AY061238 mRNA Translation: AAL28786.1 Different initiation.
RefSeqiNP_001137772.1, NM_001144300.2 [Q9VQI9-2]
NP_001137773.1, NM_001144301.1 [Q9VQI9-2]
NP_001137774.1, NM_001144302.2 [Q9VQI9-2]
NP_001137775.1, NM_001144303.1 [Q9VQI9-1]
NP_001259973.1, NM_001273044.1 [Q9VQI9-2]
NP_523464.1, NM_078740.3 [Q9VQI9-1]
NP_722863.1, NM_164516.2 [Q9VQI9-1]
NP_722864.1, NM_164517.1 [Q9VQI9-1]

3D structure databases

SMRiQ9VQI9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi59717, 38 interactors
IntActiQ9VQI9, 5 interactors
STRINGi7227.FBpp0077318

PTM databases

iPTMnetiQ9VQI9

Proteomic databases

PaxDbiQ9VQI9
PRIDEiQ9VQI9

Genome annotation databases

EnsemblMetazoaiFBtr0077632; FBpp0077317; FBgn0041111 [Q9VQI9-1]
FBtr0077633; FBpp0077318; FBgn0041111 [Q9VQI9-1]
FBtr0077634; FBpp0077319; FBgn0041111 [Q9VQI9-1]
FBtr0290038; FBpp0288477; FBgn0041111 [Q9VQI9-2]
FBtr0290039; FBpp0288478; FBgn0041111 [Q9VQI9-2]
FBtr0290040; FBpp0288479; FBgn0041111 [Q9VQI9-2]
FBtr0290041; FBpp0288480; FBgn0041111 [Q9VQI9-1]
FBtr0332458; FBpp0304731; FBgn0041111 [Q9VQI9-2]
GeneIDi33496
KEGGidme:Dmel_CG8817
UCSCiCG8817-RA d. melanogaster [Q9VQI9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33496
FlyBaseiFBgn0041111 lilli

Phylogenomic databases

eggNOGiENOG410IGJB Eukaryota
ENOG410XRXU LUCA
GeneTreeiENSGT00950000182974
InParanoidiQ9VQI9
KOiK15194
PhylomeDBiQ9VQI9

Enzyme and pathway databases

ReactomeiR-DME-112382 Formation of RNA Pol II elongation complex
R-DME-674695 RNA Polymerase II Pre-transcription Events
R-DME-75955 RNA Polymerase II Transcription Elongation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
lilli fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
33496

Protein Ontology

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PROi
PR:Q9VQI9

Gene expression databases

BgeeiFBgn0041111 Expressed in 22 organ(s), highest expression level in testis
ExpressionAtlasiQ9VQI9 baseline and differential
GenevisibleiQ9VQI9 DM

Family and domain databases

InterProiView protein in InterPro
IPR007797 TF_AF4/FMR2
PANTHERiPTHR10528 PTHR10528, 1 hit
PfamiView protein in Pfam
PF05110 AF-4, 1 hit
PROSITEiView protein in PROSITE
PS00354 HMGI_Y, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAFF4_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VQI9
Secondary accession number(s): B7YZZ6
, C9QPD1, Q95RP2, Q9BH66
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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