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Entry version 148 (16 Oct 2019)
Sequence version 3 (04 Apr 2006)
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Protein

Probable E3 ubiquitin-protein ligase HERC2

Gene

HERC2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4850Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HERC2 (EC:2.3.2.26)
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 2
HECT-type E3 ubiquitin transferase HERC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HERC2
ORF Names:CG11734
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0031107 HERC2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002297411 – 4912Probable E3 ubiquitin-protein ligase HERC2Add BLAST4912

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1776Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VR91

PRoteomics IDEntifications database

More...
PRIDEi
Q9VR91

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VR91

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031107 Expressed in 26 organ(s), highest expression level in embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VR91 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
59326, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VR91, 20 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0290558

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VR91

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati634 – 685RCC1 1Sequence analysisAdd BLAST52
Repeati686 – 739RCC1 2Sequence analysisAdd BLAST54
Repeati741 – 789RCC1 3Sequence analysisAdd BLAST49
Repeati791 – 843RCC1 4Sequence analysisAdd BLAST53
Repeati844 – 897RCC1 5Sequence analysisAdd BLAST54
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1917 – 1990MIB/HERC2PROSITE-ProRule annotationAdd BLAST74
Domaini2511 – 2557UBAPROSITE-ProRule annotationAdd BLAST47
Domaini2780 – 2958DOCPROSITE-ProRule annotationAdd BLAST179
Repeati2985 – 3036RCC1 6Sequence analysisAdd BLAST52
Repeati3037 – 3090RCC1 7Sequence analysisAdd BLAST54
Repeati3091 – 3142RCC1 8Sequence analysisAdd BLAST52
Repeati3144 – 3194RCC1 9Sequence analysisAdd BLAST51
Repeati3197 – 3248RCC1 10Sequence analysisAdd BLAST52
Repeati3250 – 3300RCC1 11Sequence analysisAdd BLAST51
Repeati3302 – 3352RCC1 12Sequence analysisAdd BLAST51
Repeati4049 – 4099RCC1 13Sequence analysisAdd BLAST51
Repeati4101 – 4153RCC1 14Sequence analysisAdd BLAST53
Repeati4155 – 4205RCC1 15Sequence analysisAdd BLAST51
Repeati4207 – 4259RCC1 16Sequence analysisAdd BLAST53
Repeati4261 – 4311RCC1 17Sequence analysisAdd BLAST51
Repeati4313 – 4363RCC1 18Sequence analysisAdd BLAST51
Repeati4365 – 4415RCC1 19Sequence analysisAdd BLAST51
Domaini4547 – 4882HECTPROSITE-ProRule annotationAdd BLAST336

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 60Gly-richSequence analysisAdd BLAST53
Compositional biasi137 – 163Cys-richSequence analysisAdd BLAST27

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0939 Eukaryota
KOG1426 Eukaryota
COG5021 LUCA
COG5184 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154975

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VR91

KEGG Orthology (KO)

More...
KOi
K10595

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMEMGFT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VR91

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08664 APC10-HERC2, 1 hit
cd00078 HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.30, 3 hits
2.30.30.30, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR021097 CPH_domain
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR008979 Galactose-bd-like_sf
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR037976 HERC2_APC10
IPR010606 Mib_Herc2
IPR037252 Mib_Herc2_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR014722 Rib_L2_dom2
IPR015940 UBA
IPR009060 UBA-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11515 Cul7, 1 hit
PF00173 Cyt-b5, 1 hit
PF00632 HECT, 1 hit
PF06701 MIB_HERC2, 1 hit
PF00415 RCC1, 15 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00633 RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01337 APC10, 1 hit
SM00119 HECTc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF159034 SSF159034, 1 hit
SSF46934 SSF46934, 1 hit
SSF49785 SSF49785, 1 hit
SSF50985 SSF50985, 3 hits
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51284 DOC, 1 hit
PS50237 HECT, 1 hit
PS51416 MIB_HERC2, 1 hit
PS00626 RCC1_2, 1 hit
PS50012 RCC1_3, 18 hits
PS50030 UBA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B1 Publication (identifier: Q9VR91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFNRQASGGA GSSGQGAGSS QTASAAPVSA GVGVGGGGGA SGAAAGAGSA
60 70 80 90 100
AGSGSGSGSG SAAPPSHSPD LYLRPLPFLD AKWLRADLIA SLRNAADGAV
110 120 130 140 150
LWNHLIQDCE LVSSPTAPLL NARGQLSYLG DDGKHYCGAQ QLKCSCCQPE
160 170 180 190 200
YCGPLSACNC DGCRPLDSDT AIKKLTTQAA AQQAAHLSQA TDMVLSGWLW
210 220 230 240 250
SQPPSQQARL DCQRSMISEL QELALRAAGN CLSAQHLRQQ LFIYERYFVA
260 270 280 290 300
LKRERERERK STTSAQAVAS VTTANTTIAA TTANAAVESQ PAEQQAEHGA
310 320 330 340 350
LGLARVATHA ALNFSFAFLR RAWRSGEDTE MCSELLSEAL ASLQELPEAT
360 370 380 390 400
LFEAAVVSSL WLEVMERSIK FLRLVALGDP MGNRCTAPLN DRHTALCLLL
410 420 430 440 450
ELGVQKGTLA ATLECVVLLL LLWEKDRAGN DNRDMPRKTG APLQRILLRY
460 470 480 490 500
QKIGATAKGG GIAGGEPAPV ASATETFLRF LSLPKSSAAI VDLRRAAVVI
510 520 530 540 550
ISHLDRMVQP LMPRCLLRGG QATAASSSSA PQQRIYALGW PSLSKDQQGF
560 570 580 590 600
SAEPTLSWSG ESAGVPTLSC RFQIKQVACC ETQMLILSQE GKLYTWRLAK
610 620 630 640 650
PEAEPLPMEE VAHDVFISIA GHCEGRHFLA IDSNHNAYSW GTGEDHRLGH
660 670 680 690 700
GDTHARAVPT KIAALEQHCV QSVYCGCSYS AAITCGGNLL TWGRGTYARL
710 720 730 740 750
GHGNSDDRSL PTLVVALSDH MVVDVALGSG DAHSLALTSE GLVFAWGDGD
760 770 780 790 800
YGKLGNGNCN GSLQPILVES LPRVQRVFAG SQFSVALSSE GQLYTWGKAT
810 820 830 840 850
CLGHQLVERS VQGCSVPRLV SSLQHKRIVD VAVSVAHCLA LSSSGEVFGW
860 870 880 890 900
GRNDSQQICP ASVSSEPLLR TPILVSLPTF PASGIACTSA QSLVWTQSSH
910 920 930 940 950
QGVPRRAPFV VDLGEPTFRL LDQLLGMCSS QDNRQTPNQE SECIAVACLN
960 970 980 990 1000
LFRLQLLALI ANGVEPRQVG LASGSRLLCS LKTRILGLAG GSQVLRTIQV
1010 1020 1030 1040 1050
AAQQALQDGW SVLLPTAAER AQTLTSLLPS EPGQASSAGH RFMTDLLVSS
1060 1070 1080 1090 1100
LMAEGGLESA LQHAIRLESS SCSADCGDGV HLPLLQLITR LLSNNAALSQ
1110 1120 1130 1140 1150
TRLSPTLGKQ QEKEEEEREQ QHQEPSTSPS LSLLHRFQRL LLSHIHQAQP
1160 1170 1180 1190 1200
EEETTGAEAL LLQYMHALIP ACVATLQKAH ELALQCREPG ENSFGQMVGH
1210 1220 1230 1240 1250
LGRVLQADIS DALLNELLVG LLLLKRDRPQ CLGGLRWARL FLPLLRVLDR
1260 1270 1280 1290 1300
LNRALGEGEL RDGDDMGWPG IICRGGPKGG PPPADPETHY VRRADMENLL
1310 1320 1330 1340 1350
LDGSRCIILA GYVCDLSGYN CESETLRSVL DSGLGKDLTA EMSSQVHRTA
1360 1370 1380 1390 1400
MEHILEHHKL GKYMVQASTE EKSSAPGPSR LTHFSSECAL AQLLGLVANL
1410 1420 1430 1440 1450
MCSGPALQPA ELQCRQLDKS SLLSGGLQLL QPSNPFDEEK GEARSSHSCH
1460 1470 1480 1490 1500
STAGNTPTEL PPPLPMQQQL APGRGKSQLQ LRADAFISGL AEARVSEPPV
1510 1520 1530 1540 1550
AAWLALTERY CKAHNLMWHQ EFATEHPVQE LERLLSAVLI RHQYLGGLVL
1560 1570 1580 1590 1600
NALETEVPPP RQLGEIIRLV HQAKWSVVRT RQQLNRSYKE VCAPILERLR
1610 1620 1630 1640 1650
FLLYEVRPAI SPQQRGLRRL PILQRPPRFK MLVRRLLQEL RSSRQPAKPE
1660 1670 1680 1690 1700
DLLNASIQQE QEKKPQSMPK QELEEQEEEE TLLRRLNERQ IHGEGELDPA
1710 1720 1730 1740 1750
LMQDIVDFAL QDSCDVETAR RAMYCQMQRY QLRLAGLQIV QQLLELHGLL
1760 1770 1780 1790 1800
DAAQYSLLNG FLGLHLKSTS SGGGSTGSGS SLHVLGQLNM ISAYQKARLL
1810 1820 1830 1840 1850
LAQSRVLDWA VRELRRLVNQ EQQGHARGKD STNLGTYVLL KRLPRARFLL
1860 1870 1880 1890 1900
SVFGLLAKEL GPNELGFLIN SGLLGTVLGL LAQTGGEGAT GGQVHGELSI
1910 1920 1930 1940 1950
LYEDSVLKQK SSKAQLSGPD LAKLMKIGTR IVRGADWKWG DQDGNPPGEG
1960 1970 1980 1990 2000
RIISEVGEDG WVRVEWYTGA TNSYRMGKEG QYDLQLADSA LNVASPTEPE
2010 2020 2030 2040 2050
REDVSGSEAS PTSDSHPSKL LRHCAAKLLQ ILAVGTGLHG AQLDKDALRG
2060 2070 2080 2090 2100
MTSMFRTIIY PKPSMSNISY ALGWLNLGFI RAISGDCPRL CLELSTPGWL
2110 2120 2130 2140 2150
SHYLSLLEQP AGNEAGVYRQ LHCLRLLQLI LAQWGAEEEP RMPALVHQLF
2160 2170 2180 2190 2200
ATLGRIALHC PGDASLLPTA EGKARVLLTA SHSGSVAEEL VALLRRLHTL
2210 2220 2230 2240 2250
PSWNPVINSF LAQKLCVAAE LLAEQSHSTA LDSEQVFVLG VLGAMGGHDL
2260 2270 2280 2290 2300
RPRVGLHCFH EGSHMVIASF TPKGRCLLAP GGVGSGVGFV KVQLPAVMPH
2310 2320 2330 2340 2350
LDHTVFSLSR LPMNEMLLNA WTVLLYGPAP ELRELPSSAD GRLDLALLRA
2360 2370 2380 2390 2400
QQLQMAVLHT NGVLYRHQVA LRRILKQRAP GSIYASPDEP DRSDAESQQP
2410 2420 2430 2440 2450
GEQDQQLSSG SGQEPQLLIQ CILLRATQAS PVKACYSYMD LATAALNCIQ
2460 2470 2480 2490 2500
SLATQAHQEL SEGGGVPPNG RALSSPPQPT MVHGVPVYNV ARKEQKPSEQ
2510 2520 2530 2540 2550
VEQKSKWPAA ATDAQLIGQI MEMGFTRRTV ELALKQLSLQ AEIMPTPEQI
2560 2570 2580 2590 2600
VQWILEHPDV CANTIEEDTL PLASSASSHD PEADSDNECP SSNSTTSSST
2610 2620 2630 2640 2650
SSDTVEGQPM AVSGPAPPVK FESRKDFQTA DLYALYVRGL VRPGMTVRCC
2660 2670 2680 2690 2700
RDFEEIKQGD MGTVLIVDTE GLHDLNVQVD WRNHGSTYWV CFVHIELVEA
2710 2720 2730 2740 2750
AQTHHQPRPP PIAVGARVRL RTSSLRYGML CPLRLGRSQG SSAIGVVSSV
2760 2770 2780 2790 2800
RSKQLTVDFP DQPAWQGHIN EVELVASQPT SATLPSLGDS CSQMPPSDLI
2810 2820 2830 2840 2850
EDWSRCIRSL TVSSNEAAAK HLLNGSNQPW QSCSSGPCRH WIRLELHDRI
2860 2870 2880 2890 2900
LVHSLTLKVS PEDHSHMPSL LEIRVGDCVD SLKEYTWIPV PAGASRVLLM
2910 2920 2930 2940 2950
QQVPTYYPWV EVVVKQCQNN GIQCKIHGIK FVGRRQQPDL QHILANAQFL
2960 2970 2980 2990 3000
ASEYSAGVGP GSTAGAGAVS TSHEEAAAAP EQDLPCTVMV WGLNDKEQLG
3010 3020 3030 3040 3050
GLKGSKVKVP TFSQTISRLR PIHIAGGSKS LFIVSQDGKV YACGEGTNGR
3060 3070 3080 3090 3100
LGLGVTHNVP LPHQLPVLRQ YVVKKVAVHS GGKHALALTL DGKVFSWGEG
3110 3120 3130 3140 3150
EDGKLGHGNR TTLDKPRLVE ALRAKKIRDV ACGSSHSAAI SSQGELYTWG
3160 3170 3180 3190 3200
LGEYGRLGHG DNTTQLKPKL VTALAGRRVV QVACGSRDAQ TLALTEDGAV
3210 3220 3230 3240 3250
FSWGDGDFGK LGRGGSEGSD TPHEIERLSG IGVVQIECGA QFSLALTRAG
3260 3270 3280 3290 3300
EVWTWGKGDY YRLGHGGDQH VRKPQPIGGL RGRRVIHVAV GALHCLAVTD
3310 3320 3330 3340 3350
AGQVYAWGDN DHGQQGSGNT FVNKKPALVI GLDAVFVNRV ACGSSHSIAW
3360 3370 3380 3390 3400
GLPNASSDEE KRGPVPFSST RDPLGGSSLG IYEAETMQTL KQEAKPLNQS
3410 3420 3430 3440 3450
SLSESLALET PAARQAALGH VLRAMSILQA RQLIVAALTS HSKVNFKERG
3460 3470 3480 3490 3500
AVGGEEDHLI GGPIMGAPLQ LAETIAQGGG EAPADATDAG LQEHSPEAAV
3510 3520 3530 3540 3550
DALTGGMSGG ANTLPPLSAG PLSAFQSLTG SLSMSGSLSS SALPQHKHSR
3560 3570 3580 3590 3600
MSASAMSVMA ATMTQQEEML SHISHCHGLD DFGGLLGEPE AKSLVELLKL
3610 3620 3630 3640 3650
AVCGRCGPPS TSQTIADTLI SLGAGTPAVA AMLLETCITE LEDLCTSRHC
3660 3670 3680 3690 3700
LGKLPKPVMQ ESSHPYVDNV NVTGVVRIPG AEMLRLEFDS QCSTEKRNDP
3710 3720 3730 3740 3750
LVIMDGTGRV LAMRSGREFA HWAPEIRVLG DELRWKFSSD SSVNGWGWRF
3760 3770 3780 3790 3800
WVHAIMPAAT LGESGSDRAV LSQPSMALVM SLLDSRLAPR QPSVLLRLAS
3810 3820 3830 3840 3850
ALAACSQLGA LTTAQRIWSL RKLHAVLLLE QAPRPQDPSL STLLQPLIPE
3860 3870 3880 3890 3900
LLRQYEYEEP QVRGGIHLMH SDYFKTLAAL ACDMQLDAAL PATSSSSSSS
3910 3920 3930 3940 3950
AAPGAISSTG DVHKWAWFKR YCIAVRVAQS LIRRTELPRA FCLEVRKKFA
3960 3970 3980 3990 4000
EMLPSSSSNS NANPGCQSPG ASMLNSTTSL SSSTVSNVSP PPGITGEQPD
4010 4020 4030 4040 4050
LHCHAHQLES TSTLLHEDHT LFQAPHDAQL LQWLNRRPDD WALSWGGAST
4060 4070 4080 4090 4100
IYGWGHNHRG QLGGLEGSRI KTPTPCEALS LLRPVQLAGG EQSLFAVTPD
4110 4120 4130 4140 4150
GKLFATGYGS GGRLGVGGSD SWAIPTLLGS LQHVFVKKVA VNSGGKHCLA
4160 4170 4180 4190 4200
LTTEGEVYAW GEGEDGKLGH GNRMSYDRPK LVEHLNGMSV ADIACGSAHS
4210 4220 4230 4240 4250
AAITASGHVL TWGKGRYGRL GHGDSEDQLR PKLVEALLGY RAIDIACGSG
4260 4270 4280 4290 4300
DAQTLCITDD DNVWSWGDGD YGKLGRGGSD GCKLPYKIES LAGLGVVKVE
4310 4320 4330 4340 4350
CGSQFSVALT KSGAVYTWGK GDFHRLGHGS VDHVRRPKKV AALQGKKIIS
4360 4370 4380 4390 4400
IATGSLHCVA CSDSGEVYTW GDNDEGQLGD GTVTAIQRPR LVAALQGKHI
4410 4420 4430 4440 4450
VKVTCGSAHT LALSTSQLSE RLRPLPNPPL EYDLVRDLAP EALHARLILL
4460 4470 4480 4490 4500
HHFSELVCPC LAMLPISGDL SLGALKDVLV YNIKEAAFRK VIQTTMVRDK
4510 4520 4530 4540 4550
QHGPVIELNR IQVKRSRNRC NGLAGIDGMK SVFGQMVQKL PLLTQEALAL
4560 4570 4580 4590 4600
PHRVWKVKFV GESVDDCGGG YSESIAEMCD ELQNGSVPLL INTPNGRGEA
4610 4620 4630 4640 4650
GANRDCFLLD PTLSSVLQMN MFRFLGVLMG IAVRTGSPLS INLAEPVWRQ
4660 4670 4680 4690 4700
LTGEVLRPTD LTEVDRDYVA GLLCIRNMDD DPKLFTALEL PFSTSSARGH
4710 4720 4730 4740 4750
EVPLSTRYTH ISPRNRAEYV RLALGFRLHE FDEQVKAVRD GMSKVIPVPL
4760 4770 4780 4790 4800
LSLFSAAELQ AMVCGSPDIP LGLLKSVATY KGFDPSSALV TWFWEVMEEF
4810 4820 4830 4840 4850
TNQERSLFLR FVWGRTRLPR TIADFRGRDF VLQVLEKNPP DHFLPESYTC
4860 4870 4880 4890 4900
FFLLKMPRYS CKAVLLEKLK YAIHFCKSID TDEYARVAMG EPTEATGSED
4910
NSDLESVASH EG
Length:4,912
Mass (Da):529,997
Last modified:April 4, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39F45CEBEB6350DF
GO
Isoform A1 Publication (identifier: Q9VR91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     635-636: HN → RK
     637-4912: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:636
Mass (Da):67,367
Checksum:i80E4E5C3B295B8F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4388R → W in AAF61856 (PubMed:10720573).Curated1
Sequence conflicti4393A → T in AAF61856 (PubMed:10720573).Curated1
Sequence conflicti4481Y → C in AAF61856 (PubMed:10720573).Curated1
Sequence conflicti4575I → T in AAF61856 (PubMed:10720573).Curated1
Sequence conflicti4652T → M in AAF61856 (PubMed:10720573).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051976635 – 636HN → RK in isoform A. 1 Publication2
Alternative sequenceiVSP_051977637 – 4912Missing in isoform A. 1 PublicationAdd BLAST4276

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF50913.3
AY113293 mRNA Translation: AAM29298.1
AF189221 mRNA Translation: AAF61856.1

NCBI Reference Sequences

More...
RefSeqi
NP_608388.2, NM_134544.3 [Q9VR91-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0301344; FBpp0290558; FBgn0031107 [Q9VR91-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33035

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG11734

UCSC genome browser

More...
UCSCi
CG11734-RB d. melanogaster [Q9VR91-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF50913.3
AY113293 mRNA Translation: AAM29298.1
AF189221 mRNA Translation: AAF61856.1
RefSeqiNP_608388.2, NM_134544.3 [Q9VR91-1]

3D structure databases

SMRiQ9VR91
ModBaseiSearch...

Protein-protein interaction databases

BioGridi59326, 5 interactors
IntActiQ9VR91, 20 interactors
STRINGi7227.FBpp0290558

PTM databases

iPTMnetiQ9VR91

Proteomic databases

PaxDbiQ9VR91
PRIDEiQ9VR91

Genome annotation databases

EnsemblMetazoaiFBtr0301344; FBpp0290558; FBgn0031107 [Q9VR91-1]
GeneIDi33035
KEGGidme:Dmel_CG11734
UCSCiCG11734-RB d. melanogaster [Q9VR91-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8924
FlyBaseiFBgn0031107 HERC2

Phylogenomic databases

eggNOGiKOG0939 Eukaryota
KOG1426 Eukaryota
COG5021 LUCA
COG5184 LUCA
GeneTreeiENSGT00940000154975
InParanoidiQ9VR91
KOiK10595
OMAiIMEMGFT
PhylomeDBiQ9VR91

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33035

Protein Ontology

More...
PROi
PR:Q9VR91

Gene expression databases

BgeeiFBgn0031107 Expressed in 26 organ(s), highest expression level in embryo
GenevisibleiQ9VR91 DM

Family and domain databases

CDDicd08664 APC10-HERC2, 1 hit
cd00078 HECTc, 1 hit
Gene3Di2.130.10.30, 3 hits
2.30.30.30, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR021097 CPH_domain
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR008979 Galactose-bd-like_sf
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR037976 HERC2_APC10
IPR010606 Mib_Herc2
IPR037252 Mib_Herc2_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR014722 Rib_L2_dom2
IPR015940 UBA
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF11515 Cul7, 1 hit
PF00173 Cyt-b5, 1 hit
PF00632 HECT, 1 hit
PF06701 MIB_HERC2, 1 hit
PF00415 RCC1, 15 hits
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM01337 APC10, 1 hit
SM00119 HECTc, 1 hit
SUPFAMiSSF159034 SSF159034, 1 hit
SSF46934 SSF46934, 1 hit
SSF49785 SSF49785, 1 hit
SSF50985 SSF50985, 3 hits
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS51284 DOC, 1 hit
PS50237 HECT, 1 hit
PS51416 MIB_HERC2, 1 hit
PS00626 RCC1_2, 1 hit
PS50012 RCC1_3, 18 hits
PS50030 UBA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHERC2_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VR91
Secondary accession number(s): Q8MZ96, Q9N2R1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: October 16, 2019
This is version 148 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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