Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 154 (13 Nov 2019)
Sequence version 1 (01 May 2000)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Translational regulator orb2

Gene

orb2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required in mushroom body gamma neurons for long-term memory in male courtship (PubMed:17965711, PubMed:23083740). Binds to mRNA 3'-UTRs (PubMed:20547833, PubMed:26638074, PubMed:24830287, PubMed:26095367). In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover (PubMed:20547833, PubMed:26638074). In its amyloid-like oligomeric form, acts as a translational activator (PubMed:26638074). The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA (PubMed:26638074). Isoform A is required for initial memory acquisition and, following subsequent late dopaminergic pathway activation, isoform A recruits isoform B into a complex to activate translation of CaMKII which is required for long-term memory consolidation (PubMed:26095367). Involved in asymmetric cell division in the central nervous system (PubMed:21900268). Required for the progression of spermatogenesis through meiosis and for sperm differentiation (PubMed:23209437). During sperm differentiation, required to asymmetrically localize and activate the translation of protein kinase aPKC mRNAs which is necessary for spermatid cyst polarization (PubMed:24830287). Also required during spermatid cyst polarization for localization and translation of its own mRNA (PubMed:24830287).8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor, RNA-binding
Biological processCell cycle, Cell division, Differentiation, Spermatogenesis, Translation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translational regulator orb2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:orb2Imported
ORF Names:CG43782
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0264307 orb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Cell junction, Cell projection, Cytoplasm, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Substantially reduced viability with surviving males being completely sterile due to a failure of spermatocytes to complete meiosis with arrest happening at the G2-M transition (PubMed:23209437). Defective spermatid cyst polarization (PubMed:24830287).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002323961 – 704Translational regulator orb2Add BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei74Phosphoserine1 Publication1
Modified residuei88Phosphoserine1 Publication1
Modified residuei100Phosphoserine1 Publication1
Modified residuei425Phosphoserine1 Publication1
Modified residuei428Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation regulates interaction with Tob and oligomerization. Protein phosphatase 2A keeps both Orb2 and Tob in an unphosphorylated form. Following synaptic activation, unphosphorylated Orb2 is bound and stabilized by unphosphorylated Tob. Tob recruits activated LimK which phosphorylates both Orb2 and Tob and enhances Orb2 oligomerization.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VSR3

PRoteomics IDEntifications database

More...
PRIDEi
Q9VSR3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VSR3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed throughout the nervous system of embryo, larva and adult including the ventral nerve cord and brain (at protein level) (PubMed:23083740). In early embryos, deposited maternally and distributed uniformly throughout the embryo until the extended germband stage (PubMed:21900268). By mid-embryogenesis, highest levels are found in the central and peripheral nervous systems with lower expression also detected in the ectoderm and mesoderm (PubMed:21900268). In adults, high levels are present in the head and body of both sexes with higher expression in testis than ovary (PubMed:21900268). In the ovary, expressed in both germ and follicle cells (PubMed:21900268). In adult head, predominantly neuronal with broad expression throughout the brain and ventral ganglia including the mushroom body (PubMed:17965711, PubMed:21900268).3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout development in both the soma and germline. Widely expressed in early embryos with levels dropping during mid-embryogenesis and increasing again in late embryogenesis. Expression is relatively low during larval stages with lowest levels in the first and second instars and an increase during the third instar. Levels increase substantially during the pupal stage and remain relatively high in the adult. In the ovary, little expression in the germarium or previtellogenic stage chambers with levels increasing midway through oogenesis and remaining high until stage 10 (PubMed:21900268). In the testis, there is substantial up-regulation after mitosis is finished and the interconnected spermatocytes begin to grow (PubMed:23209437). Expression peaks as the mature spermatocytes go through meiosis and high levels are found in 32- and 64-cell spermatid cysts with expression persisting after the spermatids in the 64-cell cysts start differentiation and disappearing once elongation and nuclear condensation are completed (PubMed:23209437).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0264307 Expressed in 29 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VSR3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VSR3 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:22284910, PubMed:23083740). Upon neuronal stimulation, forms stable amyloid-like oligomers composed of isoform A and isoform B which are required for formation of persistent long-term memory (PubMed:22284910, PubMed:23083740). Isoform A is critical for oligomer formation (PubMed:22284910, PubMed:23083740). Phe-5 of isoform A is required for amyloid-like oligomerization (PubMed:22284910, PubMed:26812143). Rapidly forms amyloids and toxic intermediates are extremely transient (PubMed:26812143).

Interacts with the translational regulator bol (PubMed:23209437).

Interacts with Tob; the interaction is enhanced by neuronal stimulation, stabilizes isoform A and induces oligomerization (PubMed:24523662).

5 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
64423, 80 interactors

Database of interacting proteins

More...
DIPi
DIP-49224N

Protein interaction database and analysis system

More...
IntActi
Q9VSR3, 13 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0303905

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VSR3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini447 – 538RRM 1PROSITE-ProRule annotationAdd BLAST92
Domaini555 – 637RRM 2PROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 103Ser-richSequence analysisAdd BLAST93
Compositional biasi176 – 221Gln/His-richSequence analysisAdd BLAST46
Compositional biasi226 – 371Gly-richSequence analysisAdd BLAST146

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Isoform A: The N-terminal Gln/His-rich domain is necessary and sufficient for long-term memory and is required for formation of amyloid-like oligomers with isoform B (PubMed:17965711, PubMed:23083740). Isoform B: The N-terminal Gln/His-rich domain is both dispensable and insufficient for long-term memory and for formation of amyloid-like oligomers with isoform A (PubMed:23083740).2 Publications
Isoform A: The RNA-binding region is not essential for long-term memory. Isoform B: The RNA-binding region is essential for long-term memory.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0129 Eukaryota
ENOG410Y1XZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169843

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VSR3

KEGG Orthology (KO)

More...
KOi
K02602

Identification of Orthologs from Complete Genome Data

More...
OMAi
SDYMRGM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.130, 1 hit
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032296 CEBP_ZZ
IPR038446 CEBP_ZZ_sf
IPR034819 CPEB
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12566 PTHR12566, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16366 CEBP_ZZ, 1 hit
PF16367 RRM_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform BImported (identifier: Q9VSR3-1) [UniParc]FASTAAdd to basket
Also known as: CImported, Orb2B1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSLKLPKAN SATSSASGSN SNLSGSTSAS ASAATSPTSS GTAVGGILSG
60 70 80 90 100
APKSPPGLGS STPISVRFNA NEESLDDILQ SFHHSKHSPS GGASGGGDAS
110 120 130 140 150
PTSNLLGMKN NGLGLVVGNC DSLSSSPSQP QMHAGSASLF GNDEVSLRNN
160 170 180 190 200
FMQAGGFFNR KSCGGLPNLN LNKPPQLHQQ QHQQQHQQHQ QHQQQQQLHQ
210 220 230 240 250
HQQQLSPNLS ALHHHHQQQQ QLRESGGSHS PSSPGGGGGG SPYNGSQAGC
260 270 280 290 300
SSGGISPIPP QMGVSPKYRR SISFPIKGNS PTAIYGNMHM DGMGSGHMNI
310 320 330 340 350
PTLSIGNGGG GGSTGMVSAG ATGGGDAPYL GNSYGNMMTS NGQMHHGGGL
360 370 380 390 400
DNSLCDYMRN MSLGGNGGGD GSNSMSLMQD RMRVMGGPKH LSEADAMAIA
410 420 430 440 450
ASGNDPSVYL NALKMGSPSR LSPHSPHSPI QGGNGGNVGD GTARFSRKVF
460 470 480 490 500
VGGLPPDIDE DEITTSFRRF GPLVVDWPHK AESKSYFPPK GYAFLLFQDE
510 520 530 540 550
SSVQQLIDSC ITDEDKLYLC VSSPTIKDKA VQIRPWRLAD ADYVLDATMS
560 570 580 590 600
LDPRKTVFVG GVPRPLKAFE LAMIMDRLYG GVCYAGIDTD PELKYPKGAG
610 620 630 640 650
RVAFSNQQSY IAAISARFVQ LQHGDIDKRV EVKPYVLDDQ MCDECEGQRC
660 670 680 690 700
GGKFAPFFCA NVTCLQYYCE HCWAVIHSRP GREYHKPLVK EGADRPRAVP

FRWC
Note: No experimental confirmation available.Curated
Length:704
Mass (Da):74,504
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4C8BD564C5F6432
GO
Isoform AImported (identifier: Q9VSR3-2) [UniParc]FASTAAdd to basket
Also known as: Orb2A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     2-9: DSLKLPKA → YNKFVNFI
     10-162: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:551
Mass (Da):59,706
Checksum:i0CEA5FF381F6E091
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A4V1P2A4V1P2_DROME
Orb2, isoform B
orb2 anon-WO0140519.222, CG43113, CG5735, cg5735, Dmel\CG43782
704Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4D6K616A0A4D6K616_DROME
Orb2, isoform J
orb2 anon-WO0140519.222, CG43113, CG5735, cg5735, Dmel\CG43782
769Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4D6K784A0A4D6K784_DROME
Orb2, isoform K
orb2 anon-WO0140519.222, CG43113, CG5735, cg5735, Dmel\CG43782
709Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL25391 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0519992 – 9DSLKLPKA → YNKFVNFI in isoform A. 1 Publication8
Alternative sequenceiVSP_05200010 – 162Missing in isoform A. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50350.1
AE014296 Genomic DNA Translation: AAF50352.1
AY052043 mRNA Translation: AAK93467.1
AY060352 mRNA Translation: AAL25391.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_001261608.1, NM_001274679.1 [Q9VSR3-1]
NP_648266.1, NM_140009.3 [Q9VSR3-1]
NP_729427.1, NM_168300.3 [Q9VSR3-1]
NP_729428.1, NM_168301.3 [Q9VSR3-1]
NP_729429.1, NM_168302.3 [Q9VSR3-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0331511; FBpp0303901; FBgn0264307 [Q9VSR3-2]
FBtr0331512; FBpp0303902; FBgn0264307 [Q9VSR3-1]
FBtr0331513; FBpp0303903; FBgn0264307 [Q9VSR3-1]
FBtr0331514; FBpp0303904; FBgn0264307 [Q9VSR3-1]
FBtr0331515; FBpp0303905; FBgn0264307 [Q9VSR3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39018

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG43782

UCSC genome browser

More...
UCSCi
CG5735-RA d. melanogaster [Q9VSR3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50350.1
AE014296 Genomic DNA Translation: AAF50352.1
AY052043 mRNA Translation: AAK93467.1
AY060352 mRNA Translation: AAL25391.1 Sequence problems.
RefSeqiNP_001261608.1, NM_001274679.1 [Q9VSR3-1]
NP_648266.1, NM_140009.3 [Q9VSR3-1]
NP_729427.1, NM_168300.3 [Q9VSR3-1]
NP_729428.1, NM_168301.3 [Q9VSR3-1]
NP_729429.1, NM_168302.3 [Q9VSR3-2]

3D structure databases

SMRiQ9VSR3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi64423, 80 interactors
DIPiDIP-49224N
IntActiQ9VSR3, 13 interactors
STRINGi7227.FBpp0303905

PTM databases

iPTMnetiQ9VSR3

Proteomic databases

PaxDbiQ9VSR3
PRIDEiQ9VSR3

Genome annotation databases

EnsemblMetazoaiFBtr0331511; FBpp0303901; FBgn0264307 [Q9VSR3-2]
FBtr0331512; FBpp0303902; FBgn0264307 [Q9VSR3-1]
FBtr0331513; FBpp0303903; FBgn0264307 [Q9VSR3-1]
FBtr0331514; FBpp0303904; FBgn0264307 [Q9VSR3-1]
FBtr0331515; FBpp0303905; FBgn0264307 [Q9VSR3-1]
GeneIDi39018
KEGGidme:Dmel_CG43782
UCSCiCG5735-RA d. melanogaster [Q9VSR3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39018
FlyBaseiFBgn0264307 orb2

Phylogenomic databases

eggNOGiKOG0129 Eukaryota
ENOG410Y1XZ LUCA
GeneTreeiENSGT00940000169843
InParanoidiQ9VSR3
KOiK02602
OMAiSDYMRGM

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39018

Protein Ontology

More...
PROi
PR:Q9VSR3

Gene expression databases

BgeeiFBgn0264307 Expressed in 29 organ(s), highest expression level in testis
ExpressionAtlasiQ9VSR3 baseline and differential
GenevisibleiQ9VSR3 DM

Family and domain databases

Gene3Di3.30.40.130, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR032296 CEBP_ZZ
IPR038446 CEBP_ZZ_sf
IPR034819 CPEB
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR12566 PTHR12566, 1 hit
PfamiView protein in Pfam
PF16366 CEBP_ZZ, 1 hit
PF16367 RRM_7, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiORB2_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VSR3
Secondary accession number(s): Q95T31, Q9VSR2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: May 1, 2000
Last modified: November 13, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again