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Entry version 123 (16 Oct 2019)
Sequence version 2 (09 Jul 2014)
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Protein

MAP kinase-activating death domain protein

Gene

Rab3-GEF

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MAP kinase-activating death domain protein
Alternative name(s):
Rab3 guanyl-nucleotide exchange factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rab3-GEFImported
ORF Names:CG5627Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0030613 Rab3-GEF

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002781411 – 2084MAP kinase-activating death domain proteinAdd BLAST2084

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VXY2

PRoteomics IDEntifications database

More...
PRIDEi
Q9VXY2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0030613 Expressed in 3 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VXY2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VXY2 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
58797, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VXY2, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0298037

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VXY2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 352uDENNPROSITE-ProRule annotationAdd BLAST328
Domaini373 – 514cDENNPROSITE-ProRule annotationAdd BLAST142
Domaini516 – 678dDENNPROSITE-ProRule annotationAdd BLAST163
Domaini1490 – 1565DeathAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi122 – 154Gly-richAdd BLAST33
Compositional biasi206 – 216His-richAdd BLAST11
Compositional biasi735 – 839Ser-richAdd BLAST105
Compositional biasi1302 – 1450Ser-richAdd BLAST149
Compositional biasi1779 – 1827Gln-richAdd BLAST49
Compositional biasi1893 – 1995Pro-richAdd BLAST103
Compositional biasi2005 – 2077Ser-richAdd BLAST73

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MADD family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3570 Eukaryota
ENOG410XP23 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156718

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VXY2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13008 PTHR13008, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q9VXY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDQQKASLC PRLVDYMAIV GAHTTPPMPK GLQGLKAPPV QVPDLLRRYP
60 70 80 90 100
PSDHADFPLP LDMVYFCQPE GCTSVGPRRT GSAIRDMTSF VFALTDKDSG
110 120 130 140 150
KTRYGICVNF YRPIERPSSA AGSAGAGNDR PGNGGPGGHG GGAGGGAGGG
160 170 180 190 200
GRGGRRSSAF RRESWRKSME RSSDSAFSSD YRSNVAPSDS DRELTSRRDS
210 220 230 240 250
DQQRLHSHHS HHQPHHPSAS PAVPKLGLMA PSADSESGGS HSPSPRASRK
260 270 280 290 300
RTKLRNQSLT SLCIISHHPF FTTFRECLFI LKKLIDACNE SSSPKRVGAS
310 320 330 340 350
QKINRDNVWT VLTGHVSDAT PSIVLHDVRE IETWILRLLS TPVPVPGSTR
360 370 380 390 400
VEVEVLSPTV HEPLLFALPD HTRFSLVDFP LHLPLELLGV ETCLKVWTLI
410 420 430 440 450
MQENKVLFQS RDYNALSMSV MAFVTMLYPL EYMFPVIPLL PTCLSCAEQL
460 470 480 490 500
LLAPTPFVIG VPASFLVYKK NFRLPDDIWV VDLDSTKLTP PTGGYEEIPP
510 520 530 540 550
LPEPEGTILK NHLKQALTSM TATNTAVSSQ QLLPSVRDSL QEPPLLGVSQ
560 570 580 590 600
VRLPLQTPPH SAQASQRNSM SAQGTISSRQ PSPMNSPALN PFVYGTDVDS
610 620 630 640 650
VDVATRVAMV RFFNAQNTLA NFAEHTRTLR LYPRPVVAFQ INSFLRSRPR
660 670 680 690 700
ASQFLNQFAR TQAVEFLAEW SLTPTNVAFL RVQTGVMDPM QVGDKPKWFA
710 720 730 740 750
HALTPIRFSV WDDGSSLNGA LRSLKQLECQ PTDESGSDSE GADSSSSSYS
760 770 780 790 800
SLSDFVSEMA SSDLSPSLHD VFGSYNRPHV VPQTLSSNLD PALVYHPPSK
810 820 830 840 850
LQYPEGIADA VASKEEEDEE RADSPVSSSS SRSDLSSPSF NRDSEFDFQP
860 870 880 890 900
KGGQTLGSTT VGSGAAAPSF ELATPLAMRL EATIKMASIE QESDTVSTAT
910 920 930 940 950
GKTIAAGSKL QRHPSDSESR PEKKIPPPLT PPVKQPGVSN ILARTGSSGS
960 970 980 990 1000
SSSSPGRQSS QSSLFENFAS HAKELVRETT RQSSQEGLLA HVDKFTLHAK
1010 1020 1030 1040 1050
KAAGEASKQA LEVSKQAAGV SKNTLEDLTY VGKSTLGDLT KTAKEAATKK
1060 1070 1080 1090 1100
GIIKIEEHSA GGAGPPPKSP GSQLATHKQV QQSGGQGGGN NFFSAIGTDF
1110 1120 1130 1140 1150
NGLASSTSTM FSGMFGKKSQ QKQVPVQQKQ PNVSAGKAKS GINFDPFPGR
1160 1170 1180 1190 1200
KGLVERTPLI KHSGPRQTQE ELTRQQNQER SHSNAENQTF LKDVTNQVLA
1210 1220 1230 1240 1250
GEGVGWLKLN RFKKLMEDES YRTLVLSKLN KTLDKKIAPD DHIDDVCVTK
1260 1270 1280 1290 1300
PVWKGMLKCI QAIAGGLDVT FANFGLGGMA SVFQLMEVAH THYWSKEINE
1310 1320 1330 1340 1350
GSDMSSSLLS SHAASPMGSR ENLRSPSSPN GSHSALGSEW ASPQESRKSS
1360 1370 1380 1390 1400
TQLAHGGPGG SHSGAPINRR LSSADSQDGQ STTEMFKDML SQKRSALKNM
1410 1420 1430 1440 1450
LTSFDSDTTT SKDSKKSSGN LWSGKSTLSA GFRYTGGHLI NTSSSPSPDS
1460 1470 1480 1490 1500
PRVYLFEGLL GKDRLNLWNQ MQFWEDAFLD AVSQERDMIG MDQGPIEMME
1510 1520 1530 1540 1550
RYKSLSESER KRLEHDEDRL LSTMLYNLTA ILVMLNVAKD EIRRKIRRLL
1560 1570 1580 1590 1600
GKSHIGLVYS QEVHNVVDQI NNLNGNDIDL KPLGSRLLHR QSFTVHQGTD
1610 1620 1630 1640 1650
VNGPLRFMEV RDDGLVLRSV DGTIVERWWY ERLVNMTYSP KTKLLCLWRR
1660 1670 1680 1690 1700
NGGQTQLHKY YTRKCKELYN CIKEAMERGG TPTNVPELGG EFPVQDMNTG
1710 1720 1730 1740 1750
EGGLLQVCLE GVGLLFSNSK FFVRLDHIRK CFTQKGGIFV LEEYNPKTRN
1760 1770 1780 1790 1800
LIQRKYQSSM SDQICYSVLC VFSYVAAGQD QKKNPVVITP QIQDIHAQQK
1810 1820 1830 1840 1850
QKHQQQQQHQ QPQQQQQPHQ TTTQQNQPTA VASAVPTTTA PAGQVNPNRM
1860 1870 1880 1890 1900
TAKSQAGSIS IRHTVPMQKP TITMSTVQPQ ARMPAQVATA SVPVTVPVPP
1910 1920 1930 1940 1950
TPAPPTSNPA KLPQLPPRVP SQPSTESLAS ISSPPPKLRT PMSAPPGPPP
1960 1970 1980 1990 2000
AIPPRTGAIS RSGSVPAARS FVRQASANST PPQYTPQPPP PFVIPKRHSG
2010 2020 2030 2040 2050
LARASTLSSS TSPSMSSSSA SNHPGHSQSQ QRASHGSVAA VLQSMPEAEP
2060 2070 2080
GYGSGSGSIS GSSSGSGSAS GSIASASPQA HRKH
Length:2,084
Mass (Da):226,055
Last modified:July 9, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5F745B221A54F70
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8JUX2A8JUX2_DROME
Rab3 GDP-GTP exchange factor, isofo...
Rab3-GEF anon-EST:Posey246, BEST:GH21304, Dmel\CG5627, rab3-GEF, rab3-gef
2,124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NGF2M9NGF2_DROME
Rab3 GDP-GTP exchange factor, isofo...
Rab3-GEF anon-EST:Posey246, BEST:GH21304, Dmel\CG5627, rab3-GEF, rab3-gef
2,130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NEH3M9NEH3_DROME
Rab3 GDP-GTP exchange factor, isofo...
Rab3-GEF anon-EST:Posey246, BEST:GH21304, Dmel\CG5627, rab3-GEF, rab3-gef
1,822Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PJN3M9PJN3_DROME
Rab3 GDP-GTP exchange factor, isofo...
Rab3-GEF anon-EST:Posey246, BEST:GH21304, Dmel\CG5627, rab3-GEF, rab3-gef
1,819Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PEM6M9PEM6_DROME
Rab3 GDP-GTP exchange factor, isofo...
Rab3-GEF anon-EST:Posey246, BEST:GH21304, Dmel\CG5627, rab3-GEF, rab3-gef
2,154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S0X7U5A0A0S0X7U5_DROME
Rab3 GDP-GTP exchange factor, isofo...
Rab3-GEF anon-EST:Posey246, BEST:GH21304, Dmel\CG5627, rab3-GEF, rab3-gef
2,095Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Z1CGX2A0A1Z1CGX2_DROME
Rab3 GDP-GTP exchange factor, isofo...
Rab3-GEF anon-EST:Posey246, BEST:GH21304, Dmel\CG5627, rab3-GEF, rab3-gef
2,115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Z1CGY3A0A1Z1CGY3_DROME
Rab3 GDP-GTP exchange factor, isofo...
Rab3-GEF anon-EST:Posey246, BEST:GH21304, Dmel\CG5627, rab3-GEF, rab3-gef
1,882Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Z1CSK9A0A1Z1CSK9_DROME
Rab3 GDP-GTP exchange factor, isofo...
Rab3-GEF anon-EST:Posey246, BEST:GH21304, Dmel\CG5627, rab3-GEF, rab3-gef
2,147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM50740 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

<p>This subsection of the ‘Sequence’ section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at positions 2031 and 2063.2 Publications
Partially edited. Target of Adar.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti2031Q → R in RNA edited version. 1
Natural varianti2063S → G in RNA edited version. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48424.2
AY118880 mRNA Translation: AAM50740.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_573001.2, NM_132773.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0307207; FBpp0298036; FBgn0030613

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32442

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5627

UCSC genome browser

More...
UCSCi
CG5627-RA d. melanogaster

Keywords - Coding sequence diversityi

RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48424.2
AY118880 mRNA Translation: AAM50740.1 Different initiation.
RefSeqiNP_573001.2, NM_132773.3

3D structure databases

SMRiQ9VXY2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi58797, 2 interactors
IntActiQ9VXY2, 2 interactors
STRINGi7227.FBpp0298037

Proteomic databases

PaxDbiQ9VXY2
PRIDEiQ9VXY2

Genome annotation databases

EnsemblMetazoaiFBtr0307207; FBpp0298036; FBgn0030613
GeneIDi32442
KEGGidme:Dmel_CG5627
UCSCiCG5627-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
32442
FlyBaseiFBgn0030613 Rab3-GEF

Phylogenomic databases

eggNOGiKOG3570 Eukaryota
ENOG410XP23 LUCA
GeneTreeiENSGT00940000156718
InParanoidiQ9VXY2

Enzyme and pathway databases

ReactomeiR-DME-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32442

Protein Ontology

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PROi
PR:Q9VXY2

Gene expression databases

BgeeiFBgn0030613 Expressed in 3 organ(s), highest expression level in head
ExpressionAtlasiQ9VXY2 baseline and differential
GenevisibleiQ9VXY2 DM

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR13008 PTHR13008, 2 hits
PfamiView protein in Pfam
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMADD_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VXY2
Secondary accession number(s): Q8MSD8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 9, 2014
Last modified: October 16, 2019
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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