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Entry version 144 (03 Jul 2019)
Sequence version 1 (01 May 2000)
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Protein

Peptidoglycan-recognition protein SA

Gene

PGRP-SA

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE (PubMed:11106397, PubMed:16399077, PubMed:15448690). Has no activity against Gram-negative bacteria and fungi (PubMed:11742401). Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition (PubMed:11742401, PubMed:15448690). May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway (PubMed:14684822, PubMed:14722090, PubMed:11742401). Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) and lysine-type PGN (Lys-type PGN) (PubMed:15361936). Has some L,D-carboxypeptidase activity for DAP-type PGN, which are specific to prokaryotes, but not for Lys-type PGN (PubMed:15361936).6 Publications

Caution

Although suggested, the interaction with GNBP1 has not been experimentally demonstrated.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=21.4 µM for GlcNAc-MurNAc(anhydro)-L-Ala-gamma-D-Glu-meso-DAP-D-Ala1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei182PeptidoglycanCurated1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protease
    Biological processImmunity, Innate immunity

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-DME-6803157 Antimicrobial peptides

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Peptidoglycan-recognition protein SA (EC:3.4.17.131 Publication)
    Alternative name(s):
    Protein semmelweis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PGRP-SA
    Synonyms:seml
    ORF Names:CG11709
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

    Organism-specific databases

    Drosophila genome database

    More...
    FlyBasei
    FBgn0030310 PGRP-SA

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi37C → A: Does not affect activation of Toll pathway. 1 Publication1
    Mutagenesisi68H → A: Abolishes L,D-carboxypeptidase activity on DAP-type PGN. 1 Publication1
    Mutagenesisi70 – 71VT → AA: Strongly reduces PGN-binding and activation of Toll pathway. 1 Publication2
    Mutagenesisi74C → A: Abolishes activation of Toll pathway. 1 Publication1
    Mutagenesisi80C → Y in seml; induces susceptibility to Gram-positive bacterial infection. 1 Publication1
    Mutagenesisi90 – 91YH → AA: Strongly reduces PGN-binding and activation of Toll pathway. 1 Publication2
    Mutagenesisi96 – 98DFN → AAA: Strongly reduces PGN-binding and activation of Toll pathway. 1 Publication3
    Mutagenesisi101S → A: Increases PGN-binding and activation of Toll pathway. 1 Publication1
    Mutagenesisi126Y → A: Strongly reduces PGN-binding and activation of Toll pathway. 1 Publication1
    Mutagenesisi180I → A: Strongly reduces PGN-binding. 1 Publication1
    Mutagenesisi182T → Y: Abolishes PGN-binding and activation of Toll pathway. 1 Publication1
    Mutagenesisi184S → A or C: Abolishes PGN-binding and activation of Toll pathway. Abolishes L,D-carboxypeptidase activity on DAP-type PGN. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 261 PublicationAdd BLAST26
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002390627 – 203Peptidoglycan-recognition protein SAAdd BLAST177

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 160
    Disulfide bondi74 ↔ 80

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9VYX7

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9VYX7

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    In larvae, it is expressed in fat body. Also expressed in uninduced hemocytes and mbn-2 cells.2 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Strongly up-regulated by PGN from B.subtilis. Regulated by both imd/Relish and Toll pathways.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    FBgn0030310 Expressed in 26 organ(s), highest expression level in arthropod fat body

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9VYX7 differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9VYX7 DM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    GNBP1Q9NHB04EBI-15721239,EBI-15721168

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    58509, 2 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-60775N

    Protein interaction database and analysis system

    More...
    IntActi
    Q9VYX7, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    7227.FBpp0073358

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1203
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9VYX7

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9VYX7

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 186N-acetylmuramoyl-L-alanine amidaseSequence analysisAdd BLAST128

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni87 – 90Peptidoglycan bindingCurated4
    Regioni97 – 102Peptidoglycan bindingCurated6

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IYTD Eukaryota
    ENOG4111PQD LUCA

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9VYX7

    KEGG Orthology (KO)

    More...
    KOi
    K01446

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HTYGYNK

    Database of Orthologous Groups

    More...
    OrthoDBi
    1110472at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9VYX7

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd06583 PGRP, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.80.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036505 Amidase/PGRP_sf
    IPR002502 Amidase_domain
    IPR017331 Peptidoglycan_recognition
    IPR015510 PGRP
    IPR006619 PGRP_domain_met/bac

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11022 PTHR11022, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01510 Amidase_2, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF037945 PGRPs, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00644 Ami_2, 1 hit
    SM00701 PGRP, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55846 SSF55846, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q9VYX7-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MQPVRFGSPW IMAIGLVLLL LAFVSAGKSR QRSPANCPTI KLKRQWGGKP
    60 70 80 90 100
    SLGLHYQVRP IRYVVIHHTV TGECSGLLKC AEILQNMQAY HQNELDFNDI
    110 120 130 140 150
    SYNFLIGNDG IVYEGTGWGL RGAHTYGYNA IGTGIAFIGN FVDKLPSDAA
    160 170 180 190 200
    LQAAKDLLAC GVQQGELSED YALIAGSQVI STQSPGLTLY NEIQEWPHWL

    SNP
    Length:203
    Mass (Da):22,260
    Last modified:May 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD200A6EA79C66731
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    X2JEI8X2JEI8_DROME
    Peptidoglycan-recognition protein
    PGRP-SA BcDNA:AT30827, CG11709, Dm PGRP-SA, Dmel\CG11709, pgrp-sa
    203Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF207540 Genomic DNA Translation: AAG23734.1
    AF207541 mRNA Translation: AAG23735.1
    AJ556551 Genomic DNA Translation: CAD89116.1
    AJ556552 Genomic DNA Translation: CAD89117.1
    AJ556553 Genomic DNA Translation: CAD89118.1
    AJ556554 Genomic DNA Translation: CAD89119.1
    AJ556555 Genomic DNA Translation: CAD89120.1
    AJ556556 Genomic DNA Translation: CAD89121.1
    AJ556557 Genomic DNA Translation: CAD89122.1
    AJ556558 Genomic DNA Translation: CAD89123.1
    AJ556559 Genomic DNA Translation: CAD89124.1
    AJ556560 Genomic DNA Translation: CAD89125.1
    AJ556561 Genomic DNA Translation: CAD89126.1
    AE014298 Genomic DNA Translation: AAF48056.1
    AY075293 mRNA Translation: AAL68160.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001285128.1, NM_001298199.1
    NP_572727.1, NM_132499.3

    Genome annotation databases

    Ensembl metazoan genome annotation project

    More...
    EnsemblMetazoai
    FBtr0073509; FBpp0073358; FBgn0030310
    FBtr0340296; FBpp0309257; FBgn0030310

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    32099

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    dme:Dmel_CG11709

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF207540 Genomic DNA Translation: AAG23734.1
    AF207541 mRNA Translation: AAG23735.1
    AJ556551 Genomic DNA Translation: CAD89116.1
    AJ556552 Genomic DNA Translation: CAD89117.1
    AJ556553 Genomic DNA Translation: CAD89118.1
    AJ556554 Genomic DNA Translation: CAD89119.1
    AJ556555 Genomic DNA Translation: CAD89120.1
    AJ556556 Genomic DNA Translation: CAD89121.1
    AJ556557 Genomic DNA Translation: CAD89122.1
    AJ556558 Genomic DNA Translation: CAD89123.1
    AJ556559 Genomic DNA Translation: CAD89124.1
    AJ556560 Genomic DNA Translation: CAD89125.1
    AJ556561 Genomic DNA Translation: CAD89126.1
    AE014298 Genomic DNA Translation: AAF48056.1
    AY075293 mRNA Translation: AAL68160.1
    RefSeqiNP_001285128.1, NM_001298199.1
    NP_572727.1, NM_132499.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1S2JX-ray2.20A/B1-203[»]
    1SXRX-ray1.56A/B27-203[»]
    SMRiQ9VYX7
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi58509, 2 interactors
    DIPiDIP-60775N
    IntActiQ9VYX7, 1 interactor
    STRINGi7227.FBpp0073358

    Proteomic databases

    PaxDbiQ9VYX7
    PRIDEiQ9VYX7

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblMetazoaiFBtr0073509; FBpp0073358; FBgn0030310
    FBtr0340296; FBpp0309257; FBgn0030310
    GeneIDi32099
    KEGGidme:Dmel_CG11709

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    32099
    FlyBaseiFBgn0030310 PGRP-SA

    Phylogenomic databases

    eggNOGiENOG410IYTD Eukaryota
    ENOG4111PQD LUCA
    InParanoidiQ9VYX7
    KOiK01446
    OMAiHTYGYNK
    OrthoDBi1110472at2759
    PhylomeDBiQ9VYX7

    Enzyme and pathway databases

    ReactomeiR-DME-6803157 Antimicrobial peptides

    Miscellaneous databases

    EvolutionaryTraceiQ9VYX7

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    32099

    Protein Ontology

    More...
    PROi
    PR:Q9VYX7

    Gene expression databases

    BgeeiFBgn0030310 Expressed in 26 organ(s), highest expression level in arthropod fat body
    ExpressionAtlasiQ9VYX7 differential
    GenevisibleiQ9VYX7 DM

    Family and domain databases

    CDDicd06583 PGRP, 1 hit
    Gene3Di3.40.80.10, 1 hit
    InterProiView protein in InterPro
    IPR036505 Amidase/PGRP_sf
    IPR002502 Amidase_domain
    IPR017331 Peptidoglycan_recognition
    IPR015510 PGRP
    IPR006619 PGRP_domain_met/bac
    PANTHERiPTHR11022 PTHR11022, 1 hit
    PfamiView protein in Pfam
    PF01510 Amidase_2, 1 hit
    PIRSFiPIRSF037945 PGRPs, 1 hit
    SMARTiView protein in SMART
    SM00644 Ami_2, 1 hit
    SM00701 PGRP, 1 hit
    SUPFAMiSSF55846 SSF55846, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGPSA_DROME
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VYX7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: May 1, 2000
    Last modified: July 3, 2019
    This is version 144 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
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