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Entry version 161 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

LD35927p

Gene

Dmel\CG2258

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-5663213 RHO GTPases Activate WASPs and WAVEs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LD35927pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dmel\CG2258Imported
ORF Names:CG2258Imported, Dmel_CG2258Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0029997 CG2258

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9W3K6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0029997 Expressed in 27 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9W3K6, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0071064

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W3K6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 59SH3InterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni106 – 377DisorderedSequence analysisAdd BLAST272

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili491 – 511Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi136 – 213PolarSequence analysisAdd BLAST78
Compositional biasi214 – 228Pro-richSequence analysisAdd BLAST15
Compositional biasi229 – 330PolarSequence analysisAdd BLAST102
Compositional biasi332 – 346PolyampholyteSequence analysisAdd BLAST15
Compositional biasi355 – 375PolarSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4035 Eukaryota
ENOG410Y8WT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015725

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKNDTEQ

Database of Orthologous Groups

More...
OrthoDBi
649314at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11849 SH3_SPIN90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018556 DUF2013
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035514 SPIN90_SH3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09431 DUF2013, 1 hit
PF00018 SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W3K6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKALYDFQA VYPKTISFDE GEYFILYQTS ARQRNWWQVV SMKGNIGFVP
60 70 80 90 100
SNYVMKIKVE HDFLISFLNS SIESLEKCTD HEINGIMSKD ELLDRLREKK
110 120 130 140 150
HTMERLYAES SERDGDSSLS YSHSYSDKGS HRHSHPHPTQ SQTQLHSQHR
160 170 180 190 200
QHSPPPSGGS VGSQRLDMSK KSMSSPAVGS SCGLPQNQGM IESPSMGSMQ
210 220 230 240 250
FQGSSCTIQT PQQQQPLPAP PAPAPSPSAA SATPTAASTS KAATGGDVAQ
260 270 280 290 300
DNSITSEPSE TTTTTTTTSE DVVTTYKETS QMSTSQQHKP QNGSTASASI
310 320 330 340 350
SASASASALR SNGGNGKANG SATALHQELQ QEEADSAPDK SDDASAVQSD
360 370 380 390 400
DGCPANGDSA DNSQALDSID SPSHRQRGLS LGRIEEGATG GGQLKVESSD
410 420 430 440 450
VYQIVDALRR NTNLSFDLSC EALRVVLTSL EQLYNGAINP YLEAVAVHVT
460 470 480 490 500
GKVATPKELL GITHDAKRLQ YLFAQLADCK NDTEQRTWML YEDEEDIIQF
510 520 530 540 550
LEELVEILIN ADESISCYEM SCDQYQMFIN LVQYYQMETR WSIKRLLLKT
560 570 580 590 600
FTAACHLDYI IVDILLTSVL PLEIVEDMKT HFSNLDRFKQ LVKMLTIIFS
610 620 630 640 650
LGQPMPVNHQ DYLGVHFASF LLEIVEGNNP EVLVDMVIAL ILAFNQQFSE
660 670 680 690 700
HTYNVIIEGM QNLPSAKVFT EKLLLLLNRE DDPTRLLKHP NEHMNTVLRM
710 720 730 740 750
FIDIFSHPDT AGMFYTNDIK VLIDIVVRQL SDLDAGSTTR PCYLELCRRI
760 770 780 790 800
LRNTNYQEHQ HRKHDLMKIF TRIFCEETEC SASDQQLVRE IANEFPQLFK

A
Length:801
Mass (Da):89,234
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0F5C824663DC391
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46320.1
AY094822 mRNA Translation: AAM11175.1
AE014298 Genomic DNA Translation: AAS65280.1
AE014298 Genomic DNA Translation: AAS65281.1
AE014298 Genomic DNA Translation: AHN59471.1

NCBI Reference Sequences

More...
RefSeqi
NP_001285000.1, NM_001298071.1
NP_572439.1, NM_132211.2
NP_996371.1, NM_206648.2
NP_996372.1, NM_206649.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0071109; FBpp0071064; FBgn0029997
FBtr0071110; FBpp0071065; FBgn0029997
FBtr0071111; FBpp0071066; FBgn0029997
FBtr0340140; FBpp0309126; FBgn0029997

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31729

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2258

UCSC genome browser

More...
UCSCi
CG2258-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46320.1
AY094822 mRNA Translation: AAM11175.1
AE014298 Genomic DNA Translation: AAS65280.1
AE014298 Genomic DNA Translation: AAS65281.1
AE014298 Genomic DNA Translation: AHN59471.1
RefSeqiNP_001285000.1, NM_001298071.1
NP_572439.1, NM_132211.2
NP_996371.1, NM_206648.2
NP_996372.1, NM_206649.2

3D structure databases

SMRiQ9W3K6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9W3K6, 4 interactors
STRINGi7227.FBpp0071064

Proteomic databases

PRIDEiQ9W3K6

Genome annotation databases

EnsemblMetazoaiFBtr0071109; FBpp0071064; FBgn0029997
FBtr0071110; FBpp0071065; FBgn0029997
FBtr0071111; FBpp0071066; FBgn0029997
FBtr0340140; FBpp0309126; FBgn0029997
GeneIDi31729
KEGGidme:Dmel_CG2258
UCSCiCG2258-RA d. melanogaster

Organism-specific databases

FlyBaseiFBgn0029997 CG2258

Phylogenomic databases

eggNOGiKOG4035 Eukaryota
ENOG410Y8WT LUCA
GeneTreeiENSGT00390000015725
OMAiCKNDTEQ
OrthoDBi649314at2759

Enzyme and pathway databases

ReactomeiR-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-5663213 RHO GTPases Activate WASPs and WAVEs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CG2258 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31729

Gene expression databases

BgeeiFBgn0029997 Expressed in 27 organ(s), highest expression level in brain

Family and domain databases

CDDicd11849 SH3_SPIN90, 1 hit
InterProiView protein in InterPro
IPR018556 DUF2013
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035514 SPIN90_SH3
PfamiView protein in Pfam
PF09431 DUF2013, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W3K6_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W3K6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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