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Entry version 165 (31 Jul 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Histone chaperone ASF1A

Gene

ASF1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • histone binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone, Chromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone chaperone ASF1A
Alternative name(s):
Anti-silencing function protein 1 homolog A
Short name:
hAsf1
Short name:
hAsf1a
CCG1-interacting factor A
Short name:
CIA
Short name:
hCIA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASF1A
ORF Names:CGI-98, HSPC146
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20995 ASF1A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609189 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y294

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi36 – 37ED → AA: Abrogates interaction with HIRA and induction of senescence-associated heterochromatin foci. 2 Publications2
Mutagenesisi37D → A: Abrogates interaction with CHAF1B and HIRA. 1 Publication1
Mutagenesisi54D → R: Reduces interaction with histone H3. 1 Publication1
Mutagenesisi62 – 64VGP → AAA: Abrogates interaction with HIRA and induction of senescence-associated heterochromatin foci. 2 Publications3
Mutagenesisi94V → R: Abrogates interaction with histone H3 and histone H4. 1 Publication1
Mutagenesisi108R → E: Reduces interaction with histone H3. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
25842

Open Targets

More...
OpenTargetsi
ENSG00000111875

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394636

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3392950

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ASF1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74735206

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002840121 – 204Histone chaperone ASF1AAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei192Phosphoserine; by TLK21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y294

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y294

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9Y294

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y294

PeptideAtlas

More...
PeptideAtlasi
Q9Y294

PRoteomics IDEntifications database

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PRIDEi
Q9Y294

ProteomicsDB human proteome resource

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ProteomicsDBi
85702

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y294

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y294

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111875 Expressed in 230 organ(s), highest expression level in oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y294 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030502
HPA071495

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4.

Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex.

Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1.

Interacts with CDAN1.

Found in a cytosolic complex with CDAN1, ASF1B, IPO4 and histones H3.1 and H4.

Interacts with CREBBP.

14 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117368, 85 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y294

Database of interacting proteins

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DIPi
DIP-29241N

Protein interaction database and analysis system

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IntActi
Q9Y294, 40 interactors

Molecular INTeraction database

More...
MINTi
Q9Y294

STRING: functional protein association networks

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STRINGi
9606.ENSP00000229595

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y294

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y294

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9Y294

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 156Interaction with histone H3, CHAF1B, and HIRAAdd BLAST156
Regioni155 – 204Required for interaction with HIRAAdd BLAST50

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi31 – 37Required for interaction with HIRA7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ASF1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3265 Eukaryota
COG5137 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004692

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000197425

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y294

KEGG Orthology (KO)

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KOi
K10753

Identification of Orthologs from Complete Genome Data

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OMAi
YADPEMR

Database of Orthologous Groups

More...
OrthoDBi
266497at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y294

TreeFam database of animal gene trees

More...
TreeFami
TF106429

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.1490, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006818 ASF1-like
IPR036747 ASF1-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12040 PTHR12040, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04729 ASF1_hist_chap, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101546 SSF101546, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y294-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVQVNNVV VLDNPSPFYN PFQFEITFEC IEDLSEDLEW KIIYVGSAES
60 70 80 90 100
EEYDQVLDSV LVGPVPAGRH MFVFQADAPN PGLIPDADAV GVTVVLITCT
110 120 130 140 150
YRGQEFIRVG YYVNNEYTET ELRENPPVKP DFSKLQRNIL ASNPRVTRFH
160 170 180 190 200
INWEDNTEKL EDAESSNPNL QSLLSTDALP SASKGWSTSE NSLNVMLESH

MDCM
Length:204
Mass (Da):22,969
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9819D531D3A9FC68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74F → I in AAF29110 (PubMed:11042152).Curated1
Sequence conflicti204M → I in CAG33628 (Ref. 7) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB028628 mRNA Translation: BAA96542.1
AF279306 mRNA Translation: AAK82972.1
AF151856 mRNA Translation: AAD34093.1
AF161495 mRNA Translation: AAF29110.1
AL050261 mRNA Translation: CAB43363.1
AK025738 mRNA Translation: BAB15228.1
CR457347 mRNA Translation: CAG33628.1
AC022098 Genomic DNA No translation available.
BC010878 mRNA Translation: AAH10878.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47469.1

Protein sequence database of the Protein Information Resource

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PIRi
T08661

NCBI Reference Sequences

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RefSeqi
NP_054753.1, NM_014034.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000229595; ENSP00000229595; ENSG00000111875

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25842

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25842

UCSC genome browser

More...
UCSCi
uc011ebn.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028628 mRNA Translation: BAA96542.1
AF279306 mRNA Translation: AAK82972.1
AF151856 mRNA Translation: AAD34093.1
AF161495 mRNA Translation: AAF29110.1
AL050261 mRNA Translation: CAB43363.1
AK025738 mRNA Translation: BAB15228.1
CR457347 mRNA Translation: CAG33628.1
AC022098 Genomic DNA No translation available.
BC010878 mRNA Translation: AAH10878.1
CCDSiCCDS47469.1
PIRiT08661
RefSeqiNP_054753.1, NM_014034.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TEYNMR-A1-156[»]
2I32X-ray2.70A/B1-157[»]
2IIJNMR-A1-156[»]
2IO5X-ray2.70A1-172[»]
3AADX-ray3.30B/D1-155[»]
5C3IX-ray3.50A/E/I/M/Q/U1-175[»]
6F0FX-ray2.00A1-156[»]
6F0GX-ray2.30A/B1-156[»]
6F0HX-ray1.98A/C1-156[»]
SMRiQ9Y294
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117368, 85 interactors
CORUMiQ9Y294
DIPiDIP-29241N
IntActiQ9Y294, 40 interactors
MINTiQ9Y294
STRINGi9606.ENSP00000229595

Chemistry databases

BindingDBiQ9Y294
ChEMBLiCHEMBL3392950

PTM databases

iPTMnetiQ9Y294
PhosphoSitePlusiQ9Y294

Polymorphism and mutation databases

BioMutaiASF1A
DMDMi74735206

Proteomic databases

EPDiQ9Y294
jPOSTiQ9Y294
MaxQBiQ9Y294
PaxDbiQ9Y294
PeptideAtlasiQ9Y294
PRIDEiQ9Y294
ProteomicsDBi85702

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25842
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229595; ENSP00000229595; ENSG00000111875
GeneIDi25842
KEGGihsa:25842
UCSCiuc011ebn.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25842
DisGeNETi25842

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ASF1A
HGNCiHGNC:20995 ASF1A
HPAiHPA030502
HPA071495
MIMi609189 gene
neXtProtiNX_Q9Y294
OpenTargetsiENSG00000111875
PharmGKBiPA128394636

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3265 Eukaryota
COG5137 LUCA
GeneTreeiENSGT00390000004692
HOGENOMiHOG000197425
InParanoidiQ9Y294
KOiK10753
OMAiYADPEMR
OrthoDBi266497at2759
PhylomeDBiQ9Y294
TreeFamiTF106429

Enzyme and pathway databases

ReactomeiR-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Miscellaneous databases

EvolutionaryTraceiQ9Y294

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ASF1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25842

Protein Ontology

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PROi
PR:Q9Y294

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111875 Expressed in 230 organ(s), highest expression level in oocyte
GenevisibleiQ9Y294 HS

Family and domain databases

Gene3Di2.60.40.1490, 1 hit
InterProiView protein in InterPro
IPR006818 ASF1-like
IPR036747 ASF1-like_sf
PANTHERiPTHR12040 PTHR12040, 1 hit
PfamiView protein in Pfam
PF04729 ASF1_hist_chap, 1 hit
SUPFAMiSSF101546 SSF101546, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASF1A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y294
Secondary accession number(s): Q6IA08, Q9P014
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 1, 1999
Last modified: July 31, 2019
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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