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Entry version 154 (16 Oct 2019)
Sequence version 2 (12 Apr 2005)
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Protein

Mediator of RNA polymerase II transcription subunit 16

Gene

MED16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.2 Publications

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y2X0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 16
Alternative name(s):
Mediator complex subunit 16
Thyroid hormone receptor-associated protein 5
Thyroid hormone receptor-associated protein complex 95 kDa component
Short name:
Trap95
Vitamin D3 receptor-interacting protein complex 92 kDa component
Short name:
DRIP92
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED16
Synonyms:DRIP92Imported, THRAP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17556 MED16

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604062 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2X0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10025

Open Targets

More...
OpenTargetsi
ENSG00000175221

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162395406

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2X0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MED16

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62511180

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000512921 – 877Mediator of RNA polymerase II transcription subunit 16Add BLAST877

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2X0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y2X0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2X0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2X0

PeptideAtlas

More...
PeptideAtlasi
Q9Y2X0

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2X0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85922 [Q9Y2X0-1]
85923 [Q9Y2X0-2]
85924 [Q9Y2X0-3]
85925 [Q9Y2X0-4]
85926 [Q9Y2X0-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2X0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2X0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175221 Expressed in 217 organ(s), highest expression level in tendon of biceps brachii

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2X0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2X0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030685
HPA046495

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115342, 74 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3227 Core mediator complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y2X0

Database of interacting proteins

More...
DIPi
DIP-31463N

Protein interaction database and analysis system

More...
IntActi
Q9Y2X0, 37 interactors

Molecular INTeraction database

More...
MINTi
Q9Y2X0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325612

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati21 – 71WD 1Add BLAST51
Repeati72 – 119WD 2Add BLAST48
Repeati120 – 165WD 3Add BLAST46
Repeati166 – 203WD 4Add BLAST38
Repeati204 – 257WD 5Add BLAST54
Repeati258 – 334WD 6Add BLAST77
Repeati335 – 415WD 7Add BLAST81
Repeati416 – 460WD 8Add BLAST45
Repeati461 – 495WD 9Add BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 16 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDXV Eukaryota
ENOG410ZRDM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003821

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113526

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2X0

KEGG Orthology (KO)

More...
KOi
K15159

Identification of Orthologs from Complete Genome Data

More...
OMAi
VNEKCRI

Database of Orthologous Groups

More...
OrthoDBi
493637at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2X0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021665 Mediator_Med16
IPR011041 Quinoprot_gluc/sorb_DH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13224 PTHR13224, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11635 Med16, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50952 SSF50952, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9Y2X0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCDLRRPAAG GMMDLAYVCE WEKWSKSTHC PSVPLACAWS CRNLIAFTMD
60 70 80 90 100
LRSDDQDLTR MIHILDTEHP WDLHSIPSEH HEAITCLEWD QSGSRLLSAD
110 120 130 140 150
ADGQIKCWSM ADHLANSWES SVGSLVEGDP IVALSWLHNG VKLALHVEKS
160 170 180 190 200
GASSFGEKFS RVKFSPSLTL FGGKPMEGWI AVTVSGLVTV SLLKPSGQVL
210 220 230 240 250
TSTESLCRLR GRVALADIAF TGGGNIVVAT ADGSSASPVQ FYKVCVSVVS
260 270 280 290 300
EKCRIDTEIL PSLFMRCTTD LNRKDKFPAI THLKFLARDM SEQVLLCASS
310 320 330 340 350
QTSSIVECWS LRKEGLPVNN IFQQISPVVG DKQPTILKWR ILSATNDLDR
360 370 380 390 400
VSAVALPKLP ISLTNTDLKV ASDTQFYPGL GLALAFHDGS VHIVHRLSLQ
410 420 430 440 450
TMAVFYSSAA PRPVDEPAMK RPRTAGPAVH LKAMQLSWTS LALVGIDSHG
460 470 480 490 500
KLSVLRLSPS MGHPLEVGLA LRHLLFLLEY CMVTGYDWWD ILLHVQPSMV
510 520 530 540 550
QSLVEKLHEE YTRQTAALQQ VLSTRILAMK ASLCKLSPCT VTRVCDYHTK
560 570 580 590 600
LFLIAISSTL KSLLRPHFLN TPDKSPGDRL TEICTKITDV DIDKVMINLK
610 620 630 640 650
TEEFVLDMNT LQALQQLLQW VGDFVLYLLA SLPNQGSLLR PGHSFLRDGT
660 670 680 690 700
SLGMLRELMV VIRIWGLLKP SCLPVYTATS DTQDSMSLLF RLLTKLWICC
710 720 730 740 750
RDEGPASEPD EALVDECCLL PSQLLIPSLD WLPASDGLVS RLQPKQPLRL
760 770 780 790 800
QFGRAPTLPG SAATLQLDGL ARAPGQPKID HLRRLHLGAC PTEECKACTR
810 820 830 840 850
CGCVTMLKSP NRTTAVKQWE QRWIKNCLAV EGRGPDACVT SRASEEAPAF
860 870
VQLGPQSTHH SPRTPRSLDH LHPEDRP
Length:877
Mass (Da):96,793
Last modified:April 12, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15173F237A75D230
GO
Isoform 2Curated (identifier: Q9Y2X0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-877: AVEGRGPDACVTSRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP → CGGLWWRVPLSYP

Show »
Length:841
Mass (Da):93,029
Checksum:i2D9CAF68001320C3
GO
Isoform 3Curated (identifier: Q9Y2X0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     700-700: C → FPSTGPCSVWVLLGWQPLPG
     829-877: AVEGRGPDACVTSRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP → CGGLWWRVPLSYP

Note: No experimental confirmation available.Curated
Show »
Length:860
Mass (Da):95,050
Checksum:i546EA25BE3AB56CF
GO
Isoform 4Curated (identifier: Q9Y2X0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-751: GSLLRPGHSF...LQPKQPLRLQ → VAMRAQRASR...CSSRPTEPRR
     752-877: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:751
Mass (Da):82,179
Checksum:i6B77C11B864902BD
GO
Isoform 5 (identifier: Q9Y2X0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-663: GSLLRPGHSFLRDGTSLGMLRELMVVIR → PCPTSEPCPTSEPSPTSEPSPTSEPSSP
     664-877: Missing.

Note: No experimental confirmation available.
Show »
Length:663
Mass (Da):72,967
Checksum:i311F7B98C3912283
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQ43U3KQ43_HUMAN
Mediator of RNA polymerase II trans...
MED16
663Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9TWZ6B9TWZ6_HUMAN
Mediator of RNA polymerase II trans...
MED16
537Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXA0A0A0J9YXA0_HUMAN
Mediator of RNA polymerase II trans...
MED16
497Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXL6A0A0J9YXL6_HUMAN
Mediator of RNA polymerase II trans...
MED16
283Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9TX11B9TX11_HUMAN
Mediator of RNA polymerase II trans...
MED16
219Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9TX12B9TX12_HUMAN
Mediator of RNA polymerase II trans...
MED16
218Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKS6K7EKS6_HUMAN
Mediator of RNA polymerase II trans...
MED16
462Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQB4U3KQB4_HUMAN
Mediator of RNA polymerase II trans...
MED16
505Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YW49A0A0J9YW49_HUMAN
Mediator of RNA polymerase II trans...
MED16
371Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU12A0A087WU12_HUMAN
Mediator of RNA polymerase II trans...
MED16
79Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD31087 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46A → T in AAD30032 (PubMed:10198638).Curated1
Sequence conflicti211G → A in AAD31087 (PubMed:10235266).Curated1
Sequence conflicti412R → K in AAD30032 (PubMed:10198638).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053958770L → F. Corresponds to variant dbSNP:rs34859566Ensembl.1
Natural variantiVAR_053959874E → K. Corresponds to variant dbSNP:rs13090Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051721636 – 751GSLLR…PLRLQ → VAMRAQRASRTRRWWMNAAC CPASCLSPAWTGCQPATAWL AACSPSSPFVCSLAGRPRCL AVLPPCSSTASPGPQASPRS TTCGGCTLALAPRRNARPAP GAAVSPCSSRPTEPRR in isoform 4. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_028749636 – 663GSLLR…MVVIR → PCPTSEPCPTSEPSPTSEPS PTSEPSSP in isoform 5. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_028750664 – 877Missing in isoform 5. 1 PublicationAdd BLAST214
Alternative sequenceiVSP_051722700C → FPSTGPCSVWVLLGWQPLPG in isoform 3. 1 Publication1
Alternative sequenceiVSP_051723752 – 877Missing in isoform 4. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_051724829 – 877AVEGR…PEDRP → CGGLWWRVPLSYP in isoform 2 and isoform 3. 2 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF121228 mRNA Translation: AAD30032.1
AF106934 mRNA Translation: AAD31087.1 Frameshift.
BC004554 mRNA Translation: AAH04554.1
BC007853 mRNA Translation: AAH07853.2
BC011841 mRNA Translation: AAH11841.1
BC017282 mRNA Translation: AAH17282.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12047.1 [Q9Y2X0-1]

NCBI Reference Sequences

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RefSeqi
NP_005472.2, NM_005481.2 [Q9Y2X0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000312090; ENSP00000308528; ENSG00000175221 [Q9Y2X0-3]
ENST00000325464; ENSP00000325612; ENSG00000175221 [Q9Y2X0-1]
ENST00000395808; ENSP00000379153; ENSG00000175221 [Q9Y2X0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10025

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10025

UCSC genome browser

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UCSCi
uc002lqd.2 human [Q9Y2X0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121228 mRNA Translation: AAD30032.1
AF106934 mRNA Translation: AAD31087.1 Frameshift.
BC004554 mRNA Translation: AAH04554.1
BC007853 mRNA Translation: AAH07853.2
BC011841 mRNA Translation: AAH11841.1
BC017282 mRNA Translation: AAH17282.1
CCDSiCCDS12047.1 [Q9Y2X0-1]
RefSeqiNP_005472.2, NM_005481.2 [Q9Y2X0-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi115342, 74 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiQ9Y2X0
DIPiDIP-31463N
IntActiQ9Y2X0, 37 interactors
MINTiQ9Y2X0
STRINGi9606.ENSP00000325612

PTM databases

iPTMnetiQ9Y2X0
PhosphoSitePlusiQ9Y2X0

Polymorphism and mutation databases

BioMutaiMED16
DMDMi62511180

Proteomic databases

EPDiQ9Y2X0
jPOSTiQ9Y2X0
MassIVEiQ9Y2X0
PaxDbiQ9Y2X0
PeptideAtlasiQ9Y2X0
PRIDEiQ9Y2X0
ProteomicsDBi85922 [Q9Y2X0-1]
85923 [Q9Y2X0-2]
85924 [Q9Y2X0-3]
85925 [Q9Y2X0-4]
85926 [Q9Y2X0-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10025

Genome annotation databases

EnsembliENST00000312090; ENSP00000308528; ENSG00000175221 [Q9Y2X0-3]
ENST00000325464; ENSP00000325612; ENSG00000175221 [Q9Y2X0-1]
ENST00000395808; ENSP00000379153; ENSG00000175221 [Q9Y2X0-2]
GeneIDi10025
KEGGihsa:10025
UCSCiuc002lqd.2 human [Q9Y2X0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10025
DisGeNETi10025

GeneCards: human genes, protein and diseases

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GeneCardsi
MED16
HGNCiHGNC:17556 MED16
HPAiHPA030685
HPA046495
MIMi604062 gene
neXtProtiNX_Q9Y2X0
OpenTargetsiENSG00000175221
PharmGKBiPA162395406

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IDXV Eukaryota
ENOG410ZRDM LUCA
GeneTreeiENSGT00390000003821
HOGENOMiHOG000113526
InParanoidiQ9Y2X0
KOiK15159
OMAiVNEKCRI
OrthoDBi493637at2759
PhylomeDBiQ9Y2X0

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkiQ9Y2X0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MED16 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MED16

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10025
PharosiQ9Y2X0

Protein Ontology

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PROi
PR:Q9Y2X0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175221 Expressed in 217 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiQ9Y2X0 baseline and differential
GenevisibleiQ9Y2X0 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR021665 Mediator_Med16
IPR011041 Quinoprot_gluc/sorb_DH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13224 PTHR13224, 1 hit
PfamiView protein in Pfam
PF11635 Med16, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 1 hit
SUPFAMiSSF50952 SSF50952, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED16_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2X0
Secondary accession number(s): Q6PJT2
, Q96AD4, Q96I35, Q9Y652
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: October 16, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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