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Entry version 136 (08 May 2019)
Sequence version 4 (18 May 2010)
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Protein

RWD domain-containing protein 3

Gene

RWDD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9Y3V2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RWD domain-containing protein 3
Alternative name(s):
RWD domain-containing sumoylation enhancer
Short name:
RSUME1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RWDD3
Synonyms:RSUME
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:21393 RWDD3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615875 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y3V2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi61 – 62YP → AA: Abolishes enhancement of NFKBIA and NR3C1 sumoylation. No effect on NR3C1 transcriptional activity. 2 Publications2

Organism-specific databases

DisGeNET

More...
DisGeNETi
25950

Open Targets

More...
OpenTargetsi
ENSG00000122481

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134974302

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RWDD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975451 – 267RWD domain-containing protein 3Add BLAST267

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y3V2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y3V2

PeptideAtlas

More...
PeptideAtlasi
Q9Y3V2

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y3V2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86080
86081 [Q9Y3V2-2]
86082 [Q9Y3V2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y3V2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y3V2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are expressed in glioma tumors (at protein level). Expressed in a wide number of tissues with highest expression in cerebellum, pituitary, heart, kidney, liver, stomach, pancreas, prostate and spleen. Low levels in thalamus, spinal cord, esophagus, thymus, lung and peripheral blood leukocytes. A higher level expression seen in pituitary tumors as compared to the pituitary gland.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by hypoxia and heat shock.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122481 Expressed in 91 organ(s), highest expression level in caudate nucleus

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y3V2 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 and isoform 2 interact with UBE2I/UBC9 (PubMed:17956732, PubMed:23469069, PubMed:25918163). Isoform 1 shows a greater interaction with NFKBIA and HIF1A as compared to isoform 2 (PubMed:17956732, PubMed:23469069). Isoform 2 interacts with NCOA2 and NR3C1 (PubMed:23508108).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117445, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y3V2, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359221

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1267
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBKNMR-A1-121[»]
4Y1LX-ray2.70C2-113[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y3V2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y3V2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 114RWDPROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni13 – 15Interaction with UBE2I/UBC91 Publication3
Regioni100 – 102Interaction with UBE2I/UBC91 Publication3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RWD domain is required for the sumoylation enhancement activity.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGD3 Eukaryota
ENOG4111KZ9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000000954

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y3V2

Identification of Orthologs from Complete Genome Data

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OMAi
CGPHEWE

Database of Orthologous Groups

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OrthoDBi
1437243at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y3V2

TreeFam database of animal gene trees

More...
TreeFami
TF324344

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006575 RWD-domain
IPR038840 RWDD3
IPR016135 UBQ-conjugating_enzyme/RWD

The PANTHER Classification System

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PANTHERi
PTHR15628 PTHR15628, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05773 RWD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00591 RWD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54495 SSF54495, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50908 RWD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y3V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEPVQEELS VLAAIFCRPH EWEVLSRSET DGTVFRIHTK AEGFMDVDIP
60 70 80 90 100
LELVFHLPVN YPSCLPGISI NSEQLTRAQC VTVKENLLEQ AESLLSEPMV
110 120 130 140 150
HELVLWIQQN LRHILSQPET GSGSEKCTFS TSTTMDDGLW ITLLHLDHMR
160 170 180 190 200
AKTKYVKIVE KWASDLRLTG RLMFMGKIIL ILLQGDRNNL KEYLILQKTS
210 220 230 240 250
KVDVDSSGKK CKEKMISVLF ETKVQTEHKR FLAFEVKEYS ALDELQKEFE
260
TAGLKKLFSE FVLALVK
Length:267
Mass (Da):30,543
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00F6892F29A57CA7
GO
Isoform 2 (identifier: Q9Y3V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-195: EYLI → VPKS
     196-267: Missing.

Show »
Length:195
Mass (Da):22,154
Checksum:iD46523537F9E2BD9
GO
Isoform 3 (identifier: Q9Y3V2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MAEPVQEELSVLAAIFCRPHEWEVLSRS → MFLSCGSLHQRGP
     177-267: KIILILLQGD...FSEFVLALVK → VLDSSENLQSRCGLKWKEMQREND

Show »
Length:185
Mass (Da):21,062
Checksum:iC048C80A699BC846
GO
Isoform 4 (identifier: Q9Y3V2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-267: KIILILLQGD...FSEFVLALVK → VLDSSENLQSRCGLKWKEMQREND

Show »
Length:200
Mass (Da):22,857
Checksum:i944D99E6BA3AE41C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79Q → R in CAG38524 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03442047V → A4 PublicationsCorresponds to variant dbSNP:rs259358Ensembl.1
Natural variantiVAR_02434686N → K4 PublicationsCorresponds to variant dbSNP:rs2296308Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0354111 – 28MAEPV…VLSRS → MFLSCGSLHQRGP in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_035412177 – 267KIILI…LALVK → VLDSSENLQSRCGLKWKEMQ REND in isoform 3 and isoform 4. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_034176192 – 195EYLI → VPKS in isoform 2. 4 Publications4
Alternative sequenceiVSP_034177196 – 267Missing in isoform 2. 4 PublicationsAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL050062 mRNA Translation: CAB43254.2
AK292665 mRNA Translation: BAF85354.1
AK292699 mRNA Translation: BAF85388.1
CR533493 mRNA Translation: CAG38524.1
AC092802 Genomic DNA No translation available.
BC010936 mRNA No translation available.
BC125142 mRNA Translation: AAI25143.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41357.1 [Q9Y3V2-1]
CCDS44177.1 [Q9Y3V2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001121614.1, NM_001128142.1
NP_001265176.1, NM_001278247.1
NP_001265177.1, NM_001278248.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263893; ENSP00000263893; ENSG00000122481 [Q9Y3V2-2]
ENST00000370202; ENSP00000359221; ENSG00000122481 [Q9Y3V2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25950

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:25950

UCSC genome browser

More...
UCSCi
uc001drf.5 human [Q9Y3V2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050062 mRNA Translation: CAB43254.2
AK292665 mRNA Translation: BAF85354.1
AK292699 mRNA Translation: BAF85388.1
CR533493 mRNA Translation: CAG38524.1
AC092802 Genomic DNA No translation available.
BC010936 mRNA No translation available.
BC125142 mRNA Translation: AAI25143.1
CCDSiCCDS41357.1 [Q9Y3V2-1]
CCDS44177.1 [Q9Y3V2-2]
RefSeqiNP_001121614.1, NM_001128142.1
NP_001265176.1, NM_001278247.1
NP_001265177.1, NM_001278248.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBKNMR-A1-121[»]
4Y1LX-ray2.70C2-113[»]
SMRiQ9Y3V2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117445, 6 interactors
IntActiQ9Y3V2, 4 interactors
STRINGi9606.ENSP00000359221

PTM databases

iPTMnetiQ9Y3V2
PhosphoSitePlusiQ9Y3V2

Polymorphism and mutation databases

BioMutaiRWDD3
DMDMi296453018

Proteomic databases

EPDiQ9Y3V2
PaxDbiQ9Y3V2
PeptideAtlasiQ9Y3V2
PRIDEiQ9Y3V2
ProteomicsDBi86080
86081 [Q9Y3V2-2]
86082 [Q9Y3V2-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25950
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263893; ENSP00000263893; ENSG00000122481 [Q9Y3V2-2]
ENST00000370202; ENSP00000359221; ENSG00000122481 [Q9Y3V2-1]
GeneIDi25950
KEGGihsa:25950
UCSCiuc001drf.5 human [Q9Y3V2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25950
DisGeNETi25950

GeneCards: human genes, protein and diseases

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GeneCardsi
RWDD3
HGNCiHGNC:21393 RWDD3
MIMi615875 gene
neXtProtiNX_Q9Y3V2
OpenTargetsiENSG00000122481
PharmGKBiPA134974302

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IGD3 Eukaryota
ENOG4111KZ9 LUCA
GeneTreeiENSGT00390000000954
InParanoidiQ9Y3V2
OMAiCGPHEWE
OrthoDBi1437243at2759
PhylomeDBiQ9Y3V2
TreeFamiTF324344

Enzyme and pathway databases

ReactomeiR-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SIGNORiQ9Y3V2

Miscellaneous databases

EvolutionaryTraceiQ9Y3V2

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RWDD3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25950

Protein Ontology

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PROi
PR:Q9Y3V2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000122481 Expressed in 91 organ(s), highest expression level in caudate nucleus
GenevisibleiQ9Y3V2 HS

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR006575 RWD-domain
IPR038840 RWDD3
IPR016135 UBQ-conjugating_enzyme/RWD
PANTHERiPTHR15628 PTHR15628, 1 hit
PfamiView protein in Pfam
PF05773 RWD, 1 hit
SMARTiView protein in SMART
SM00591 RWD, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50908 RWD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRWDD3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3V2
Secondary accession number(s): A6NP44
, A8K9F0, C9J9L7, C9JI45, Q08AJ7, Q6FID3, Q9BX35
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 136 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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