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Entry version 157 (16 Oct 2019)
Sequence version 2 (10 May 2005)
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Protein

Doublesex- and mab-3-related transcription factor 1

Gene

DMRT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi72 – 118DMPROSITE-ProRule annotationAdd BLAST47

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Sexual differentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor 1
Alternative name(s):
DM domain expressed in testis protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMRT1
Synonyms:DMT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2934 DMRT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602424 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5R6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Testicular germ cell tumor (TGCT)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma.
Related information in OMIM
46,XY sex reversal 4 (SRXY4)3 Publications
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients display complete or partial gonadal dysgenesis and a chromosome 9p deletion.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
1761

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DMRT1

MalaCards human disease database

More...
MalaCardsi
DMRT1
MIMi154230 phenotype
273300 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000137090

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
242 46,XY complete gonadal dysgenesis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27381

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y5R6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DMRT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
83305820

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002070421 – 373Doublesex- and mab-3-related transcription factor 1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei339PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y5R6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y5R6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y5R6

PeptideAtlas

More...
PeptideAtlasi
Q9Y5R6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y5R6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86485 [Q9Y5R6-1]
86486 [Q9Y5R6-2]
86487 [Q9Y5R6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y5R6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y5R6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific. Expressed in prostate cancer (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the genital ridges of six-week-old male embryos. Becomes confined to the forming seminiferous tubules (probably Sertoli cells) at seven weeks. Not detected in female embryos.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137090 Expressed in 19 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y5R6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y5R6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027850

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-7963304,EBI-7963304

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108101, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-58084N

Protein interaction database and analysis system

More...
IntActi
Q9Y5R6, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9Y5R6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371711

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y5R6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi322 – 347Pro/Ser-richAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DMRT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3815 Eukaryota
ENOG410XSK9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156489

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059585

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y5R6

KEGG Orthology (KO)

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KOi
K19488

Identification of Orthologs from Complete Genome Data

More...
OMAi
AGNQWQM

Database of Orthologous Groups

More...
OrthoDBi
1209937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y5R6

TreeFam database of animal gene trees

More...
TreeFami
TF317837

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1040.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001275 DM_DNA-bd
IPR036407 DM_DNA-bd_sf
IPR026607 DMRT/dsx/mab-3
IPR022114 DMRT1-like

The PANTHER Classification System

More...
PANTHERi
PTHR12322 PTHR12322, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00751 DM, 1 hit
PF12374 Dmrt1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00301 DM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82927 SSF82927, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS40000 DM_1, 1 hit
PS50809 DM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5R6-1) [UniParc]FASTAAdd to basket
Also known as: DMRT1a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPNDEAFSKP STPSEAPHAP GVPPQGRAGG FGKASGALVG AASGSSAGGS
60 70 80 90 100
SRGGGSGSGA SDLGAGSKKS PRLPKCARCR NHGYASPLKG HKRFCMWRDC
110 120 130 140 150
QCKKCNLIAE RQRVMAAQVA LRRQQAQEEE LGISHPIPLP SAAELLVKRE
160 170 180 190 200
NNGSNPCLMT ECSGTSQPPP ASVPTTAASE GRMVIQDIPA VTSRGHVENT
210 220 230 240 250
PDLVSDSTYY SSFYQPSLFP YYNNLYNCPQ YSMALAADSA SGEVGNPLGG
260 270 280 290 300
SPVKNSLRGL PGPYVPGQTG NQWQMKNMEN RHAMSSQYRM HSYYPPPSYL
310 320 330 340 350
GQSVPQFFTF EDAPSYPEAR ASVFSPPSSQ DSGLVSLSSS SPISNKSTKA
360 370
VLECEPASEP SSFTVTPVIE EDE
Length:373
Mass (Da):39,473
Last modified:May 10, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23348B2C4A4733A1
GO
Isoform 2 (identifier: Q9Y5R6-2) [UniParc]FASTAAdd to basket
Also known as: DMRT1b

The sequence of this isoform differs from the canonical sequence as follows:
     275-275: M → V
     276-373: Missing.

Show »
Length:275
Mass (Da):28,690
Checksum:iE5ED8B07861609D9
GO
Isoform 3 (identifier: Q9Y5R6-3) [UniParc]FASTAAdd to basket
Also known as: DMRT1c

The sequence of this isoform differs from the canonical sequence as follows:
     120-175: ALRRQQAQEE...SQPPPASVPT → GAGVREPGFS...QAILLPQPPK
     176-373: Missing.

Show »
Length:175
Mass (Da):18,325
Checksum:i9CFD6F98F5F9B54C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BN61H3BN61_HUMAN
Doublesex- and mab-3-related transc...
DMRT1
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00995445S → T3 PublicationsCorresponds to variant dbSNP:rs3739583Ensembl.1
Natural variantiVAR_009955221Y → S1 Publication1
Natural variantiVAR_009956281R → S1 Publication1
Natural variantiVAR_009957295P → L1 PublicationCorresponds to variant dbSNP:rs902482318Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042959120 – 175ALRRQ…ASVPT → GAGVREPGFSLSFFFFFFFF RWSLARLPRLQCSGAILAHC NSASRVQAILLPQPPK in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_042960176 – 373Missing in isoform 3. 1 PublicationAdd BLAST198
Alternative sequenceiVSP_042961275M → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_042962276 – 373Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF130728 mRNA Translation: AAD40474.1
AL162131 mRNA Translation: CAB82427.1
AY442914 mRNA Translation: AAR89619.1
AY442915 mRNA Translation: AAR89620.1
AK313594 mRNA Translation: BAG36360.1
AJ276801 mRNA Translation: CAB82851.1
AL136365 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58820.1
BC040847 mRNA Translation: AAH40847.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6442.1 [Q9Y5R6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_068770.2, NM_021951.2 [Q9Y5R6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000382276; ENSP00000371711; ENSG00000137090 [Q9Y5R6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1761

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1761

UCSC genome browser

More...
UCSCi
uc003zgv.5 human [Q9Y5R6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130728 mRNA Translation: AAD40474.1
AL162131 mRNA Translation: CAB82427.1
AY442914 mRNA Translation: AAR89619.1
AY442915 mRNA Translation: AAR89620.1
AK313594 mRNA Translation: BAG36360.1
AJ276801 mRNA Translation: CAB82851.1
AL136365 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58820.1
BC040847 mRNA Translation: AAH40847.1
CCDSiCCDS6442.1 [Q9Y5R6-1]
RefSeqiNP_068770.2, NM_021951.2 [Q9Y5R6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YJ0X-ray3.81A/B/C70-131[»]
SMRiQ9Y5R6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108101, 2 interactors
DIPiDIP-58084N
IntActiQ9Y5R6, 1 interactor
MINTiQ9Y5R6
STRINGi9606.ENSP00000371711

PTM databases

iPTMnetiQ9Y5R6
PhosphoSitePlusiQ9Y5R6

Polymorphism and mutation databases

BioMutaiDMRT1
DMDMi83305820

Proteomic databases

jPOSTiQ9Y5R6
MassIVEiQ9Y5R6
PaxDbiQ9Y5R6
PeptideAtlasiQ9Y5R6
PRIDEiQ9Y5R6
ProteomicsDBi86485 [Q9Y5R6-1]
86486 [Q9Y5R6-2]
86487 [Q9Y5R6-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1761

Genome annotation databases

EnsembliENST00000382276; ENSP00000371711; ENSG00000137090 [Q9Y5R6-1]
GeneIDi1761
KEGGihsa:1761
UCSCiuc003zgv.5 human [Q9Y5R6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1761
DisGeNETi1761

GeneCards: human genes, protein and diseases

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GeneCardsi
DMRT1
GeneReviewsiDMRT1
HGNCiHGNC:2934 DMRT1
HPAiHPA027850
MalaCardsiDMRT1
MIMi154230 phenotype
273300 phenotype
602424 gene
neXtProtiNX_Q9Y5R6
OpenTargetsiENSG00000137090
Orphaneti242 46,XY complete gonadal dysgenesis
PharmGKBiPA27381

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3815 Eukaryota
ENOG410XSK9 LUCA
GeneTreeiENSGT00940000156489
HOGENOMiHOG000059585
InParanoidiQ9Y5R6
KOiK19488
OMAiAGNQWQM
OrthoDBi1209937at2759
PhylomeDBiQ9Y5R6
TreeFamiTF317837

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DMRT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1761
PharosiQ9Y5R6

Protein Ontology

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PROi
PR:Q9Y5R6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000137090 Expressed in 19 organ(s), highest expression level in female gonad
ExpressionAtlasiQ9Y5R6 baseline and differential
GenevisibleiQ9Y5R6 HS

Family and domain databases

Gene3Di4.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR001275 DM_DNA-bd
IPR036407 DM_DNA-bd_sf
IPR026607 DMRT/dsx/mab-3
IPR022114 DMRT1-like
PANTHERiPTHR12322 PTHR12322, 1 hit
PfamiView protein in Pfam
PF00751 DM, 1 hit
PF12374 Dmrt1, 1 hit
SMARTiView protein in SMART
SM00301 DM, 1 hit
SUPFAMiSSF82927 SSF82927, 1 hit
PROSITEiView protein in PROSITE
PS40000 DM_1, 1 hit
PS50809 DM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMRT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5R6
Secondary accession number(s): B2R913
, Q6T1H8, Q6T1H9, Q8IW77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2005
Last modified: October 16, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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