UniProtKB - Q9Y5U2 (TSSC4_HUMAN)
Protein
Protein TSSC4
Gene
TSSC4
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein TSSC4Alternative name(s): Tumor-suppressing STF cDNA 4 protein Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein |
Gene namesi | Name:TSSC4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12386 TSSC4 |
MIMi | 603852 gene |
neXtProti | NX_Q9Y5U2 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000184281 |
PharmGKBi | PA37054 |
Miscellaneous databases
Pharosi | Q9Y5U2 |
Polymorphism and mutation databases
BioMutai | TSSC4 |
DMDMi | 296453006 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076360 | 1 – 329 | Protein TSSC4Add BLAST | 329 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | PhosphoserineBy similarity | 1 | |
Modified residuei | 67 | PhosphoserineBy similarity | 1 | |
Modified residuei | 86 | PhosphoserineCombined sources | 1 | |
Modified residuei | 132 | PhosphoserineCombined sources | 1 | |
Modified residuei | 143 | PhosphoserineCombined sources | 1 | |
Modified residuei | 146 | PhosphoserineCombined sources | 1 | |
Modified residuei | 217 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 265 | PhosphoserineCombined sources | 1 | |
Modified residuei | 321 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y5U2 |
jPOSTi | Q9Y5U2 |
MassIVEi | Q9Y5U2 |
PaxDbi | Q9Y5U2 |
PeptideAtlasi | Q9Y5U2 |
PRIDEi | Q9Y5U2 |
ProteomicsDBi | 86505 [Q9Y5U2-1] 86506 [Q9Y5U2-2] |
PTM databases
iPTMneti | Q9Y5U2 |
PhosphoSitePlusi | Q9Y5U2 |
Expressioni
Tissue specificityi
Expressed in fetal brain, lung, liver and kidney. Widely expressed in adult tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000184281 Expressed in 187 organ(s), highest expression level in left testis |
ExpressionAtlasi | Q9Y5U2 baseline and differential |
Genevisiblei | Q9Y5U2 HS |
Organism-specific databases
HPAi | HPA041801 HPA058763 |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 115388, 100 interactors |
IntActi | Q9Y5U2, 70 interactors |
MINTi | Q9Y5U2 |
STRINGi | 9606.ENSP00000331087 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TSSC4 family.Curated
Phylogenomic databases
eggNOGi | ENOG410IIC0 Eukaryota ENOG41120VA LUCA |
GeneTreei | ENSGT00390000011846 |
HOGENOMi | HOG000154697 |
InParanoidi | Q9Y5U2 |
OMAi | PEAEEWS |
OrthoDBi | 1538986at2759 |
PhylomeDBi | Q9Y5U2 |
TreeFami | TF335741 |
Family and domain databases
InterProi | View protein in InterPro IPR029338 TSSC4 |
PANTHERi | PTHR13445 PTHR13445, 1 hit |
Pfami | View protein in Pfam PF15264 TSSC4, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y5U2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEAGTGEPS PSVEGEHGTE YDTLPSDTVS LSDSDSDLSL PGGAEVEALS
60 70 80 90 100
PMGLPGEEDS GPDEPPSPPS GLLPATVQPF HLRGMSSTFS QRSRDIFDCL
110 120 130 140 150
EGAARRAPSS VAHTSMSDNG GFKRPLAPSG RSPVEGLGRA HRSPASPRVP
160 170 180 190 200
PVPDYVAHPE RWTKYSLEDV TEVSEQSNQA TALAFLGSQS LAAPTDCVSS
210 220 230 240 250
FNQDPSSCGE GRVIFTKPVR GVEARHERKR VLGKVGEPGR GGLGNPATDR
260 270 280 290 300
GEGPVELAHL AGPGSPEAEE WGSHHGGLQE VEALSGSVHS GSVPGLPPVE
310 320
TVGFHGSRKR SRDHFRNKSS SPEDPGAEV
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA6NCC9 | A6NCC9_HUMAN | Protein TSSC4 | TSSC4 | 127 | Annotation score: | ||
C9JHT9 | C9JHT9_HUMAN | Protein TSSC4 | TSSC4 | 203 | Annotation score: | ||
C9JDU0 | C9JDU0_HUMAN | Protein TSSC4 | TSSC4 | 112 | Annotation score: | ||
E9PME3 | E9PME3_HUMAN | Protein TSSC4 | TSSC4 | 191 | Annotation score: | ||
E9PL88 | E9PL88_HUMAN | Protein TSSC4 | TSSC4 | 110 | Annotation score: | ||
C9JJV1 | C9JJV1_HUMAN | Protein TSSC4 | TSSC4 | 207 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 72 | L → F in AAD23579 (PubMed:10072438).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057826 | 17 | H → P. Corresponds to variant dbSNP:rs2234278Ensembl. | 1 | |
Natural variantiVAR_060194 | 124 | R → Q. Corresponds to variant dbSNP:rs1008265Ensembl. | 1 | |
Natural variantiVAR_057827 | 230 | R → S. Corresponds to variant dbSNP:rs2234280Ensembl. | 1 | |
Natural variantiVAR_057828 | 262 | G → R. Corresponds to variant dbSNP:rs2234281Ensembl. | 1 | |
Natural variantiVAR_063128 | 274 | H → P2 PublicationsCorresponds to variant dbSNP:rs2234283Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016561 | 8 – 71 | Missing in isoform 2. 1 PublicationAdd BLAST | 64 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF125568 mRNA Translation: AAD23579.1 AC124057 Genomic DNA No translation available. BC006091 mRNA Translation: AAH06091.1 BC050616 mRNA Translation: AAH50616.1 |
CCDSi | CCDS73241.1 [Q9Y5U2-2] CCDS7735.1 [Q9Y5U2-1] |
RefSeqi | NP_001284587.1, NM_001297658.1 [Q9Y5U2-1] NP_001284588.1, NM_001297659.1 [Q9Y5U2-1] NP_001284589.1, NM_001297660.1 [Q9Y5U2-1] NP_001284590.1, NM_001297661.1 [Q9Y5U2-2] NP_005697.2, NM_005706.3 [Q9Y5U2-1] XP_006718181.1, XM_006718118.2 [Q9Y5U2-1] XP_011518132.1, XM_011519830.2 [Q9Y5U2-1] |
Genome annotation databases
Ensembli | ENST00000333256; ENSP00000331087; ENSG00000184281 [Q9Y5U2-1] ENST00000380996; ENSP00000370384; ENSG00000184281 [Q9Y5U2-2] ENST00000451491; ENSP00000411224; ENSG00000184281 [Q9Y5U2-1] |
GeneIDi | 10078 |
KEGGi | hsa:10078 |
UCSCi | uc001lwi.4 human [Q9Y5U2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF125568 mRNA Translation: AAD23579.1 AC124057 Genomic DNA No translation available. BC006091 mRNA Translation: AAH06091.1 BC050616 mRNA Translation: AAH50616.1 |
CCDSi | CCDS73241.1 [Q9Y5U2-2] CCDS7735.1 [Q9Y5U2-1] |
RefSeqi | NP_001284587.1, NM_001297658.1 [Q9Y5U2-1] NP_001284588.1, NM_001297659.1 [Q9Y5U2-1] NP_001284589.1, NM_001297660.1 [Q9Y5U2-1] NP_001284590.1, NM_001297661.1 [Q9Y5U2-2] NP_005697.2, NM_005706.3 [Q9Y5U2-1] XP_006718181.1, XM_006718118.2 [Q9Y5U2-1] XP_011518132.1, XM_011519830.2 [Q9Y5U2-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 115388, 100 interactors |
IntActi | Q9Y5U2, 70 interactors |
MINTi | Q9Y5U2 |
STRINGi | 9606.ENSP00000331087 |
PTM databases
iPTMneti | Q9Y5U2 |
PhosphoSitePlusi | Q9Y5U2 |
Polymorphism and mutation databases
BioMutai | TSSC4 |
DMDMi | 296453006 |
Proteomic databases
EPDi | Q9Y5U2 |
jPOSTi | Q9Y5U2 |
MassIVEi | Q9Y5U2 |
PaxDbi | Q9Y5U2 |
PeptideAtlasi | Q9Y5U2 |
PRIDEi | Q9Y5U2 |
ProteomicsDBi | 86505 [Q9Y5U2-1] 86506 [Q9Y5U2-2] |
Protocols and materials databases
DNASUi | 10078 |
Genome annotation databases
Ensembli | ENST00000333256; ENSP00000331087; ENSG00000184281 [Q9Y5U2-1] ENST00000380996; ENSP00000370384; ENSG00000184281 [Q9Y5U2-2] ENST00000451491; ENSP00000411224; ENSG00000184281 [Q9Y5U2-1] |
GeneIDi | 10078 |
KEGGi | hsa:10078 |
UCSCi | uc001lwi.4 human [Q9Y5U2-1] |
Organism-specific databases
CTDi | 10078 |
GeneCardsi | TSSC4 |
HGNCi | HGNC:12386 TSSC4 |
HPAi | HPA041801 HPA058763 |
MIMi | 603852 gene |
neXtProti | NX_Q9Y5U2 |
OpenTargetsi | ENSG00000184281 |
PharmGKBi | PA37054 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IIC0 Eukaryota ENOG41120VA LUCA |
GeneTreei | ENSGT00390000011846 |
HOGENOMi | HOG000154697 |
InParanoidi | Q9Y5U2 |
OMAi | PEAEEWS |
OrthoDBi | 1538986at2759 |
PhylomeDBi | Q9Y5U2 |
TreeFami | TF335741 |
Miscellaneous databases
ChiTaRSi | TSSC4 human |
GenomeRNAii | 10078 |
Pharosi | Q9Y5U2 |
PROi | PR:Q9Y5U2 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184281 Expressed in 187 organ(s), highest expression level in left testis |
ExpressionAtlasi | Q9Y5U2 baseline and differential |
Genevisiblei | Q9Y5U2 HS |
Family and domain databases
InterProi | View protein in InterPro IPR029338 TSSC4 |
PANTHERi | PTHR13445 PTHR13445, 1 hit |
Pfami | View protein in Pfam PF15264 TSSC4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSSC4_HUMAN | |
Accessioni | Q9Y5U2Primary (citable) accession number: Q9Y5U2 Secondary accession number(s): C9JS66, Q86VL2, Q9BRS6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | May 18, 2010 | |
Last modified: | October 16, 2019 | |
This is version 130 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot