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Entry version 158 (18 Sep 2019)
Sequence version 2 (03 May 2011)
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Protein

Peroxisomal membrane protein PEX16

Gene

PEX16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeroxisome biogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9603798 Class I peroxisomal membrane protein import

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.17.1.2 the integral membrane peroxisomal protein importer-2 (ppi2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisomal membrane protein PEX16
Alternative name(s):
Peroxin-16
Peroxisomal biogenesis factor 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PEX16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8857 PEX16

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603360 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y5Y5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 84CytoplasmicSequence analysisAdd BLAST84
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 110PeroxisomalSequence analysis5
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 336CytoplasmicSequence analysisAdd BLAST205

Keywords - Cellular componenti

Membrane, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Peroxisome biogenesis disorder complementation group 9 (PBD-CG9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS).
Related information in OMIM
Peroxisome biogenesis disorder 8A (PBD8A)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA fatal peroxisome biogenesis disorder belonging to the Zellweger disease spectrum and clinically characterized by severe neurologic dysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities, liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular and skeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals with the classic form of the disease (classic Zellweger syndrome) die within the first year of life.
Related information in OMIM
Peroxisome biogenesis disorder 8B (PBD8B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA relatively mild peroxisome biogenesis disorder. Affected individuals manifest lower limb spasticity and ataxia resulting in wheelchair dependence. Other features include optic atrophy, cataracts, dysarthria, dysphagia, constipation, and a peripheral demyelinating motor and sensory neuropathy. Cognition is relatively preserved. Biochemical abnormalities are mild and include increased very-long-chain fatty acids (VLCFA), increased bile acid intermediates, and increased branched chain fatty acids. Phytanic acid alpha-oxidation, pristanic acid beta-oxidation, and red cell plasmalogen are normal.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069208252Missing in PBD8B. 1 Publication1
Natural variantiVAR_069209289P → T in PBD8B. 1 Publication1
Natural variantiVAR_069210331Y → C in PBD8B. 1 PublicationCorresponds to variant dbSNP:rs397514472Ensembl.1

Keywords - Diseasei

Disease mutation, Peroxisome biogenesis disorder, Zellweger syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
9409

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
PEX16

MalaCards human disease database

More...
MalaCardsi
PEX16
MIMi614876 phenotype
614877 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000121680

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
772 Infantile Refsum disease
44 Neonatal adrenoleukodystrophy
912 Zellweger syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33199

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y5Y5

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3774297

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PEX16

Domain mapping of disease mutations (DMDM)

More...
DMDMi
332278135

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000583301 – 336Peroxisomal membrane protein PEX16Add BLAST336

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y5Y5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y5Y5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9Y5Y5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y5Y5

PeptideAtlas

More...
PeptideAtlasi
Q9Y5Y5

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y5Y5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86541 [Q9Y5Y5-1]
86542 [Q9Y5Y5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y5Y5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y5Y5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121680 Expressed in 222 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y5Y5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y5Y5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043286

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PEX19.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P4085519EBI-981985,EBI-594747

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114804, 14 interactors

Protein interaction database and analysis system

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IntActi
Q9Y5Y5, 21 interactors

Molecular INTeraction database

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MINTi
Q9Y5Y5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000241041

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 81Required for peroxisomal location1 PublicationAdd BLAST16
Regioni221 – 336Interaction with PEX191 PublicationAdd BLAST116

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxin-16 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4546 Eukaryota
ENOG4111GEA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017790

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008062

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y5Y5

KEGG Orthology (KO)

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KOi
K13335

Identification of Orthologs from Complete Genome Data

More...
OMAi
STYFYLW

Database of Orthologous Groups

More...
OrthoDBi
883624at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324139

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013919 Pex16

The PANTHER Classification System

More...
PANTHERi
PTHR13299 PTHR13299, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08610 Pex16, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y5Y5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKLRLLGLR YQEYVTRHPA ATAQLETAVR GFSYLLAGRF ADSHELSELV
60 70 80 90 100
YSASNLLVLL NDGILRKELR KKLPVSLSQQ KLLTWLSVLE CVEVFMEMGA
110 120 130 140 150
AKVWGEVGRW LVIALVQLAK AVLRMLLLLW FKAGLQTSPP IVPLDRETQA
160 170 180 190 200
QPPDGDHSPG NHEQSYVGKR SNRVVRTLQN TPSLHSRHWG APQQREGRQQ
210 220 230 240 250
QHHEELSATP TPLGLQETIA EFLYIARPLL HLLSLGLWGQ RSWKPWLLAG
260 270 280 290 300
VVDVTSLSLL SDRKGLTRRE RRELRRRTIL LLYYLLRSPF YDRFSEARIL
310 320 330
FLLQLLADHV PGVGLVTRPL MDYLPTWQKI YFYSWG
Length:336
Mass (Da):38,629
Last modified:May 3, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57243AEE0B165C59
GO
Isoform 2 (identifier: Q9Y5Y5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-336: RPLMDYLPTWQKIYFYSWG → TSQRAASPCLPARPHTQPWSPPAFLPGHP

Show »
Length:346
Mass (Da):39,270
Checksum:i2C7FE986CF33B64B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLS4E9PLS4_HUMAN
Peroxisomal membrane protein PEX16
PEX16
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMM3E9PMM3_HUMAN
Peroxisomal membrane protein PEX16
PEX16
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PP98E9PP98_HUMAN
Peroxisomal membrane protein PEX16
PEX16
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQW0E9PQW0_HUMAN
Peroxisomal membrane protein PEX16
PEX16
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMS3E9PMS3_HUMAN
Peroxisomal membrane protein PEX16
PEX16
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSC6E9PSC6_HUMAN
Peroxisomal membrane protein PEX16
PEX16
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti107V → L in AAH00467 (PubMed:15489334).Curated1
Sequence conflicti125M → I in AAH00467 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051272103V → M. Corresponds to variant dbSNP:rs11553094EnsemblClinVar.1
Natural variantiVAR_061841116V → I3 PublicationsCorresponds to variant dbSNP:rs10742772Ensembl.1
Natural variantiVAR_069208252Missing in PBD8B. 1 Publication1
Natural variantiVAR_034145254V → L. Corresponds to variant dbSNP:rs35214605EnsemblClinVar.1
Natural variantiVAR_069209289P → T in PBD8B. 1 Publication1
Natural variantiVAR_069210331Y → C in PBD8B. 1 PublicationCorresponds to variant dbSNP:rs397514472Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036593318 – 336RPLMD…FYSWG → TSQRAASPCLPARPHTQPWS PPAFLPGHP in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB016531 mRNA Translation: BAA88826.1
AF118240 mRNA Translation: AAD22466.1
AC068385 Genomic DNA No translation available.
BC004356 mRNA Translation: AAH04356.1
BC000467 mRNA Translation: AAH00467.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31472.1 [Q9Y5Y5-1]
CCDS7917.1 [Q9Y5Y5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_004804.1, NM_004813.2
NP_476515.1, NM_057174.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000241041; ENSP00000241041; ENSG00000121680 [Q9Y5Y5-2]
ENST00000378750; ENSP00000368024; ENSG00000121680 [Q9Y5Y5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9409

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9409

UCSC genome browser

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UCSCi
uc001nbt.4 human [Q9Y5Y5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016531 mRNA Translation: BAA88826.1
AF118240 mRNA Translation: AAD22466.1
AC068385 Genomic DNA No translation available.
BC004356 mRNA Translation: AAH04356.1
BC000467 mRNA Translation: AAH00467.1
CCDSiCCDS31472.1 [Q9Y5Y5-1]
CCDS7917.1 [Q9Y5Y5-2]
RefSeqiNP_004804.1, NM_004813.2
NP_476515.1, NM_057174.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi114804, 14 interactors
IntActiQ9Y5Y5, 21 interactors
MINTiQ9Y5Y5
STRINGi9606.ENSP00000241041

Chemistry databases

ChEMBLiCHEMBL3774297

Protein family/group databases

TCDBi9.A.17.1.2 the integral membrane peroxisomal protein importer-2 (ppi2) family

PTM databases

iPTMnetiQ9Y5Y5
PhosphoSitePlusiQ9Y5Y5

Polymorphism and mutation databases

BioMutaiPEX16
DMDMi332278135

Proteomic databases

EPDiQ9Y5Y5
jPOSTiQ9Y5Y5
MassIVEiQ9Y5Y5
PaxDbiQ9Y5Y5
PeptideAtlasiQ9Y5Y5
PRIDEiQ9Y5Y5
ProteomicsDBi86541 [Q9Y5Y5-1]
86542 [Q9Y5Y5-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9409

Genome annotation databases

EnsembliENST00000241041; ENSP00000241041; ENSG00000121680 [Q9Y5Y5-2]
ENST00000378750; ENSP00000368024; ENSG00000121680 [Q9Y5Y5-1]
GeneIDi9409
KEGGihsa:9409
UCSCiuc001nbt.4 human [Q9Y5Y5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9409
DisGeNETi9409

GeneCards: human genes, protein and diseases

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GeneCardsi
PEX16
GeneReviewsiPEX16
HGNCiHGNC:8857 PEX16
HPAiHPA043286
MalaCardsiPEX16
MIMi603360 gene
614876 phenotype
614877 phenotype
neXtProtiNX_Q9Y5Y5
OpenTargetsiENSG00000121680
Orphaneti772 Infantile Refsum disease
44 Neonatal adrenoleukodystrophy
912 Zellweger syndrome
PharmGKBiPA33199

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4546 Eukaryota
ENOG4111GEA LUCA
GeneTreeiENSGT00390000017790
HOGENOMiHOG000008062
InParanoidiQ9Y5Y5
KOiK13335
OMAiSTYFYLW
OrthoDBi883624at2759
TreeFamiTF324139

Enzyme and pathway databases

ReactomeiR-HSA-9603798 Class I peroxisomal membrane protein import

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PEX16 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PEX16

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9409
PharosiQ9Y5Y5

Protein Ontology

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PROi
PR:Q9Y5Y5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000121680 Expressed in 222 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ9Y5Y5 baseline and differential
GenevisibleiQ9Y5Y5 HS

Family and domain databases

InterProiView protein in InterPro
IPR013919 Pex16
PANTHERiPTHR13299 PTHR13299, 1 hit
PfamiView protein in Pfam
PF08610 Pex16, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEX16_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y5Y5
Secondary accession number(s): Q9BWB9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 3, 2011
Last modified: September 18, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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