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Entry version 168 (13 Nov 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Transforming acidic coiled-coil-containing protein 3

Gene

TACC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-9604323 Negative regulation of NOTCH4 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transforming acidic coiled-coil-containing protein 3
Alternative name(s):
ERIC-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TACC3
Synonyms:ERIC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11524 TACC3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605303 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6A5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi558S → A: Disrupts localization to mitotic spindle and impairs recruitment of clathrin to mitotic spindle. 1 Publication1
Mutagenesisi566 – 567LL → AA: Impairs localization to mitotic spindle. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
10460

MalaCards human disease database

More...
MalaCardsi
TACC3

Open Targets

More...
OpenTargetsi
ENSG00000013810

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
251579 Giant cell glioblastoma
251576 Gliosarcoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36301

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y6A5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TACC3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13431939

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001799902 – 838Transforming acidic coiled-coil-containing protein 3Add BLAST837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei177PhosphoserineCombined sources1
Modified residuei250PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei402PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei558Phosphoserine; by AURKACombined sources1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y6A5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y6A5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y6A5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y6A5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6A5

PeptideAtlas

More...
PeptideAtlasi
Q9Y6A5

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6A5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86642

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6A5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6A5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in various cancer cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000013810 Expressed in 147 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6A5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6A5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010111
HPA005781
HPA006050
HPA022039

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with microtubules.

Interacts with CKAP5 independently of clathrin.

Interacts with CKAP5 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; TACC3 (phosphorylated at Ser-558 by AURKA) and CLTC are proposed to form a composite microtubule interaction surface (PubMed:21297582, PubMed:23918938, PubMed:25596274).

Interacts with CCDC100/CEP120. The coiled coil C-terminal region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity).

Interacts with GCN5L2 and PCAF (PubMed:14767476).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115723, 87 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y6A5

Protein interaction database and analysis system

More...
IntActi
Q9Y6A5, 73 interactors

Molecular INTeraction database

More...
MINTi
Q9Y6A5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326550

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1838
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y6A5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni522 – 577Necessary but not sufficient for spindle localization1 PublicationAdd BLAST56
Regioni594 – 838Necessary but not sufficient for spindle localization1 PublicationAdd BLAST245

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili637 – 837Sequence analysisAdd BLAST201

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi155 – 160Poly-Ser6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TACC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIVK Eukaryota
ENOG410YMFS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158858

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294059

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6A5

KEGG Orthology (KO)

More...
KOi
K14283

Identification of Orthologs from Complete Genome Data

More...
OMAi
RITQEGQ

Database of Orthologous Groups

More...
OrthoDBi
669540at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6A5

TreeFam database of animal gene trees

More...
TreeFami
TF333149

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039915 TACC
IPR007707 TACC_C

The PANTHER Classification System

More...
PANTHERi
PTHR13924 PTHR13924, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05010 TACC_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9Y6A5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLQVLNDKN VSNEKNTENC DFLFSPPEVT GRSSVLRVSQ KENVPPKNLA
60 70 80 90 100
KAMKVTFQTP LRDPQTHRIL SPSMASKLEA PFTQDDTLGL ENSHPVWTQK
110 120 130 140 150
ENQQLIKEVD AKTTHGILQK PVEADTDLLG DASPAFGSGS SSESGPGALA
160 170 180 190 200
DLDCSSSSQS PGSSENQMVS PGKVSGSPEQ AVEENLSSYS LDRRVTPASE
210 220 230 240 250
TLEDPCRTES QHKAETPHGA EEECKAETPH GAEEECRHGG VCAPAAVATS
260 270 280 290 300
PPGAIPKEAC GGAPLQGLPG EALGCPAGVG TPVPADGTQT LTCAHTSAPE
310 320 330 340 350
STAPTNHLVA GRAMTLSPQE EVAAGQMASS SRSGPVKLEF DVSDGATSKR
360 370 380 390 400
APPPRRLGER SGLKPPLRKA AVRQQKAPQE VEEDDGRSGA GEDPPMPASR
410 420 430 440 450
GSYHLDWDKM DDPNFIPFGG DTKSGCSEAQ PPESPETRLG QPAAEQLHAG
460 470 480 490 500
PATEEPGPCL SQQLHSASAE DTPVVQLAAE TPTAESKERA LNSASTSLPT
510 520 530 540 550
SCPGSEPVPT HQQGQPALEL KEESFRDPAE VLGTGAEVDY LEQFGTSSFK
560 570 580 590 600
ESALRKQSLY LKFDPLLRDS PGRPVPVATE TSSMHGANET PSGRPREAKL
610 620 630 640 650
VEFDFLGALD IPVPGPPPGV PAPGGPPLST GPIVDLLQYS QKDLDAVVKA
660 670 680 690 700
TQEENRELRS RCEELHGKNL ELGKIMDRFE EVVYQAMEEV QKQKELSKAE
710 720 730 740 750
IQKVLKEKDQ LTTDLNSMEK SFSDLFKRFE KQKEVIEGYR KNEESLKKCV
760 770 780 790 800
EDYLARITQE GQRYQALKAH AEEKLQLANE EIAQVRSKAQ AEALALQASL
810 820 830
RKEQMRIQSL EKTVEQKTKE NEELTRICDD LISKMEKI
Length:838
Mass (Da):90,360
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07F056678096775E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JWI7C9JWI7_HUMAN
Transforming acidic coiled-coil-con...
TACC3
193Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMT0E7EMT0_HUMAN
Transforming acidic coiled-coil-con...
TACC3
272Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JA91C9JA91_HUMAN
Transforming acidic coiled-coil-con...
TACC3
230Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IX09Q8IX09_HUMAN
Erythropoietin induced cDNA-1 trans...
TACC3 ERIC-1s
145Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZT8A0A494BZT8_HUMAN
Transforming acidic coiled-coil-con...
TACC3
834Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC55F8WC55_HUMAN
Transforming acidic coiled-coil-con...
TACC3
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8F2H0Y8F2_HUMAN
Transforming acidic coiled-coil-con...
TACC3
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C117A0A494C117_HUMAN
Transforming acidic coiled-coil-con...
TACC3
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti342V → L in CAB53009 (PubMed:11298601).Curated1
Sequence conflicti406D → G in CAB53009 (PubMed:11298601).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053714143E → K. Corresponds to variant dbSNP:rs34205238Ensembl.1
Natural variantiVAR_053715275C → Y2 PublicationsCorresponds to variant dbSNP:rs17132047Ensembl.1
Natural variantiVAR_053716287G → S2 PublicationsCorresponds to variant dbSNP:rs1063743Ensembl.1
Natural variantiVAR_053717514G → E2 PublicationsCorresponds to variant dbSNP:rs17680881Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF093543 mRNA Translation: AAD25964.1
AJ243997 mRNA Translation: CAB53009.1
BC106071 mRNA Translation: AAI06072.1
BC111771 mRNA Translation: AAI11772.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3352.1

NCBI Reference Sequences

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RefSeqi
NP_006333.1, NM_006342.2
XP_016863142.1, XM_017007653.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000313288; ENSP00000326550; ENSG00000013810
ENST00000651472; ENSP00000498361; ENSG00000013810

Database of genes from NCBI RefSeq genomes

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GeneIDi
10460

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10460

UCSC genome browser

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UCSCi
uc003gdo.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093543 mRNA Translation: AAD25964.1
AJ243997 mRNA Translation: CAB53009.1
BC106071 mRNA Translation: AAI06072.1
BC111771 mRNA Translation: AAI11772.1
CCDSiCCDS3352.1
RefSeqiNP_006333.1, NM_006342.2
XP_016863142.1, XM_017007653.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LXNX-ray2.08A/B/C/D/E/F/G/H758-838[»]
5LXOX-ray2.18A/B/C/D/E/F/G/H758-838[»]
5ODSX-ray3.09E/F/G/H550-567[»]
5ODTX-ray2.02B518-563[»]
SMRiQ9Y6A5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115723, 87 interactors
CORUMiQ9Y6A5
IntActiQ9Y6A5, 73 interactors
MINTiQ9Y6A5
STRINGi9606.ENSP00000326550

PTM databases

iPTMnetiQ9Y6A5
PhosphoSitePlusiQ9Y6A5

Polymorphism and mutation databases

BioMutaiTACC3
DMDMi13431939

Proteomic databases

EPDiQ9Y6A5
jPOSTiQ9Y6A5
MassIVEiQ9Y6A5
MaxQBiQ9Y6A5
PaxDbiQ9Y6A5
PeptideAtlasiQ9Y6A5
PRIDEiQ9Y6A5
ProteomicsDBi86642

Genome annotation databases

EnsembliENST00000313288; ENSP00000326550; ENSG00000013810
ENST00000651472; ENSP00000498361; ENSG00000013810
GeneIDi10460
KEGGihsa:10460
UCSCiuc003gdo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10460
DisGeNETi10460

GeneCards: human genes, protein and diseases

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GeneCardsi
TACC3
HGNCiHGNC:11524 TACC3
HPAiCAB010111
HPA005781
HPA006050
HPA022039
MalaCardsiTACC3
MIMi605303 gene
neXtProtiNX_Q9Y6A5
OpenTargetsiENSG00000013810
Orphaneti251579 Giant cell glioblastoma
251576 Gliosarcoma
PharmGKBiPA36301

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIVK Eukaryota
ENOG410YMFS LUCA
GeneTreeiENSGT00940000158858
HOGENOMiHOG000294059
InParanoidiQ9Y6A5
KOiK14283
OMAiRITQEGQ
OrthoDBi669540at2759
PhylomeDBiQ9Y6A5
TreeFamiTF333149

Enzyme and pathway databases

ReactomeiR-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
R-HSA-9604323 Negative regulation of NOTCH4 signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TACC3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TACC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10460
PharosiQ9Y6A5

Protein Ontology

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PROi
PR:Q9Y6A5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000013810 Expressed in 147 organ(s), highest expression level in oocyte
ExpressionAtlasiQ9Y6A5 baseline and differential
GenevisibleiQ9Y6A5 HS

Family and domain databases

InterProiView protein in InterPro
IPR039915 TACC
IPR007707 TACC_C
PANTHERiPTHR13924 PTHR13924, 1 hit
PfamiView protein in Pfam
PF05010 TACC_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTACC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6A5
Secondary accession number(s): Q2NKK4, Q3KQS5, Q9UMQ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 13, 2019
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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