Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 167 (13 Feb 2019)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Tumor necrosis factor receptor superfamily member 11A

Gene

TNFRSF11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi133Sodium; via carbonyl oxygenBy similarity1
Metal bindingi134Sodium; via carbonyl oxygenBy similarity1
Metal bindingi160Sodium; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • signaling receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: BHF-UCL
  • tumor necrosis factor-activated receptor activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
LigandMetal-binding, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y6Q6

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y6Q6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 11A
Alternative name(s):
Osteoclast differentiation factor receptor
Short name:
ODFR
Receptor activator of NF-KB
CD_antigen: CD265
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFRSF11A
Synonyms:RANK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000141655.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11908 TNFRSF11A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603499 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y6Q6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 212ExtracellularSequence analysisAdd BLAST183
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 616CytoplasmicSequence analysisAdd BLAST383

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Familial expansile osteolysis (FEO)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. The osteolytic lesions develop usually in the long bones during early adulthood. FEO is often associated with early-onset deafness and loss of dentition.
See also OMIM:174810
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01151721L → LLLCALL in FEO. 1 Publication1
Paget disease of bone 2, early-onset (PDB2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone.
See also OMIM:602080
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01151621L → LALLLLCALL in PDB2. 1 Publication1
Osteopetrosis, autosomal recessive 7 (OPTB7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB7 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development. OPTB7 is associated with hypogammaglobulinemia.
See also OMIM:612301
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04678853G → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant dbSNP:rs121908659EnsemblClinVar.1
Natural variantiVAR_046789129R → C in OPTB7; a patient with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant dbSNP:rs121908657EnsemblClinVar.1
Natural variantiVAR_046791170R → G in OPTB7; two siblings with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant dbSNP:rs121908655EnsemblClinVar.1
Natural variantiVAR_046792175C → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant dbSNP:rs121908656EnsemblClinVar.1
Natural variantiVAR_046793244A → S in OPTB7; one patient with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant dbSNP:rs121908658EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease mutation, Osteopetrosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
8792

MalaCards human disease database

More...
MalaCardsi
TNFRSF11A
MIMi174810 phenotype
602080 phenotype
612301 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000141655

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
391490 Adult-onset myasthenia gravis
85195 Familial expansile osteolysis
2801 Juvenile Paget disease
280110 NON RARE IN EUROPE: Paget disease of bone
178389 Osteopetrosis-hypogammaglobulinemia syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36601

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFRSF11A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
19924309

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003458530 – 616Tumor necrosis factor receptor superfamily member 11AAdd BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 46PROSITE-ProRule annotation
Disulfide bondi47 ↔ 60PROSITE-ProRule annotation
Disulfide bondi50 ↔ 68PROSITE-ProRule annotation
Disulfide bondi71 ↔ 86PROSITE-ProRule annotation
Disulfide bondi92 ↔ 112PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 127PROSITE-ProRule annotation
Disulfide bondi124 ↔ 126PROSITE-ProRule annotation
Disulfide bondi133 ↔ 151PROSITE-ProRule annotation
Disulfide bondi154 ↔ 169PROSITE-ProRule annotation
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi175 ↔ 194PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei580PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y6Q6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y6Q6

PeptideAtlas

More...
PeptideAtlasi
Q9Y6Q6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y6Q6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86765

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y6Q6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y6Q6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141655 Expressed in 157 organ(s), highest expression level in parotid gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y6Q6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y6Q6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010391
HPA027728
HPA047976

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer (By similarity). Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TNFSF11O147889EBI-525675,EBI-15488409

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114320, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y6Q6

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9Y6Q6

Protein interaction database and analysis system

More...
IntActi
Q9Y6Q6, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9Y6Q6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000465500

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1616
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LB5X-ray2.40B342-349[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y6Q6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y6Q6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati34 – 68TNFR-Cys 1Add BLAST35
Repeati71 – 112TNFR-Cys 2Add BLAST42
Repeati114 – 151TNFR-Cys 3Add BLAST38
Repeati154 – 194TNFR-Cys 4Add BLAST41

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHUN Eukaryota
ENOG41125ED LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161211

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154659

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079274

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y6Q6

KEGG Orthology (KO)

More...
KOi
K05147

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRRNAEC

Database of Orthologous Groups

More...
OrthoDBi
1038336at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y6Q6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13411 TNFRSF11A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022323 TNFR_11
IPR022361 TNFR_11A
IPR034040 TNFRSF11A_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00020 TNFR_c6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01961 TNFACTORR11
PR01974 TNFACTORR11A

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00208 TNFR, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y6Q6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPRARRRRP LFALLLLCAL LARLQVALQI APPCTSEKHY EHLGRCCNKC
60 70 80 90 100
EPGKYMSSKC TTTSDSVCLP CGPDEYLDSW NEEDKCLLHK VCDTGKALVA
110 120 130 140 150
VVAGNSTTPR RCACTAGYHW SQDCECCRRN TECAPGLGAQ HPLQLNKDTV
160 170 180 190 200
CKPCLAGYFS DAFSSTDKCR PWTNCTFLGK RVEHHGTEKS DAVCSSSLPA
210 220 230 240 250
RKPPNEPHVY LPGLIILLLF ASVALVAAII FGVCYRKKGK ALTANLWHWI
260 270 280 290 300
NEACGRLSGD KESSGDSCVS THTANFGQQG ACEGVLLLTL EEKTFPEDMC
310 320 330 340 350
YPDQGGVCQG TCVGGGPYAQ GEDARMLSLV SKTEIEEDSF RQMPTEDEYM
360 370 380 390 400
DRPSQPTDQL LFLTEPGSKS TPPFSEPLEV GENDSLSQCF TGTQSTVGSE
410 420 430 440 450
SCNCTEPLCR TDWTPMSSEN YLQKEVDSGH CPHWAASPSP NWADVCTGCR
460 470 480 490 500
NPPGEDCEPL VGSPKRGPLP QCAYGMGLPP EEEASRTEAR DQPEDGADGR
510 520 530 540 550
LPSSARAGAG SGSSPGGQSP ASGNVTGNSN STFISSGQVM NFKGDIIVVY
560 570 580 590 600
VSQTSQEGAA AAAEPMGRPV QEETLARRDS FAGNGPRFPD PCGGPEGLRE
610
PEKASRPVQE QGGAKA
Length:616
Mass (Da):66,034
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3DE9A7A08196F81
GO
Isoform 2 (identifier: Q9Y6Q6-2) [UniParc]FASTAAdd to basket
Also known as: delta7,8,9

The sequence of this isoform differs from the canonical sequence as follows:
     206-522: Missing.

Show »
Length:299
Mass (Da):32,318
Checksum:i0EF38515CF29F18D
GO
Isoform 3 (identifier: Q9Y6Q6-3) [UniParc]FASTAAdd to basket
Also known as: delta8,9

The sequence of this isoform differs from the canonical sequence as follows:
     244-522: Missing.

Show »
Length:337
Mass (Da):36,399
Checksum:i9200CEF495CCF5B3
GO
Isoform 4 (identifier: Q9Y6Q6-4) [UniParc]FASTAAdd to basket
Also known as: delta9

The sequence of this isoform differs from the canonical sequence as follows:
     263-263: S → M
     264-616: Missing.

Show »
Length:263
Mass (Da):28,965
Checksum:iA6E72E8DEFA676C2
GO
Isoform 5 (identifier: Q9Y6Q6-5) [UniParc]FASTAAdd to basket
Also known as: exon9a

The sequence of this isoform differs from the canonical sequence as follows:
     523-616: GNVTGNSNST...PVQEQGGAKA → D

Show »
Length:523
Mass (Da):56,402
Checksum:i653957CFE411BEB5
GO
Isoform RANK-e5a (identifier: Q9Y6Q6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-157: LQLNKDTVCKPCLAG → C

Note: Reduced ability to bind RANKL and to activate NF-kappaB as compared to isoform 1.
Show »
Length:602
Mass (Da):64,552
Checksum:i820338A19FAE9D03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PR41A0A1W2PR41_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF11A
263Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92999 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01151621L → LALLLLCALL in PDB2. 1 Publication1
Natural variantiVAR_01151721L → LLLCALL in FEO. 1 Publication1
Natural variantiVAR_04678853G → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant dbSNP:rs121908659EnsemblClinVar.1
Natural variantiVAR_046789129R → C in OPTB7; a patient with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant dbSNP:rs121908657EnsemblClinVar.1
Natural variantiVAR_046790141H → Y. Corresponds to variant dbSNP:rs35211496EnsemblClinVar.1
Natural variantiVAR_046791170R → G in OPTB7; two siblings with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant dbSNP:rs121908655EnsemblClinVar.1
Natural variantiVAR_046792175C → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant dbSNP:rs121908656EnsemblClinVar.1
Natural variantiVAR_011518192A → V1 PublicationCorresponds to variant dbSNP:rs1805034EnsemblClinVar.1
Natural variantiVAR_046793244A → S in OPTB7; one patient with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant dbSNP:rs121908658EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054179143 – 157LQLNK…PCLAG → C in isoform RANK-e5a. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_046901206 – 522Missing in isoform 2. 2 PublicationsAdd BLAST317
Alternative sequenceiVSP_054180244 – 522Missing in isoform 3. 1 PublicationAdd BLAST279
Alternative sequenceiVSP_054181263S → M in isoform 4. 1 Publication1
Alternative sequenceiVSP_054182264 – 616Missing in isoform 4. 1 PublicationAdd BLAST353
Alternative sequenceiVSP_054183523 – 616GNVTG…GGAKA → D in isoform 5. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF018253 mRNA Translation: AAB86809.1
HF584702 mRNA Translation: CCQ44072.1
HE647782 mRNA Translation: CCF23032.1
HE649916 mRNA Translation: CCF55033.1
HE649917 mRNA Translation: CCF55034.1
HE659518 mRNA Translation: CCF77738.1
AB209762 mRNA Translation: BAD92999.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11980.1 [Q9Y6Q6-1]
CCDS59324.1 [Q9Y6Q6-2]
CCDS74227.1 [Q9Y6Q6-4]
CCDS74228.1 [Q9Y6Q6-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001257878.1, NM_001270949.1 [Q9Y6Q6-4]
NP_001257879.1, NM_001270950.1 [Q9Y6Q6-3]
NP_001257880.1, NM_001270951.1 [Q9Y6Q6-2]
NP_001265197.1, NM_001278268.1 [Q9Y6Q6-6]
NP_003830.1, NM_003839.3 [Q9Y6Q6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.204044
Hs.621477

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000269485; ENSP00000269485; ENSG00000141655 [Q9Y6Q6-2]
ENST00000586569; ENSP00000465500; ENSG00000141655 [Q9Y6Q6-1]
ENST00000616710; ENSP00000479567; ENSG00000141655 [Q9Y6Q6-4]
ENST00000617039; ENSP00000482466; ENSG00000141655 [Q9Y6Q6-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8792

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8792

UCSC genome browser

More...
UCSCi
uc002lin.5 human [Q9Y6Q6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018253 mRNA Translation: AAB86809.1
HF584702 mRNA Translation: CCQ44072.1
HE647782 mRNA Translation: CCF23032.1
HE649916 mRNA Translation: CCF55033.1
HE649917 mRNA Translation: CCF55034.1
HE659518 mRNA Translation: CCF77738.1
AB209762 mRNA Translation: BAD92999.1 Different initiation.
CCDSiCCDS11980.1 [Q9Y6Q6-1]
CCDS59324.1 [Q9Y6Q6-2]
CCDS74227.1 [Q9Y6Q6-4]
CCDS74228.1 [Q9Y6Q6-3]
RefSeqiNP_001257878.1, NM_001270949.1 [Q9Y6Q6-4]
NP_001257879.1, NM_001270950.1 [Q9Y6Q6-3]
NP_001257880.1, NM_001270951.1 [Q9Y6Q6-2]
NP_001265197.1, NM_001278268.1 [Q9Y6Q6-6]
NP_003830.1, NM_003839.3 [Q9Y6Q6-1]
UniGeneiHs.204044
Hs.621477

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LB5X-ray2.40B342-349[»]
ProteinModelPortaliQ9Y6Q6
SMRiQ9Y6Q6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114320, 12 interactors
CORUMiQ9Y6Q6
ELMiQ9Y6Q6
IntActiQ9Y6Q6, 6 interactors
MINTiQ9Y6Q6
STRINGi9606.ENSP00000465500

PTM databases

iPTMnetiQ9Y6Q6
PhosphoSitePlusiQ9Y6Q6

Polymorphism and mutation databases

BioMutaiTNFRSF11A
DMDMi19924309

Proteomic databases

jPOSTiQ9Y6Q6
PaxDbiQ9Y6Q6
PeptideAtlasiQ9Y6Q6
PRIDEiQ9Y6Q6
ProteomicsDBi86765

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8792
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269485; ENSP00000269485; ENSG00000141655 [Q9Y6Q6-2]
ENST00000586569; ENSP00000465500; ENSG00000141655 [Q9Y6Q6-1]
ENST00000616710; ENSP00000479567; ENSG00000141655 [Q9Y6Q6-4]
ENST00000617039; ENSP00000482466; ENSG00000141655 [Q9Y6Q6-3]
GeneIDi8792
KEGGihsa:8792
UCSCiuc002lin.5 human [Q9Y6Q6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8792
DisGeNETi8792
EuPathDBiHostDB:ENSG00000141655.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNFRSF11A
HGNCiHGNC:11908 TNFRSF11A
HPAiCAB010391
HPA027728
HPA047976
MalaCardsiTNFRSF11A
MIMi174810 phenotype
602080 phenotype
603499 gene
612301 phenotype
neXtProtiNX_Q9Y6Q6
OpenTargetsiENSG00000141655
Orphaneti391490 Adult-onset myasthenia gravis
85195 Familial expansile osteolysis
2801 Juvenile Paget disease
280110 NON RARE IN EUROPE: Paget disease of bone
178389 Osteopetrosis-hypogammaglobulinemia syndrome
PharmGKBiPA36601

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHUN Eukaryota
ENOG41125ED LUCA
GeneTreeiENSGT00940000161211
HOGENOMiHOG000154659
HOVERGENiHBG079274
InParanoidiQ9Y6Q6
KOiK05147
OMAiCRRNAEC
OrthoDBi1038336at2759
PhylomeDBiQ9Y6Q6

Enzyme and pathway databases

ReactomeiR-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
SignaLinkiQ9Y6Q6
SIGNORiQ9Y6Q6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNFRSF11A human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RANK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8792

Protein Ontology

More...
PROi
PR:Q9Y6Q6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141655 Expressed in 157 organ(s), highest expression level in parotid gland
ExpressionAtlasiQ9Y6Q6 baseline and differential
GenevisibleiQ9Y6Q6 HS

Family and domain databases

CDDicd13411 TNFRSF11A, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022323 TNFR_11
IPR022361 TNFR_11A
IPR034040 TNFRSF11A_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01961 TNFACTORR11
PR01974 TNFACTORR11A
SMARTiView protein in SMART
SM00208 TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y6Q6
Secondary accession number(s): I4EC36
, I4EC38, I4EC39, I7JE63, N0GVH0, Q59EP9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: February 13, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again