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UniProtKB - V9GZ83 (V9GZ83_RAT)

Entry version 43 (31 Jul 2019)
Sequence version 1 (19 Feb 2014)
Previous versions | rss
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Protein
Submitted name:

Ryanodine receptor 1

Gene

Ryr1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ryanodine receptor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ryr1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...RGDi		1586637 Ryr1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		V9GZ83

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000020557 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		V9GZ83 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini99 – 154MIRInterPro annotationAdd BLAST56
Domaini161 – 206MIRInterPro annotationAdd BLAST46
Domaini212 – 266MIRInterPro annotationAdd BLAST55
Domaini272 – 329MIRInterPro annotationAdd BLAST58
Domaini337 – 394MIRInterPro annotationAdd BLAST58
Domaini583 – 799B30.2/SPRYInterPro annotationAdd BLAST217
Domaini1015 – 1210B30.2/SPRYInterPro annotationAdd BLAST196
Domaini1359 – 1572B30.2/SPRYInterPro annotationAdd BLAST214

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1309 – 1387DisorderedSequence analysisAdd BLAST79
Regioni1667 – 1686DisorderedSequence analysisAdd BLAST20
Regioni1871 – 1924DisorderedSequence analysisAdd BLAST54
Regioni2390 – 2412DisorderedSequence analysisAdd BLAST23
Regioni2826 – 2857DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2912 – 2932Sequence analysisAdd BLAST21
Coiled coili3370 – 3390Sequence analysisAdd BLAST21
Coiled coili3676 – 3696Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1372 – 1387PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1872 – 1922AcidicSequence analysisAdd BLAST51
Compositional biasi2826 – 2842PolyampholyteSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2243 Eukaryota
ENOG410YCNW LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155288

Family and domain databases

Conserved Domains Database

More...CDDi		cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR014821 Ins145_P3_rcpt
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR035910 RyR/IP3R_RIH_dom_sf
IPR033215 RyR1
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom

The PANTHER Classification System

More...PANTHERi		PTHR13715:SF15 PTHR13715:SF15, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF02815 MIR, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00795 RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100909 SSF100909, 2 hits
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

V9GZ83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDGGGEGED EVQFLRTDDE VVLQCSATVL KEQLKLCLAA EGFGNRLCFL 
        60         70         80         90        100
EPTSNAQNVP PDLAICCFIL EQSLSVRALQ EMLANTVEAG VESSQGGGHR 
       110        120        130        140        150
TLLYGHAILL RHAHSRMYLS CLTTSRSMTD KLAFDVGLQE DATGEACWWT 
       160        170        180        190        200
MHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSTASGEL QVDASFMQTL 
       210        220        230        240        250
WNMNPICSCC EEGFVTGGHV LRLFHGHMDE CLTISPSDSD DQRRLVYYEG 
       260        270        280        290        300
GPVCTHARSL WRLEPLRISW SGSHLRWGQP LRIRHVTTGR YLALTEDQGL 
       310        320        330        340        350
VVVDASKAHT KATSFCFRIS KEKLDVAPKR DVEGMGPPEI KYGESLCFVQ 
       360        370        380        390        400
HVASGLWLTY AAPDPKALRL GVLKKKAMLH QEGHMDDALS LTRCQQEESQ 
       410        420        430        440        450
AARMIYSTAG LYNQFIKGLD SFSGKPRGSG PPAGSALPIE GVILSLQDLI 
       460        470        480        490        500
GYFEPPSEEL QHEEKQTKLR SLRNRQSLFQ EEGMLSLVLN CIDRLNVYTT 
       510        520        530        540        550
AAHFAEFAGE EAAESWKEIV NLLYELLASL IRGNRTNCAL FSTNLDWLVS 
       560        570        580        590        600
KLDRLEASSG ILEVLYCVLI ESPEVLNIIQ ENHIKSIISL LDKHGRNHKV 
       610        620        630        640        650
LDVLCSLCVC NGVAVRSNQD LITENLLPGR ELLLQTNLIN YVTSIRPNIF 
       660        670        680        690        700
VGRAEGSTQY GKWYFEVMVD EVAPFLTAQA THLRVGWALS EGYSPYPGGG 
       710        720        730        740        750
EGWGGNGVGD DLYSYGFDGL HLWTGHVARP VTSPGQHLLG PEDVVSCCLD 
       760        770        780        790        800
LSVPSISFRI NGCPVQGVFE SFNLDGLFFP VVSFSAGIKV RFLLGGRHGE 
       810        820        830        840        850
FKFLPPPGYA PCHEAVLPRE RLHLQPIKEY RREGPRGPHL VGPSRCLSHL 
       860        870        880        890        900
DFVPCPVDTI QIVLPPHLER IREKLAENIH ELWALTRIEQ GWTYGPVRDD 
       910        920        930        940        950
NKRLHPCLVD FHSLPEPERN YNLQMSGETL KTLLALGCHV GMADEKAEDN 
       960        970        980        990       1000
LKKTKLPKTY MMNNGYKPAP LDLSHVRLTP AQTTLVDRLA ENGHNVWARD 
      1010       1020       1030       1040       1050
RVAQGWSYSA VQDIPARRNP RLVPYRLLDE ATKRSNRDSL CQAVRTLLGY 
      1060       1070       1080       1090       1100
GYNIEPPDQE PSQVDSQSRG DRARIFRAEK SYAVQSGRWY FEFEAVTTGE 
      1110       1120       1130       1140       1150
MRVGWARPEL RPDVELGADD LAYVFNGHRG QRWHLGSEPF GRPWQSGDVV 
      1160       1170       1180       1190       1200
GCMIDLTENT IIFTLNGEVL MSDSGSETAF REIEIGDGFL PVCSLGPGQV 
      1210       1220       1230       1240       1250
GHLNLGQDVS SLRFFAICGL QEGFEPFAIN MQRPVTTWFS KSLPQFEPVP 
      1260       1270       1280       1290       1300
LEHPHYEVAR MDGTVDTPPC LRLTHRTWGS QNSLVEMLFL RLSLPVQFHQ 
      1310       1320       1330       1340       1350
HFRCTAGATP LASPGLQPPA EDEARAAEPD TDYENLRRSA GGWGEAEAGK 
      1360       1370       1380       1390       1400
DGTAKEGTPG GAAQPGVEAQ PARAENEKDA TTEKNKKRGF LFKAKKVAMM 
      1410       1420       1430       1440       1450
TQPPSTPALP RLPRDVVPAD NRDDPEIILN TTTYYYSVRV FAGQEPSCVW 
      1460       1470       1480       1490       1500
VGWVTPDYHQ HDMSFDLSKV RAVTVTMGDE QGNVHSSLKC SNCYMVWGGD 
      1510       1520       1530       1540       1550
FVSPGQQGRI SHTDLVIGCL VDLATGLMTF TANGKESNTF FQVEPNTKLF 
      1560       1570       1580       1590       1600
PAVFVLPTHQ NVVQFDLRPG ANIMPLSAAM FLSERKNPAP QCPPRLEVQM 
      1610       1620       1630       1640       1650
LMPVSWSRMP NHFLHVDTRR AGERLGWAVQ CQEPLMMMAL HIPEENSEPY 
      1660       1670       1680       1690       1700
IHLKRAQLDP RDLRDYRDTK FDSESSDSDQ TPQPGCYHVD QAQLLHALED 
      1710       1720       1730       1740       1750
AHLPGPLRAG YYDLLISIHL ESACRSRRSM LSEYIVPLTE ETRAITLFPP 
      1760       1770       1780       1790       1800
GRSAEDGPRR HGLPGVGVTT SLRPPHHFSP PCFVVALPAA GAAEAPARLS 
      1810       1820       1830       1840       1850
PAIPLEALRD KALRMLGEAV RDGGQHARDP VGGSVEFQFV PVLKLVSTLL 
      1860       1870       1880       1890       1900
VMGVFSDEDV KQILKMIEPE VFTEEEEVEE EEEEEEEDEE EKEEDEEEEA 
      1910       1920       1930       1940       1950
HEKEDEEKEE AEEAAEEEKE ELEEGLLQMK LPESVKLQMC HLLEYFCDQE 
      1960       1970       1980       1990       2000
LQHRVESLAA FAERYVDKLQ SNQRGRYGLL MKAFTMSAAE TARRTREFRS 
      2010       2020       2030       2040       2050
PPQEQINMLL QFKNGADEED CPLPEEIRED LVNFHQDLLA HCGIQLEGEE 
      2060       2070       2080       2090       2100
EEPEEESTLG SRLMSLLEKV RLVKKKEEKP EEEPAAEEHK PQSLQELVSH 
      2110       2120       2130       2140       2150
TVVRWAQEDF VQSPELVRAM FSLLHRQYDG LGELLRALPR AYTISLSSVE 
      2160       2170       2180       2190       2200
DTMSLLECLG QIRSLLIVQM GPQEENLMIQ SIGNIMNNKV FYQHPNLMRA 
      2210       2220       2230       2240       2250
LGMHETVMEV MVNVLGGGES KEIRFPKMVT SCCRFLCYFC RISRQNQRSM 
      2260       2270       2280       2290       2300
FDHLSYLLEN SGIGLGMQGS TPLDVAAASV IDNNELALAL QEQDLEKVVS 
      2310       2320       2330       2340       2350
YLAGCGLQSC PMLLAKGYPD IGWNPCGGER YLDFLRFAVF VNGESVEENA 
      2360       2370       2380       2390       2400
NVVVRLLIRK PECFGPALRG EGGSGLLAAI EEAIRISEDP ARDGPGVRRD 
      2410       2420       2430       2440       2450
RRREHFGEEP PEENRVHLGH AIMSFYAALI DLLGRCAPEM HLIQAGKGEA 
      2460       2470       2480       2490       2500
LRIRAILRSL VPLDDLVGII SLPLQIPTLG KDGALVQPKM SASFVPDHKA 
      2510       2520       2530       2540       2550
SMVLFLDRVY GIENQDFLLH VLDVGFLPDM RAAASLDTAT FSRRWALALN 
      2560       2570       2580       2590       2600
RYLCLAVLPL ITKCAPLLRG TEHRAIMVDS MLHTVYRLSR GRSLTKAQRD 
      2610       2620       2630       2640       2650
VIEDCLMALC RYIRPSMLQH LLRRLVFDVP ILNEFAKMPL KLLTNHYERC 
      2660       2670       2680       2690       2700
WKYYCLPTGW ANFGVTSEEE LHLTRKLFWG IFDSLAHKKY DQELYRIAMP 
      2710       2720       2730       2740       2750
CLCAIAGALP PDYVDASYSS KTEKKATVDA EGNFDPRPVE TLNVIIPEKL 
      2760       2770       2780       2790       2800
DSFINKFAEY AHEKWAFDKI QNNWSYGENI DEELKTHPML RPYKTFSEKD 
      2810       2820       2830       2840       2850
KEIYRWPIKE SLKAMIAWEW TVEKAREGEE EKTEKKKTRK ISQTAQTYDP 
      2860       2870       2880       2890       2900
REGYNPQPPD LSVVTLSREL QAMAEQLAEN YHNTWGRKKK QELEAKGGGS 
      2910       2920       2930       2940       2950
HPLLVPYDTL TAKEKARDRE KAQELLKFLQ MNGYAVTRHG KDMELDTSSI 
      2960       2970       2980       2990       3000
EKRFAFGFLQ QLLRWMDISQ EFIAHLEAVV SSGRVEKSPH EQEIKFFAKI 
      3010       3020       3030       3040       3050
LLPLINQYFT NHCLYFLSTP AKVLGSGGHA SNKEKEMITS LFCKLAALVR 
      3060       3070       3080       3090       3100
HRVSLFGTDA PAVVNCLHIL ARSLDARTVM KSGPEIVKAG LRSFFESASE 
      3110       3120       3130       3140       3150
DIEKMVENLR LGKVSQARTQ VKGVGQNLTY TTVALLPVLT TLFQHIAQHQ 
      3160       3170       3180       3190       3200
FGDDVILDDV QVSCYRTLCS IYSLGTTRNP YVEKLRPALG ECLARLAAAM 
      3210       3220       3230       3240       3250
PVAFLEPELN EYNACSVYTT KSPRERAILG LPNSVEEMCP DIPVLERLMA 
      3260       3270       3280       3290       3300
EIGGLAESGA RYTEMPHVIE ITLPMLCSYL PRWWERGPEA PPPALPAGAP 
      3310       3320       3330       3340       3350
PPCTAVTSDH LNSLLGNILR IIVNNLGIDE ASWMKRLAVF AQPIVSRARP 
      3360       3370       3380       3390       3400
ELLRSHFIPT IGRLRKRAGK VVAEEEQLRL EAKAEAEEGE LLVRDEFSVL 
      3410       3420       3430       3440       3450
CRDLYALYPL LIRYVDNNRS AWPRLPPSPS SSFSLPSPSE LGRWLTSCTG 
      3460       3470       3480       3490       3500
GHQLYEESFT VPLILDNAAF PLARNQSRAI GCAGVVRSGG SDQERTKKKR 
      3510       3520       3530       3540       3550
RGDRYSVQTS LIVATLKKML PIGLNMCAPT DQDLIVLAKA RYALKDTDEE 
      3560       3570       3580       3590       3600
VREFLQNNLN LQGKVEGSPS LRWQMALYRG VPGREEDADD PEKIVRRVQE 
      3610       3620       3630       3640       3650
VSAVLYHLDQ TEHPYKSKKA VWHKLLSKQR RRAVVACFRM TPLYNLPTHR 
      3660       3670       3680       3690       3700
ACNMFLESYK ASWILTEDHS FEDRMIDDLS KAGEQEEEEE EVEEKKPDPL 
      3710       3720       3730       3740       3750
HQLVLHFSRT ALTEKSKLDE DYLYMAYADI MAKSCHLEEG GENVEEGGEE 
      3760       3770       3780       3790       3800
EEVEVSFEEK EMEKQRLLYQ QSRLHNRGAA EMVLQMISAC KGETGAMVSS 
      3810       3820       3830       3840       3850
TLKLGISILN GGNAEVQQKM LDYLKDKKEV GFFQSIQALM QTCRWPHKTL 
      3860       3870       3880       3890       3900
SQREGQEERV MKVQTSGTLV IINRQNGEKV MADDEFTQDL FRFLQLLCEG 

HNN
Length:3,903
Mass (Da):438,608
Last modified:February 19, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00A45C0BBA9C9B29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMY4RYR1_RAT
Ryanodine receptor 1
Ryr1
5,035Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K5J1A0A0G2K5J1_RAT
Ryanodine receptor 1
Ryr1
5,012Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR07002875 Genomic DNA No translation available.
AABR07002876 Genomic DNA No translation available.
AABR07071894 Genomic DNA No translation available.
AC118147 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000027893; ENSRNOP00000027893; ENSRNOG00000020557

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07002875 Genomic DNA No translation available.
AABR07002876 Genomic DNA No translation available.
AABR07071894 Genomic DNA No translation available.
AC118147 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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SWISS-MODEL Interactive Workspace

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Proteomic databases

PRIDEiV9GZ83

Genome annotation databases

EnsembliENSRNOT00000027893; ENSRNOP00000027893; ENSRNOG00000020557

Organism-specific databases

RGDi1586637 Ryr1

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
GeneTreeiENSGT00940000155288

Gene expression databases

BgeeiENSRNOG00000020557 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiV9GZ83 baseline and differential

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR014821 Ins145_P3_rcpt
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR035910 RyR/IP3R_RIH_dom_sf
IPR033215 RyR1
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PANTHERiPTHR13715:SF15 PTHR13715:SF15, 1 hit
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF02815 MIR, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiV9GZ83_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: V9GZ83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 19, 2014
Last sequence update: February 19, 2014
Last modified: July 31, 2019
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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