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Entry version 43 (31 Jul 2019)
Sequence version 1 (19 Feb 2014)
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Protein
Submitted name:

Ryanodine receptor 1

Gene

Ryr1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ryanodine receptor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ryr1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
1586637 Ryr1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
V9GZ83

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000020557 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
V9GZ83 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini99 – 154MIRInterPro annotationAdd BLAST56
Domaini161 – 206MIRInterPro annotationAdd BLAST46
Domaini212 – 266MIRInterPro annotationAdd BLAST55
Domaini272 – 329MIRInterPro annotationAdd BLAST58
Domaini337 – 394MIRInterPro annotationAdd BLAST58
Domaini583 – 799B30.2/SPRYInterPro annotationAdd BLAST217
Domaini1015 – 1210B30.2/SPRYInterPro annotationAdd BLAST196
Domaini1359 – 1572B30.2/SPRYInterPro annotationAdd BLAST214

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1309 – 1387DisorderedSequence analysisAdd BLAST79
Regioni1667 – 1686DisorderedSequence analysisAdd BLAST20
Regioni1871 – 1924DisorderedSequence analysisAdd BLAST54
Regioni2390 – 2412DisorderedSequence analysisAdd BLAST23
Regioni2826 – 2857DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2912 – 2932Sequence analysisAdd BLAST21
Coiled coili3370 – 3390Sequence analysisAdd BLAST21
Coiled coili3676 – 3696Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1372 – 1387PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1872 – 1922AcidicSequence analysisAdd BLAST51
Compositional biasi2826 – 2842PolyampholyteSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243 Eukaryota
ENOG410YCNW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155288

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR014821 Ins145_P3_rcpt
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR035910 RyR/IP3R_RIH_dom_sf
IPR033215 RyR1
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13715:SF15 PTHR13715:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF02815 MIR, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795 RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 2 hits
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

V9GZ83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDGGGEGED EVQFLRTDDE VVLQCSATVL KEQLKLCLAA EGFGNRLCFL
60 70 80 90 100
EPTSNAQNVP PDLAICCFIL EQSLSVRALQ EMLANTVEAG VESSQGGGHR
110 120 130 140 150
TLLYGHAILL RHAHSRMYLS CLTTSRSMTD KLAFDVGLQE DATGEACWWT
160 170 180 190 200
MHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSTASGEL QVDASFMQTL
210 220 230 240 250
WNMNPICSCC EEGFVTGGHV LRLFHGHMDE CLTISPSDSD DQRRLVYYEG
260 270 280 290 300
GPVCTHARSL WRLEPLRISW SGSHLRWGQP LRIRHVTTGR YLALTEDQGL
310 320 330 340 350
VVVDASKAHT KATSFCFRIS KEKLDVAPKR DVEGMGPPEI KYGESLCFVQ
360 370 380 390 400
HVASGLWLTY AAPDPKALRL GVLKKKAMLH QEGHMDDALS LTRCQQEESQ
410 420 430 440 450
AARMIYSTAG LYNQFIKGLD SFSGKPRGSG PPAGSALPIE GVILSLQDLI
460 470 480 490 500
GYFEPPSEEL QHEEKQTKLR SLRNRQSLFQ EEGMLSLVLN CIDRLNVYTT
510 520 530 540 550
AAHFAEFAGE EAAESWKEIV NLLYELLASL IRGNRTNCAL FSTNLDWLVS
560 570 580 590 600
KLDRLEASSG ILEVLYCVLI ESPEVLNIIQ ENHIKSIISL LDKHGRNHKV
610 620 630 640 650
LDVLCSLCVC NGVAVRSNQD LITENLLPGR ELLLQTNLIN YVTSIRPNIF
660 670 680 690 700
VGRAEGSTQY GKWYFEVMVD EVAPFLTAQA THLRVGWALS EGYSPYPGGG
710 720 730 740 750
EGWGGNGVGD DLYSYGFDGL HLWTGHVARP VTSPGQHLLG PEDVVSCCLD
760 770 780 790 800
LSVPSISFRI NGCPVQGVFE SFNLDGLFFP VVSFSAGIKV RFLLGGRHGE
810 820 830 840 850
FKFLPPPGYA PCHEAVLPRE RLHLQPIKEY RREGPRGPHL VGPSRCLSHL
860 870 880 890 900
DFVPCPVDTI QIVLPPHLER IREKLAENIH ELWALTRIEQ GWTYGPVRDD
910 920 930 940 950
NKRLHPCLVD FHSLPEPERN YNLQMSGETL KTLLALGCHV GMADEKAEDN
960 970 980 990 1000
LKKTKLPKTY MMNNGYKPAP LDLSHVRLTP AQTTLVDRLA ENGHNVWARD
1010 1020 1030 1040 1050
RVAQGWSYSA VQDIPARRNP RLVPYRLLDE ATKRSNRDSL CQAVRTLLGY
1060 1070 1080 1090 1100
GYNIEPPDQE PSQVDSQSRG DRARIFRAEK SYAVQSGRWY FEFEAVTTGE
1110 1120 1130 1140 1150
MRVGWARPEL RPDVELGADD LAYVFNGHRG QRWHLGSEPF GRPWQSGDVV
1160 1170 1180 1190 1200
GCMIDLTENT IIFTLNGEVL MSDSGSETAF REIEIGDGFL PVCSLGPGQV
1210 1220 1230 1240 1250
GHLNLGQDVS SLRFFAICGL QEGFEPFAIN MQRPVTTWFS KSLPQFEPVP
1260 1270 1280 1290 1300
LEHPHYEVAR MDGTVDTPPC LRLTHRTWGS QNSLVEMLFL RLSLPVQFHQ
1310 1320 1330 1340 1350
HFRCTAGATP LASPGLQPPA EDEARAAEPD TDYENLRRSA GGWGEAEAGK
1360 1370 1380 1390 1400
DGTAKEGTPG GAAQPGVEAQ PARAENEKDA TTEKNKKRGF LFKAKKVAMM
1410 1420 1430 1440 1450
TQPPSTPALP RLPRDVVPAD NRDDPEIILN TTTYYYSVRV FAGQEPSCVW
1460 1470 1480 1490 1500
VGWVTPDYHQ HDMSFDLSKV RAVTVTMGDE QGNVHSSLKC SNCYMVWGGD
1510 1520 1530 1540 1550
FVSPGQQGRI SHTDLVIGCL VDLATGLMTF TANGKESNTF FQVEPNTKLF
1560 1570 1580 1590 1600
PAVFVLPTHQ NVVQFDLRPG ANIMPLSAAM FLSERKNPAP QCPPRLEVQM
1610 1620 1630 1640 1650
LMPVSWSRMP NHFLHVDTRR AGERLGWAVQ CQEPLMMMAL HIPEENSEPY
1660 1670 1680 1690 1700
IHLKRAQLDP RDLRDYRDTK FDSESSDSDQ TPQPGCYHVD QAQLLHALED
1710 1720 1730 1740 1750
AHLPGPLRAG YYDLLISIHL ESACRSRRSM LSEYIVPLTE ETRAITLFPP
1760 1770 1780 1790 1800
GRSAEDGPRR HGLPGVGVTT SLRPPHHFSP PCFVVALPAA GAAEAPARLS
1810 1820 1830 1840 1850
PAIPLEALRD KALRMLGEAV RDGGQHARDP VGGSVEFQFV PVLKLVSTLL
1860 1870 1880 1890 1900
VMGVFSDEDV KQILKMIEPE VFTEEEEVEE EEEEEEEDEE EKEEDEEEEA
1910 1920 1930 1940 1950
HEKEDEEKEE AEEAAEEEKE ELEEGLLQMK LPESVKLQMC HLLEYFCDQE
1960 1970 1980 1990 2000
LQHRVESLAA FAERYVDKLQ SNQRGRYGLL MKAFTMSAAE TARRTREFRS
2010 2020 2030 2040 2050
PPQEQINMLL QFKNGADEED CPLPEEIRED LVNFHQDLLA HCGIQLEGEE
2060 2070 2080 2090 2100
EEPEEESTLG SRLMSLLEKV RLVKKKEEKP EEEPAAEEHK PQSLQELVSH
2110 2120 2130 2140 2150
TVVRWAQEDF VQSPELVRAM FSLLHRQYDG LGELLRALPR AYTISLSSVE
2160 2170 2180 2190 2200
DTMSLLECLG QIRSLLIVQM GPQEENLMIQ SIGNIMNNKV FYQHPNLMRA
2210 2220 2230 2240 2250
LGMHETVMEV MVNVLGGGES KEIRFPKMVT SCCRFLCYFC RISRQNQRSM
2260 2270 2280 2290 2300
FDHLSYLLEN SGIGLGMQGS TPLDVAAASV IDNNELALAL QEQDLEKVVS
2310 2320 2330 2340 2350
YLAGCGLQSC PMLLAKGYPD IGWNPCGGER YLDFLRFAVF VNGESVEENA
2360 2370 2380 2390 2400
NVVVRLLIRK PECFGPALRG EGGSGLLAAI EEAIRISEDP ARDGPGVRRD
2410 2420 2430 2440 2450
RRREHFGEEP PEENRVHLGH AIMSFYAALI DLLGRCAPEM HLIQAGKGEA
2460 2470 2480 2490 2500
LRIRAILRSL VPLDDLVGII SLPLQIPTLG KDGALVQPKM SASFVPDHKA
2510 2520 2530 2540 2550
SMVLFLDRVY GIENQDFLLH VLDVGFLPDM RAAASLDTAT FSRRWALALN
2560 2570 2580 2590 2600
RYLCLAVLPL ITKCAPLLRG TEHRAIMVDS MLHTVYRLSR GRSLTKAQRD
2610 2620 2630 2640 2650
VIEDCLMALC RYIRPSMLQH LLRRLVFDVP ILNEFAKMPL KLLTNHYERC
2660 2670 2680 2690 2700
WKYYCLPTGW ANFGVTSEEE LHLTRKLFWG IFDSLAHKKY DQELYRIAMP
2710 2720 2730 2740 2750
CLCAIAGALP PDYVDASYSS KTEKKATVDA EGNFDPRPVE TLNVIIPEKL
2760 2770 2780 2790 2800
DSFINKFAEY AHEKWAFDKI QNNWSYGENI DEELKTHPML RPYKTFSEKD
2810 2820 2830 2840 2850
KEIYRWPIKE SLKAMIAWEW TVEKAREGEE EKTEKKKTRK ISQTAQTYDP
2860 2870 2880 2890 2900
REGYNPQPPD LSVVTLSREL QAMAEQLAEN YHNTWGRKKK QELEAKGGGS
2910 2920 2930 2940 2950
HPLLVPYDTL TAKEKARDRE KAQELLKFLQ MNGYAVTRHG KDMELDTSSI
2960 2970 2980 2990 3000
EKRFAFGFLQ QLLRWMDISQ EFIAHLEAVV SSGRVEKSPH EQEIKFFAKI
3010 3020 3030 3040 3050
LLPLINQYFT NHCLYFLSTP AKVLGSGGHA SNKEKEMITS LFCKLAALVR
3060 3070 3080 3090 3100
HRVSLFGTDA PAVVNCLHIL ARSLDARTVM KSGPEIVKAG LRSFFESASE
3110 3120 3130 3140 3150
DIEKMVENLR LGKVSQARTQ VKGVGQNLTY TTVALLPVLT TLFQHIAQHQ
3160 3170 3180 3190 3200
FGDDVILDDV QVSCYRTLCS IYSLGTTRNP YVEKLRPALG ECLARLAAAM
3210 3220 3230 3240 3250
PVAFLEPELN EYNACSVYTT KSPRERAILG LPNSVEEMCP DIPVLERLMA
3260 3270 3280 3290 3300
EIGGLAESGA RYTEMPHVIE ITLPMLCSYL PRWWERGPEA PPPALPAGAP
3310 3320 3330 3340 3350
PPCTAVTSDH LNSLLGNILR IIVNNLGIDE ASWMKRLAVF AQPIVSRARP
3360 3370 3380 3390 3400
ELLRSHFIPT IGRLRKRAGK VVAEEEQLRL EAKAEAEEGE LLVRDEFSVL
3410 3420 3430 3440 3450
CRDLYALYPL LIRYVDNNRS AWPRLPPSPS SSFSLPSPSE LGRWLTSCTG
3460 3470 3480 3490 3500
GHQLYEESFT VPLILDNAAF PLARNQSRAI GCAGVVRSGG SDQERTKKKR
3510 3520 3530 3540 3550
RGDRYSVQTS LIVATLKKML PIGLNMCAPT DQDLIVLAKA RYALKDTDEE
3560 3570 3580 3590 3600
VREFLQNNLN LQGKVEGSPS LRWQMALYRG VPGREEDADD PEKIVRRVQE
3610 3620 3630 3640 3650
VSAVLYHLDQ TEHPYKSKKA VWHKLLSKQR RRAVVACFRM TPLYNLPTHR
3660 3670 3680 3690 3700
ACNMFLESYK ASWILTEDHS FEDRMIDDLS KAGEQEEEEE EVEEKKPDPL
3710 3720 3730 3740 3750
HQLVLHFSRT ALTEKSKLDE DYLYMAYADI MAKSCHLEEG GENVEEGGEE
3760 3770 3780 3790 3800
EEVEVSFEEK EMEKQRLLYQ QSRLHNRGAA EMVLQMISAC KGETGAMVSS
3810 3820 3830 3840 3850
TLKLGISILN GGNAEVQQKM LDYLKDKKEV GFFQSIQALM QTCRWPHKTL
3860 3870 3880 3890 3900
SQREGQEERV MKVQTSGTLV IINRQNGEKV MADDEFTQDL FRFLQLLCEG

HNN
Length:3,903
Mass (Da):438,608
Last modified:February 19, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00A45C0BBA9C9B29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMY4RYR1_RAT
Ryanodine receptor 1
Ryr1
5,035Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K5J1A0A0G2K5J1_RAT
Ryanodine receptor 1
Ryr1
5,012Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07002875 Genomic DNA No translation available.
AABR07002876 Genomic DNA No translation available.
AABR07071894 Genomic DNA No translation available.
AC118147 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000027893; ENSRNOP00000027893; ENSRNOG00000020557

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07002875 Genomic DNA No translation available.
AABR07002876 Genomic DNA No translation available.
AABR07071894 Genomic DNA No translation available.
AC118147 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiV9GZ83

Genome annotation databases

EnsembliENSRNOT00000027893; ENSRNOP00000027893; ENSRNOG00000020557

Organism-specific databases

RGDi1586637 Ryr1

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
GeneTreeiENSGT00940000155288

Gene expression databases

BgeeiENSRNOG00000020557 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiV9GZ83 baseline and differential

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR014821 Ins145_P3_rcpt
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR035910 RyR/IP3R_RIH_dom_sf
IPR033215 RyR1
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PANTHERiPTHR13715:SF15 PTHR13715:SF15, 1 hit
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF02815 MIR, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF49899 SSF49899, 3 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiV9GZ83_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: V9GZ83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 19, 2014
Last sequence update: February 19, 2014
Last modified: July 31, 2019
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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