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The annotation and conditions in this rule are derived from the following entries: P32875 (LIPA_YEAST), Q8IDQ0 (LIPA_PLAF7)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00206
    • taxon = Eukaryota
    • fragment ≠ the sequence is fragmented
    • Does not match HAMAP signature MF_03129
    • Matches HAMAP signature MF_00206
    • gene location = Plastid
    • fragment ≠ the sequence is fragmented
    • Does not match HAMAP signature MF_03129
    • Matches HAMAP signature MF_00206
    • gene location = Plastid
    • fragment ≠ the sequence is fragmented
    • Does not match HAMAP signature MF_03129
    • taxon ≠ Eukaryota
    • Matches HAMAP signature MF_00206
    • gene location = Plastid
    • fragment ≠ the sequence is fragmented
    • Does not match HAMAP signature MF_03128
    • taxon ≠ Eukaryota
    • Matches HAMAP signature MF_00206
    • gene location = Plastid
    • fragment ≠ the sequence is fragmented
    • taxon ≠ Eukaryota

Special conditions

    • gene location = Plastid; Organellar chromatophore
    • taxon = Apicomplexa
    • gene location ≠ Plastid; Organellar chromatophore
    • taxon ≠ Apicomplexa
    • gene location ≠ Plastid; Organellar chromatophore
    • Subsequence at position 161 - 161 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 1 (4Fe-4S)")
    • Subsequence at position 185 - 185 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 2 (4Fe-4S-S-AdoMet)")
    • Subsequence at position 181 - 181 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 2 (4Fe-4S-S-AdoMet)")
    • Subsequence at position 150 - 150 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 1 (4Fe-4S)")
    • Subsequence at position 155 - 155 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 1 (4Fe-4S)")
    • Subsequence at position 188 - 188 aligns to "C" in entry P32875 (individually applies "Iron-sulfur 2 (4Fe-4S-S-AdoMet)")
    • Predicted signal

... then these annotations are applied i

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi

  • Recommended name:
    Lipoyl synthase, organellar chromatophore (EC:2.8.1.8)
    Alternative name(s):
    Lipoate synthase
    Short name:
    Lip-syn
    Short name:
    LS
    Lipoic acid synthase
  • Recommended name:
    Lipoyl synthase, apicoplast (EC:2.8.1.8)
    Alternative name(s):
    Lipoate synthase
    Short name:
    Lip-syn
    Short name:
    LS
    Lipoic acid synthase
  • Recommended name:
    Lipoyl synthase, mitochondrial (EC:2.8.1.8)
    Alternative name(s):
    Lipoate synthase
    Short name:
    Lip-syn
    Short name:
    LS
    Lipoic acid synthase

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi

  • Name:LIAS
  • Name:lipA
  • Name:LIP5
  • Name:Las

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> describes the function(s) of a protein.<p><a href='/help/function' target='_top'>More...</a></p>Functioni

  • Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi

<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>Chaini

  • @CHAIN_NAME@i (to residues corresponding to positions @TO|+1@i - @CTER@i)

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi

  • Iron-sulfur 1 (4Fe-4S) (to residues corresponding to position 161)
  • Iron-sulfur 2 (4Fe-4S-S-AdoMet) (to residues corresponding to position 185)
  • Iron-sulfur 2 (4Fe-4S-S-AdoMet) (to residues corresponding to position 181)
  • Iron-sulfur 1 (4Fe-4S) (to residues corresponding to position 150)
  • Iron-sulfur 1 (4Fe-4S) (to residues corresponding to position 155)
  • Iron-sulfur 2 (4Fe-4S-S-AdoMet) (to residues corresponding to position 188)

<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei

  • (to residues corresponding to positions @NTER@i - @TO@i)

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO (Gene Ontology) termsi

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