"Results identified a new tumor suppressor CHL1 located at 3p26 which was frequently deleted in esophageal squamous cells carcinoma (ESCC). Reduced expression of CHL1 correlated with poor differentiation increased invasion lymph-node metastasis advanced tumor stage and decreased overall survival. Further data support CHL1 as an important tumor suppressor with both anti-proliferation and anti-metastasis abilities."xsd:string