"Results show that ablation of the three members of the retinoblastoma family (RB1 p107 and p130) which targets a variety of adult lung epithelial cells leads to spontaneous velopment of tumorlets benign precancerous neuroendocrine (NE) lesions that do not progress to malignant tumors. Data imply the requirement of other oncogenic signaling pathways for full transformation in NE lung lesions mutant for the Rb family."xsd:string