"Protein/gene_name: ARF. Function: ARF (CDKN2A) inhibits nucleolar import of TTF1 (TTF-I; Transcription Termination Factor I) by binding and inhibiting function of the TTF1 nucleolar localization sequences and causing the accumulation of TTF1 in the nucleoplasm. Nuclear TTF1 is required for transcription of the major ribosomal genes (the rDNA). NPM is a chaperone that binds TTF1 and is required for TTF1 nucleolar import/localization. Its knockdown prevents nucleolar localization of TTF1."xsd:string