"Loss of STAG2 or STAG3 which encode subunits of the cohesin complex in melanoma cells results in resistance to BRAF inhibitors (BRAFi). Loss-of-function mutations in STAG2 as well as decreased expression of STAG2 or STAG3 proteins were found in several tumor samples from patients with acquired resistance to BRAFi and in BRAFi-resistant melanoma cell lines."xsd:string