"our study demonstrate that KCTD12 binds to CDC25B and activates CDK1 and Aurora A to facilitate the G2/M transition and promote tumorigenesis and that Aurora A phosphorylates KCTD12 at serine 243 to trigger a positive feedback loop thereby potentiating the effects of KCTD12. Thus the KCTD12-CDC25B-CDK1-Aurora A axis has important implications for cancer diagnoses and prognoses."xsd:string