"Exposure of primary hippocampal neurons to Abeta42 induced an overexpression of intracellular clusterin but the level of clusterin in supernatants did not change. Moreover in APP/PSEN1 mice there was a significant increase in intracellular clusterin in cortex and hippocampus compared to age-matched wild-type (WT) mice while serum clusterin level in APP/PSEN1 mice and in WT mice has no significant difference."xsd:string