"The data of this study suggest that Dkk3 is an agonist of Wnt signaling and the ability of transgenic expression of Dkk3 to compensate for the decrease in Dkk3 expression in AD mice reverse dysfunctional Wnt signaling and partially inhibit the pathological development of AD suggests that Dkk3 could serve as a therapeutic target for the treatment of AD."xsd:string