"we showed that M at the position 61 is highly conserved in the many mammals other than orangutan and humans. In addition introduction of M61R and M61I to WT mouse AMCase lead to a significant reduction of its chitinolytic activity. Taken together our present and previous data by Seibold et al. (2009) indicate that G339T (R61M) in humans is associated with asthma protection in the fashion of gain of function"xsd:string