"The present study has successfully demonstrated that FOXC1 protein plays a crucial part in regulating VIC osteogenic differentiation. At the same time we also proved that FOXC1 is a direct target gene of miR- 138 using dual-luciferase reporter assay. Our study also confirmed the function of FOXC1 in regulating osteogenic differentiation of human aortic valvular Interstitial Cells."xsd:string