"Study combined biochemical and structural approaches to characterize the biochemical activity of human DOCK5DHR2 and its inhibition by small molecules C21 a small molecule that inhibits mouse Dock5 in cells and blocks bone degradation in mice models of osteoporosis and CPYPP which inhibits both DOCK5 and Trio. C21 uses intramolecular dynamics of DOCK5 and Rac1 to remodel the complex into an unproductive conformation."xsd:string