"Histological and molecular analysis of livers from heterozygous mice carrying the 99J mutation Tmed299J/+ revealed a requirement for TMED2 in liver health. The study shows that Tmed299J/+ mice had decreased levels of TMED2 and TMED10 dilated endoplasmic reticulum membrane and increased phosphorylation of eIF2alpha indicating endoplasmic reticulum - stress."xsd:string