"In this study we found that the wnt co-receptor Lrp6 was a potent positive regulator of beta-catenin signaling in TDI-induced asthma models both in vivo and in vitro. Additionally for the first time we demonstrated that RAGE could mediate phosphorylation of Lrp6 suggesting a functional cross talk between RAGE and the canonical wnt/beta-catenin signaling pathway involved in mediating beta-catenin activation."xsd:string