"Study shows that DUOXA1 is overexpressed in platinum-resistant ovarian cancer (OC) cells resulting in over production of reactive oxygen species (ROS). Elevated ROS level sustains the activation of ATR-Chk1 pathway leading to resistance to cisplatin in OC cells. Clinical studies also confirm the activation of ATR and DOUXA1 in OC patients and elevated DOUXA1 or ATR-Chk1 pathway correlates with poor prognosis."xsd:string