"Myofibrogenesis in cultured Npr2(+/)(-) fibroblasts was insensitive to CNP treatment. Aged Npr2(+/)(-) and Npr2(+/)(-);Ldlr-/- mice developed cardiac dysfunction and ventricular fibrosis. Aortic valve function was impaired in Npr2(+/)(-) and Npr2(+/)(-);Ldlr(-/)(-) mice with increased valve thickening myofibrogenesis osteogenesis proteoglycan synthesis collagen accumulation and calcification."xsd:string