"We demonstrated a significant upregulation of PROK2 levels in brain tissues of Abeta1-42 i.c.v. injected rats transgenic AD mice (Tg2576) and in the hippocampus of AD patients. Additionally through a pilot study an approximate twofold increase of PROK2 levels has been proved in the serum of AD patients compared to the control subjects identifying a potential blood-based biomarker of the disease."xsd:string