"The importance of the ATRX/DAXX pathway was confirmed by the first-ever pancreatic neuroendocrine neoplasms (pNEN)-specific protein-damaging hotspot mutation in DAXX. In this study both novel genes including the pro-apoptotic CYFIP2 gene and hedgehog signaling PTCH2 and novel pathways such as the MAPK-ERK pathway were implicated in pNEN."xsd:string