"generated a Dsg2 loss-of-function strain (Dsg2 (lo/lo)) and observed that in response to reduced levels of Dsg2: (i) CD31(+) endothelial cells in the pancreas are hypertrophic and exhibit altered morphology (ii) bone marrow-derived endothelial colony formation is impaired (iii) ex vivo vascular sprouting from aortic rings is reduced and (iv) vessel formation in vitro and in vivo is attenuated"xsd:string