"we propose new STLC-derived compounds that possess pronounced SIRT2 inhibition effects. These derivatives contain modified amino and carboxyl groups which conferred STLC with SIRT2 bioactivity representing an explicit repurposing approach. Compounds STC4 and STC11 exhibited half maximal inhibitory concentration values of 10.8 +/- 1.9 and 9.5 +/- 1.2 muM respectively against SIRT2"xsd:string