"We identified calmodulin-like protein 3 (CALML3) as a key sensor of this SNP and a coregulator of ERalpha which contributes to differential gene transcription regulation in an estrogen and SERM-dependent fashion. Furthermore using CRISPR/Cas9-engineered ZR75-1 breast cancer cells with different ZNF423 SNP genotypes striking differences in cellular responses to SERMs and PARP inhibitors alone or in combination"xsd:string