"Using animal models of glioblastoma and animals with deficiency in GCN2 study revealed that GCN2 deficiency limited CD8+ T-cell activation and expression of cytotoxic markers in glioblastoma. Reduction in amino acid availability caused GCN2 deficient CD8+ T-cells to become rapidly necrotic. Data demonstrate the vital importance of intact GCN2 signaling on CD8+ T-cell function and survival in glioblastoma."xsd:string