"F-box only protein 2 (FBXO2) a substrate recognition component of the Skp1-Cul1-F-box protein (SCF) E3 ubiquitin ligase complex was upregulated in livers of obese mice. Furthermore using a protein purification approach combined with high-performance liquid chromatography/tandem mass spectrometry we carried out a system-wide screening of FBXO2 substrates in which the insulin receptor (IR) was identified as a substrate"xsd:string