"Study used Tph2 +/+APP/PS1 mice and Tph2 -/-APP/PS1 mice at 6 months (6m) 8 months (8m) and 10 months (10m) to assess the roles of Tph2 in the formation of senile plaques. Reported density changes of GFAP+ astrocytes colocalization between Abeta plaques or neurons and autophagy markers LC3 P62. Results indicate that Tph2 CKO can exacerbate neuropathological characteristics of Abeta in Alzheimer's disease mice."xsd:string