"Dsg2 expression dramatically enhances the rate of spontaneous basal cell carcinoma (BCC) formation in mouse models of Gorlin syndrome. In vitro studies showed that Dsg2 potentiates canonical hedgehog (Hh) signaling and Stat3 activation in ASZ001 BCC cells in both an autocrine and paracrine manner. Data showed that Dsg2 induces a paracrine mediator that stimulates the canonical Hh signaling through Stat3."xsd:string