"Hepatocellular carcinoma (HCC) tumors with low expression of PRDX4 had higher ROS levels malignancy and associated with reduced overall survival. In HCC cell lines its knockdown led to increased intracellular ROS level and suppressed cell proliferation inducing cell death. These results indicate that PRDX4 has an inhibitory effect in the initiation of HCC but a dual (inhibitory or promoting) role in the progression."xsd:string